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Theobromine in Dark Chocolate may Slow Biological Aging

A chemical found in dark chocolate could slow the rate of biological aging.

11 Dec 2025

Decoding the Interaction Between SV2A Protein and Anti-Epileptic Drugs

A multi-institute team led by St. Jude Children's Research Hospital and UT Southwestern Medical Center investigators established for the first time how certain drugs used to treat epilepsy affect their target.

2 Dec 2025

New Regulatory Pathway Enhances Key Aroma Compound in Wine Grapes

β-Damascenone is a key norisoprenoid compound responsible for characteristic floral and fruity aromas in grapes and wines, particularly those from non-aromatic varieties such as Cabernet Sauvignon and Merlot.

27 Nov 2025

UBQLN2 Liquid Droplets Found to Catalyze Early α-Synuclein Aggregation

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region of the brain, damaging these neurons and leading to the motor symptoms of the disease. α-synuclein (α-syn), a misfolded protein, aggregates and forms fibrils, which leads to the formation of LBs.

27 Nov 2025

Senescent Blood Vessel Cells Drive the Development of Metabolic Disorders

Investigators from the Center for Advanced Gerotherapeutics at Cedars-Sinai found that aged blood vessel cells play a key role in the development of metabolic disorders, including diabetes.

24 Nov 2025

Innovative Sensor Enables Live Observation of DNA Repair in Living Cells

Cancer research, drug safety testing and ageing biology may all gain a major boost from a new fluorescent sensor developed at Utrecht University.

22 Nov 2025

Transcription Factor SmMYB53 Drives Enhanced Tanshinone Synthesis in Salvia miltiorrhiza

Salvia miltiorrhiza has long been used in traditional medicine, with tanshinones being its main active compounds.

19 Nov 2025

Cellarity's AI Model Predicts Drug Induced Liver Injury

Cellarity, a clinical-stage biotechnology company developing Cell State-Correcting therapies through integrated multi-omics and AI modeling, today announced the publication of a seminal manuscript in Nature Communications, which describes a novel framework for the prediction and characterization of drug-induced liver injury (DILI), along with open-source posting of the model and validation data.

14 Nov 2025

‘Forever chemicals’ build up in British Columbia sea otters

PFAS contamination in British Columbia sea otters underscores urban pollution's effects on marine life and the importance of long-term ecological monitoring.

12 Nov 2025

St. Jude Scientists Discover Hidden Binding Pocket in Nuclear Receptors

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.

7 Nov 2025

Intracellular Compounds Offer Blueprint for Next-Generation Targeted Therapies

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest receptors into precision tools - opening the door to a new generation of safer, smarter medicines.

3 Nov 2025

Breakthrough Small Molecule Offers New Hope for Diabetes Treatment

Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.

31 Oct 2025

Flower-scented Fungus That Kills Mosquitoes Naturally

In the war against mosquito-borne illnesses that claim the lives of hundreds of thousands annually, researchers have sought an unexpected partner: a fungus that emits a floral scent.

27 Oct 2025

The Biological Tagging of Astrocytes Enhances Memory Recall

Why are we able to recall only some of our past experiences? A new study led by Jun Nagai at the RIKEN Center for Brain Science in Japan has an answer.

16 Oct 2025

Framework Evaluating Economic and Environmental Sustainability of Medical Drugs

The production of medical drugs is costly and may negatively impact the environment. Researchers Stefano Cucurachi and Justin Lian have created a framework designed to assist the healthcare system in evaluating the economic and environmental sustainability of medical compounds.

16 Oct 2025

Optimized Culture Conditions Reveal Hidden Antimicrobial Molecules in Dictyostelium

The cellular slime mold Dictyostelium discoideum is a soil microbe that produces diverse natural products with potential antibiotic activity.

10 Oct 2025

Understanding the Impact of Phytohormones on Plant Adaptation in Extreme Environments

Which plant hormones are critical in responding to drought conditions? How do plant hormone responses adjust to environmental changes?

3 Oct 2025

Unique Cytochrome Protein Holds Key to Plant Survival and Metabolism

Despite their fundamental differences, plants, animals, and fungi share certain metabolic processes.

17 Sep 2025

Microbial Molecule Controls Cancer Progression and Boosts Chemotherapy

An international team of scientists led by researchers from the MRC Laboratory of Medical Sciences (LMS), Imperial College London, and the University of Cologne discovered that microbes associated with tumors produce a molecule that can control cancer progression and improve chemotherapy efficacy.

15 Sep 2025

Understanding How Bacteria Exploit Plant Growth Hormones to Attack Crops

Aphids, grasshoppers and other bugs aren't the only pests that can quickly wipe out a crop. Many harmful bacteria have evolved ways to bypass a plant's defenses.

11 Sep 2025