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New AI Tool Guides Chemists Toward Faster Drug Discovery

Drug discovery is like molecular Tetris. Chemists snap atoms together, adjusting the pieces until everything fits and suddenly, a molecule makes a promising new medicine.

10 Mar 2026

Mars Soil May Harm Living Organisms

Tardigrades, also known as water bears, could be better recognized by a new name: Tardiguardians of the Galaxy.

2 Mar 2026

Promega Unveils Cellular Target Engagement Technology Aimed at Expanding the Druggable Proteome at SLAS 2026

Promega Corporation is launching a new live-cell target engagement platform that could close a long-standing gap between biochemical and cellular assays for understudied or difficult-to-interrogate proteins.

27 Feb 2026

5,000-Year-Old Cave Bacterium Resists Antibiotics and Kills Pathogens

Psychrobacter SC65A.3, preserved in cave ice, harbors multidrug resistance genes and exhibits antimicrobial activity, offering insights into ancient resistomes.

26 Feb 2026

Engineered E. coli Produces Key Plant Compound at Record Levels

Researchers engineered E. coli to produce orsellinic acid-derived meroterpenoids, offering a sustainable alternative to traditional plant extraction methods.

25 Feb 2026

Scientists Create Charge-Free Polymer to Improve Gene Therapy Delivery

Researchers from Tokyo Metropolitan University have created a new molecule which carries DNA into biological cells, to treat or vaccinate against illnesses.

23 Feb 2026

Microbial Engineering Breakthrough Improves Supply of Promising Pharmaceuticals

Bioengineered E. coli bacteria can now produce a group of compounds with anticancer, anti-HIV, antidiabetic and anti-inflammatory activities.

18 Feb 2026

Chemical Tweaks Boost Peptide Stability and Antimicrobial Power

Antibiotic treatments are losing effectiveness against a range of common bacterial pathogens, including E. coli, K. pneumoniae, Salmonella and Acinetobacter, according to a warning issued by the World Health Organization last October.

16 Feb 2026

Mapping the Binding Energy of Histamine Receptors

G-protein-coupled receptors (GPCRs) are one of the biggest groups of cell surface proteins in the human body, recognizing hormones, neurotransmitters, and drugs.

16 Feb 2026

New Boron Compounds Enable Easier Drug Modification Without Breakdown

A major step towards simpler drug development has been taken at the University of Gothenburg. In a new study, researchers have developed stable boron-fluorine compounds that make it possible to increase the effect or reduce side effects without breaking down the medicine.

4 Feb 2026

Gut Microbial Metabolite Hippuric Acid Amplifies Immune Responses

Scientists at The Wistar Institute have identified a previously overlooked mediator in the body's response to life-threatening infections: hippuric acid, a metabolite produced when gut bacteria break down polyphenols from berries, tea, and other plant-based foods.

31 Jan 2026

Trojan Horse Drug Works in Combination With Copper to Kill Bacteria

A research team at the University of Arizona College of Medicine – Tucson is developing a drug that works in combination with copper to kill bacteria, including those that cause MRSA, a type of staph infection that is resistant to usual treatments.

24 Jan 2026

Coordinated Gene Regulation Drives Saponin Production

Triterpenoid saponins are widely valued for their diverse pharmacological activities and also play important defensive roles in plants.

22 Jan 2026

New Molecules Harness Cellular Recycling to Eliminate Cancer's Immune Shield IDO1

Cells have a remarkable housekeeping system: proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in the cellular recycling machinery.

8 Jan 2026

Blocking Retinoic Acid Pathway Improves Dendritic Cell Anti-Tumor Function

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response and, in a different context, the efficacy of a promising type of cancer vaccine.

6 Jan 2026

Theobromine in Dark Chocolate may Slow Biological Aging

A chemical found in dark chocolate could slow the rate of biological aging.

11 Dec 2025

Decoding the Interaction Between SV2A Protein and Anti-Epileptic Drugs

A multi-institute team led by St. Jude Children's Research Hospital and UT Southwestern Medical Center investigators established for the first time how certain drugs used to treat epilepsy affect their target.

2 Dec 2025

New Regulatory Pathway Enhances Key Aroma Compound in Wine Grapes

β-Damascenone is a key norisoprenoid compound responsible for characteristic floral and fruity aromas in grapes and wines, particularly those from non-aromatic varieties such as Cabernet Sauvignon and Merlot.

27 Nov 2025

UBQLN2 Liquid Droplets Found to Catalyze Early α-Synuclein Aggregation

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region of the brain, damaging these neurons and leading to the motor symptoms of the disease. α-synuclein (α-syn), a misfolded protein, aggregates and forms fibrils, which leads to the formation of LBs.

27 Nov 2025

Senescent Blood Vessel Cells Drive the Development of Metabolic Disorders

Investigators from the Center for Advanced Gerotherapeutics at Cedars-Sinai found that aged blood vessel cells play a key role in the development of metabolic disorders, including diabetes.

24 Nov 2025