Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Study Identifies Protein Involved as Key Structural Anchor for Bacterial Membranes

Researchers at the University of Notre Dame and collaborators have discovered a key process for how the outer membrane of gram-negative bacteria attaches to the cell wall, advancing the understanding of how these bacteria frequently manifest resistance to antibiotics.

16 Jun 2026

Collaborative Research Discovers New Treatments for Alzheimer' Disease

A new multimillion-dollar project will bring together researchers from the Indiana University School of Medicine and the IU Luddy School of Informatics, Computing, and Engineering as they work to solve one of medical science's greatest needs: Identifying new treatments for Alzheimer's disease and related dementias.

16 Jun 2026

Streamlining Complex Drug Development by Directly Editing Core Molecular Frameworks

For more than a hundred years, chemists have been building complex molecules step by step – bond by bond, atom by atom.

16 Jun 2026

Laser Phase Plate in the Electron Microscope Promises Clear Images of Tiniest Proteins

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase-contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside cells that had previously been too faint or washed out for biologists to study.

12 Jun 2026

Building More Realistic Human Tissue Models With Assembloids

Assembloids combine organoids and specialized cells, creating advanced models for drug testing and regenerative medicine with improved physiological relevance.

11 Jun 2026

DNA Barcode Technology Enables Massive Simultaneous Drug Candidate Validation

A Korean research team has launched a public drug discovery service capable of screening and validating tens of millions of compounds simultaneously.

10 Jun 2026

New Antibiotic Compound Blocks Ribosome to Starve Dangerous Pathogens

Researchers at McMaster University have discovered a new antibiotic that kills some of the world's most dangerous and drug-resistant bacteria - and does so by targeting a previously unknown vulnerability, opening the door to an entirely new class of treatments.

5 Jun 2026

Webinar - Modality Agnostic Drug Discovery Strategies for Data Sparse Targets: Lessons Learned From Avammune & Cresset, Hosted by Visioneers

Are you working on data-sparse or novel targets? Join us June 11th to learn how Avammune progressed from early concepts to trial-stage candidates in this space.

From Cresset 4 Jun 2026

Introducing Evosep Proteomics to Standardize and Scale Proteomics for Research and Drug Development

Evosep announces the launch of Evosep Proteomics, an ecosystem designed to standardize and scale LC-MS-based proteomics for research and pharmaceutical drug development.

From Evosep 2 Jun 2026

Novel Cyclic Peptides Cross Cell Membranes to Fight Disease

Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is difficult because our typic "small-molecule" drugs often prove to be too small to grip the broad, flat surfaces involved in protein-protein interactions.

1 Jun 2026

Synthetic Biology and Artificial Intelligence Transform the Discovery of Mysterious Orphan Receptors

A new review highlights how synthetic biology, AI, and spatial omics could transform ligand-receptor discovery from one-by-one searches into network-level mapping

23 May 2026

AI Designs Custom Miniproteins to Precisely Control Cell Receptors

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our bodies - from the ability to see and smell, to sensing of adrenaline, insulin, nutrients and medicines.

22 May 2026

Drug-Resistant Superbugs Contribute to Nearly Five Million Global Human Deaths Every Year

A team of researchers from Florida State University and the National High Magnetic Field Laboratory is looking to nature to find microbes that can be used to create new antibiotics to treat the growing threat of drug-resistant bacteria.

22 May 2026

Novel Formicitoxins Found in Carpenter Ant Venom Offer Drug Discovery Impetus

The venom of forest ants and horse ants contains numerous substances that protect the insects from pathogens. Researchers at Martin Luther University Halle-Wittenberg (MLU) and Freie Universität Berlin have succeeded for the first time in identifying and characterizing these novel antimicrobial substances in the insects' venom.

19 May 2026

Novel RNA Analysis Method Supports Antiviral Drug Discovery

Researchers from A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new method, called 'sm-PORE-cupine', to study individual RNA molecules and reveal how their structures influence gene regulation, a fundamental process that affects how cells function in health and disease.

15 May 2026

Advanced Molecular Blueprints Guide Development Of Next-Generation Malaria Drugs

Researchers from the Universities of Bath and Leeds (UK) have made a significant advance in the fight against malaria by uncovering a promising new potential target for drug discovery.

7 May 2026

CapyBio Launches New Analysis Services to Improve Cell Identity Engineering

CapyBio, a cell identity tools and services company, today announced the launch of three new commercial analysis services: Capybara™ Benchmarking Analysis, Capybara Advanced Analysis, and CellOracle™ Differentiation Optimization Analysis.

7 May 2026

AI Designs New Antibiotics That Reduce MRSA Infections In Mice

SyntheMol-RL integrates reinforcement learning for antibiotic design, producing synthesizable candidates that show efficacy against MRSA in preclinical models.

5 May 2026

Proxygen Expands Platform Beyond Degradation to Build Next-Generation Induced Proximity Therapeutics

Proxygen, a biotechnology company pioneering the discovery of molecular glue degraders and next-generation proximity-based therapeutics, today publicly announced the expansion of its platform beyond targeted protein degradation to access a broader range of induced proximity therapeutics, while advancing two lead molecular glue degrader programs toward clinical development.

From Proxygen 29 Apr 2026

Generative AI Model Accelerates Drug Discovery With New Antibiotic Candidate

Researchers at McMaster University have developed a new generative artificial intelligence (AI) model capable of drastically speeding up drug discovery - and, in early tests, it has already designed a brand-new antibiotic.

24 Apr 2026

Drug Discovery News and Research

Further Reading

Study Identifies Protein Involved as Key Structural Anchor for Bacterial Membranes

Collaborative Research Discovers New Treatments for Alzheimer' Disease

Streamlining Complex Drug Development by Directly Editing Core Molecular Frameworks

Laser Phase Plate in the Electron Microscope Promises Clear Images of Tiniest Proteins

Building More Realistic Human Tissue Models With Assembloids

DNA Barcode Technology Enables Massive Simultaneous Drug Candidate Validation

New Antibiotic Compound Blocks Ribosome to Starve Dangerous Pathogens

Webinar - Modality Agnostic Drug Discovery Strategies for Data Sparse Targets: Lessons Learned From Avammune & Cresset, Hosted by Visioneers

Introducing Evosep Proteomics to Standardize and Scale Proteomics for Research and Drug Development

Novel Cyclic Peptides Cross Cell Membranes to Fight Disease

Synthetic Biology and Artificial Intelligence Transform the Discovery of Mysterious Orphan Receptors

AI Designs Custom Miniproteins to Precisely Control Cell Receptors

Drug-Resistant Superbugs Contribute to Nearly Five Million Global Human Deaths Every Year

Novel Formicitoxins Found in Carpenter Ant Venom Offer Drug Discovery Impetus

Novel RNA Analysis Method Supports Antiviral Drug Discovery

Advanced Molecular Blueprints Guide Development Of Next-Generation Malaria Drugs

CapyBio Launches New Analysis Services to Improve Cell Identity Engineering

AI Designs New Antibiotics That Reduce MRSA Infections In Mice

Proxygen Expands Platform Beyond Degradation to Build Next-Generation Induced Proximity Therapeutics

Generative AI Model Accelerates Drug Discovery With New Antibiotic Candidate

eBook: Essential Guide to Organoids for Drug Discovery Applications eBook

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

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