Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Advanced Molecular Blueprints Guide Development Of Next-Generation Malaria Drugs

Researchers from the Universities of Bath and Leeds (UK) have made a significant advance in the fight against malaria by uncovering a promising new potential target for drug discovery.

7 May 2026

CapyBio Launches New Analysis Services to Improve Cell Identity Engineering

CapyBio, a cell identity tools and services company, today announced the launch of three new commercial analysis services: Capybara™ Benchmarking Analysis, Capybara Advanced Analysis, and CellOracle™ Differentiation Optimization Analysis.

7 May 2026

AI Designs New Antibiotics That Reduce MRSA Infections In Mice

SyntheMol-RL integrates reinforcement learning for antibiotic design, producing synthesizable candidates that show efficacy against MRSA in preclinical models.

5 May 2026

Proxygen Expands Platform Beyond Degradation to Build Next-Generation Induced Proximity Therapeutics

Proxygen, a biotechnology company pioneering the discovery of molecular glue degraders and next-generation proximity-based therapeutics, today publicly announced the expansion of its platform beyond targeted protein degradation to access a broader range of induced proximity therapeutics, while advancing two lead molecular glue degrader programs toward clinical development.

From Proxygen 29 Apr 2026

Generative AI Model Accelerates Drug Discovery With New Antibiotic Candidate

Researchers at McMaster University have developed a new generative artificial intelligence (AI) model capable of drastically speeding up drug discovery - and, in early tests, it has already designed a brand-new antibiotic.

24 Apr 2026

Fragment-Based Drug Design Accelerates Efficient Discovery of New Medicines

Modern medicine has played a significant role in improving the length and quality of our lives. While many treatments may seem like miracles, they are the result of a lengthy, rigorous research process.

24 Apr 2026

Protein Shape Changes Come Into Focus With LiP-MS and 3D Proteomics

This review explains how LiP-MS detects protein structural changes across whole proteomes, adding functional insight that standard abundance-based proteomics often misses. It also surveys method variants and shows how LiP-MS supports drug-target discovery, disease biomarker research, and the broader framework of “3D proteomics.”

20 Apr 2026

Cutting-Edge AI Tool Could Accelerate the Creation of New Medicines

University of Virginia School of Medicine scientists have developed a bold new approach to drug development and discovery that could dramatically accelerate the creation of new medicines.

10 Apr 2026

Study Reveals Pol Theta Role in Cancer DNA Repair

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized.

8 Apr 2026

Novel ENDOtollins Block Harmful Inflammation While Preserving Infection Response

Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact-a long-sought goal in treating autoimmune diseases.

7 Apr 2026

PRISM ALS: New Stem Cell Models Could Transform Research into Treatments for MND/ALS

A new global initiative launched today aims to close a critical gap in ALS/MND drug discovery – current cell models used for testing treatments do not currently reflect the diverse nature of the disease – that affects both researchers developing therapies and the people urgently waiting for them.

From Axol Bioscience Ltd 2 Apr 2026

New Technology Enables Whole-Body Analysis of Gene Expression

Understanding gene expression within the body has been a boon for 21st century biology and therapeutics, but most discoveries that use these technologies only focus on one organ or one small area of tissue.

30 Mar 2026

Computational Chemistry Maps Spliceosome Dynamics at Atomic Resolution

A new study from the Italian Institute of Technology (IIT), in collaboration with Uppsala University (Sweden) and AstraZeneca, shows how computational chemistry and supercomputers can help scientists better understand the fundamental mechanisms of life, specifically those of human cells.

28 Mar 2026

New AI Tool Guides Chemists Toward Faster Drug Discovery

Drug discovery is like molecular Tetris. Chemists snap atoms together, adjusting the pieces until everything fits and suddenly, a molecule makes a promising new medicine.

10 Mar 2026

Bacteria-Powered Drug Discovery: A Greener Path to Curing "Undruggable" Cancers

Researchers at the University of Bath have developed a new technology that uses bacteria to build, chemically stabilize, and test millions of potential drug molecules inside living cells, making it much quicker and easier to discover new treatments for difficult-to-treat cancers.

4 Mar 2026

Promega Unveils Cellular Target Engagement Technology Aimed at Expanding the Druggable Proteome at SLAS 2026

Promega Corporation is launching a new live-cell target engagement platform that could close a long-standing gap between biochemical and cellular assays for understudied or difficult-to-interrogate proteins.

27 Feb 2026

Structural Blueprint of Cellular Biomolecular Condensates Opens New Therapeutic Possibilities

Cells rely on biomolecular condensates to coordinate essential biological processes without surrounding membranes.

26 Feb 2026

Engineered E. coli Produces Key Plant Compound at Record Levels

Researchers engineered E. coli to produce orsellinic acid-derived meroterpenoids, offering a sustainable alternative to traditional plant extraction methods.

25 Feb 2026

SeekGene Joins Human Cell Atlas Consortium to Advance Multiomics Research

SeekGene, a biotechnology company focused on "driving the development and democratization of innovative single-cell technologies", announced it has officially joined the Human Cell Atlas (HCA) Commercial Discount Program, providing eligible consortium members with exclusive commercial discounts on its single-cell platforms and assays to support large-scale cell atlas research worldwide.

12 Feb 2026

Machine Learning Model Accelerates Manufacturing Timeline of Monoclonal Antibodies

As instigators of immunity, monoclonal antibodies are marvels of modern medicine, lab-made proteins that can treat cancers, autoimmune diseases, and many other conditions.

10 Feb 2026