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Latent HIV Viral Proteins Drive Persistent Low-Grade Brain Inflammation During ART

Antiretroviral drugs let people with HIV live full-length lives, but cognitive problems often persist. Some studies have found cognitive impairment in as many as half of people receiving antiretroviral therapy, although estimates vary and many cases do not interfere with daily activities.

24 Sep 2026

Infected Macrophages Release Inflammatory Signals That Accelerate Surrounding Lung Infection

In the sickest COVID-19 patients, the SARS-CoV-2 virus doesn't just cause severe damage by directly infecting airway cells.

22 Sep 2026

Researchers Discover Dual Immune Mechanisms Controlling Latent HIV Vectors

There is no cure for HIV. While scientists have made considerable progress in controlling the infection, patients still must take daily antiretroviral medication for the rest of their lives.

18 Sep 2026

Multiple Specialized Immune Cells Cooperate to Suppress Opportunistic Lung Fungi

Most people carry the fungus Cryptococcus neoformans in their lungs for life and never know it, held in check by the immune system.

21 Aug 2026

Study Reveals Why People Are At Greater Risk of Fungal Infections Than Others

A study on Candida albicans uncovers immune mechanisms that prevent systemic infections, emphasizing the role of IL-1 cytokines and neutrophil response.

13 Aug 2026

Newly Identified Protein Prevents T Cells From Destroying Cancer Cells

Researchers at Mayo Clinic have identified a protein that cancer cells use to suppress the body's immune response, a finding that could support the development of new treatments to improve the effectiveness of cancer immunotherapies.

5 Aug 2026

Deep Mutational Scanning Unlocks Hidden Blueprint of Antibody Selection Processes

A new study tracking thousands of B cells across more than 100 germinal centers in mice reveals how the system consistently produces highly effective antibodies.

8 Jun 2026

Study Explains Why Persistent Gut Damage Continues Despite HIV Treatments

For many people living with HIV, today's treatments can suppress the virus and dramatically improve health. But even when HIV is controlled, damage to the gut caused by the disease can persist, fueling chronic inflammation linked to serious health problems. A new Tulane University study published in JCI Insight helps explains why.

23 May 2026

DNA-Guided CRISPR Technology Enhances Precision and Reduces Off-Target Effects

A team of engineers at the University of Florida has developed a new form of CRISPR technology that could make diagnostics and treatments safer, more precise and more affordable, while opening the door to entirely new ways of controlling disease.

15 May 2026

HIV Mutations Undermine Broadly Neutralizing Antibody Treatments Across Strains

Broadly neutralizing antibodies (bNAbs) are among the most promising new treatments for HIV, offering the potential to forego traditional daily dose of antiretroviral drugs.

12 May 2026

New CRISPR System Destroys Diseased Cells With High Precision

A new kind of CRISPR that destroys cells rather than gene editing them has shown potential for killing sick cells while leaving healthy cells untouched.

8 May 2026

New Discovery Reveals How HIV Infects Resting Immune Cells

Researchers from Queen Mary University of London have uncovered a previously unknown mechanism by which HIV-1 can infect resting immune cells.

7 May 2026

Scientists Map Human Genes That Control HIV Infection Dynamics

The human immunodeficiency virus (HIV), which is the cause of AIDS, is a master of deception, using just nine genes to hijack the complex cellular machinery of the human body.

21 Apr 2026

Gene Editing Reprograms Immune System to Produce Therapeutic Proteins

An innovative gene-editing strategy could establish a new way for the body to manufacture therapeutic proteins-including certain kinds of highly potent antibodies the are naturally difficult to produce-by reprogramming the immune system itself.

20 Apr 2026

Nanodisc Platform Shows How Antibodies Really Target Viruses

Viruses are masters at entering human cells, thanks to specialized proteins that coat their surfaces.

13 Apr 2026

Nonviral Nanoparticles Show Promise for Safer Gene Delivery Methods

In a demonstration that helps pave the way for gene therapies with fewer side effects, several human cell types were genetically modified with protein nanoparticles designed at University of Michigan Engineering and Michigan Medicine.

1 Apr 2026

Study Explains How LACTIN-V Reduces Recurrent Bacterial Vaginosis

A new study from the Kwon Lab at the Ragon Institute, published in Cell Host & Microbe, provides the most detailed picture yet of how a promising bacterial therapy works to prevent recurrent bacterial vaginosis (BV) and why it works better for some women than others.

30 Mar 2026