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New Platform Technology Promises to Generate Hard-to-Get Human Cells

This study presents a fast method for generating human microglia from iPSCs, paving the way for breakthroughs in neurodegenerative disease research.

11 Jun 2025

Study Reveals Key Proteins Behind CAR-T Cell Therapy Effectiveness

A study conducted by researchers at the Center for Cell-Based Therapy (CTC) highlights key proteins and signaling pathways involved in the efficacy of immunotherapy based on CAR-T cells (lymphocytes modified in the laboratory to fight cancer).

4 Jun 2025

New Diagnostic Tool Enhances Early Detection of Viruses with Powerful Bioluminescence

Mass General Brigham researchers are shining a powerful new light into the viral darkness with the development of Luminescence CAscade-based Sensor (LUCAS), a rapid, portable, highly-sensitive diagnostic tool for processing complex biological samples.

2 Jun 2025

Common Genetic Variation Doubles Dementia Risk in Men, Study Finds

Research reveals men with a genetic variant may face double the dementia risk compared to women, highlighting the need for targeted prevention strategies.

2 Jun 2025

Loss of SOX9 Gene Linked to Aggressive Colorectal Cancer

Colorectal cancer is the second leading cause of cancer-related death globally. Although some of the molecular changes associated with colorectal cancer are known, how they contribute to cancer development is not yet well defined.

15 May 2025

Scientists Use AI to Predict Future Viruses and Design Better Vaccines

Effective vaccines dramatically changed the course of the COVID-19 pandemic, preventing illness, reducing disease severity, and saving millions of lives.

10 May 2025

Study Reveals T Cell Plasticity as a Key Driver of Systemic Autoimmunity

After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of "good" microbes in the gut is linked to rheumatoid arthritis and, potentially, other autoimmune diseases.

5 May 2025

Unraveling the Role of Long Noncoding RNAs in the Tumor Microenvironment

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting to influence tumorigenesis, progression, and metastasis.

25 Apr 2025

Researchers Develop STITCHR to Insert Whole Genes Without Unwanted Mutations

Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations.

12 Apr 2025

Small Hatching Embryo may Improve the Chances of IVF Success

A new research paper was published in Aging (Aging-US) Volume 17, Issue 3, on March 5, 2025, titled "Reproductive aging, preimplantation genetic testing for aneuploidy, and the diameter of blastocysts: does size matter?"

10 Apr 2025

New Insights into How B Cells Strategically Clone High-Affinity Antibodies

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies.

20 Mar 2025

Cellular Changes as Lung Damage Worsens During COVID-19 Revealed

Changes in the cellular response during lung damage caused by SARS-CoV-2 – the virus behind COVID-19 – have been uncovered.

10 Mar 2025

Colossal Creates the Colossal Woolly Mouse, Showcasing Breakthroughs in Multiplex Genome Editing and Trait Engineering on the Path to a Mammoth

In an extraordinary achievement of advanced multiplexed genome engineering, Colossal Biosciences announces the birth of the Colossal Woolly Mouse—mice engineered to express multiple key mammoth-like traits that provide adaptations to life in cold climates.

5 Mar 2025

Study Reveals How the Brain Gauges Risk and Reward in Decision-Making

Every day, our brain makes thousands of decisions, big and small. Any of these decisions - from the least consequential such as picking a restaurant to the more important such as pursuing a different career or moving to a new city - may result in better or worse outcomes.

20 Feb 2025