Neurological Disease News and Research

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Feline Dementia May Explain Synapse Loss in Alzheimers

The study uncovers amyloid-beta's role in glial-mediated synapse loss in feline cognitive dysfunction, enhancing understanding of Alzheimer's disease.

20 Aug 2025

Case Western Researchers Use Stem Cells to “Shut Off” Nerve Cell Strain

Amyotrophic lateral sclerosis (ALS), sometimes known as Lou Gehrig’s disease, is an incurable neurological disease that affects motor neurons, which are nerve cells in the brain and spinal cord that regulate voluntary muscle movement and breathing.

6 Aug 2025

Prime Editing Reverses Symptoms of Severe Childhood Neurological Disease

Scientists use a precise form of gene editing called prime editing to correct the most common genetic mutations that cause alternating hemiplegia of childhood, a rare and severe neurological disorder that begins in infancy.

From The Jackson Labs 6 Aug 2025

Microglia Replacement Halts Progression of Fatal Neurological Disease in Mice and Humans

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive neurological disease with an average age of onset of 43 years and an average life expectancy of only 3 to 5 years after symptoms begin.

11 Jul 2025

UChicago Team Receives Grant to Study RNA Splicing and Cell Stress

During the first step of converting genetic information into functional proteins, cells transcribe the double-stranded helix of DNA into single strands of RNA.

3 Jul 2025

Combination of Viral Antibodies and Genetic Risk Factors Linked to Increased MS Risk

In multiple sclerosis (MS), antibodies to the common Epstein-Barr virus can accidentally attack a protein in the brain and spinal cord. New research shows that the combination of certain viral antibodies and genetic risk factors can be linked to a greatly increased risk of MS.

12 Mar 2025

Researchers Discover New Role of Mitofusin 2 in Cellular Health

Researchers from Cologne, Bochum, Padova and Angers have discovered a novel connection between mitochondrial function, protein quality control and cellular health, whose failure could be the leading cause in the currently incurable neurological disease Charcot-Marie-Tooth (CMT).

17 Feb 2025

First Cell Atlas of Focal Cortical Dysplasia Offers New Insights for Treatment

Using a single-cell sequencing technique, Brazilian researchers have created the first cell atlas of focal cortical dysplasia (FCD), a malformation of the cerebral cortex that leads to drug-resistant epilepsy.

31 Jan 2025

Lice as Models for Studying Mitochondrial Disorders

A set of genes that in humans would suggest a late-stage degenerative disease like Parkinson’s or Alzheimer’s disease are present in lice throughout their lives.

10 Dec 2024

Study Links Archaic Gene Variant to Health Risks in First Nations Oceanians

An ancient gene mutation among First Nations inhabitants of Oceania may make them more susceptible to infectious diseases like influenza, according to a new study by scientists at the University of Colorado Anschutz Medical Campus.

30 Oct 2024

Innovative Stem Cell Research Unveils Glial Cell Dynamics in Multiple Sclerosis

Researchers from The New York Stem Cell Foundation (NYSCF) Research Institute and Case Western Reserve University have discovered novel ways in which glia, by using the largest known collection of stem cell models from MS patients, essential brain support cells contribute to the disease.

27 Aug 2024

Understanding How the Human Forebrain Develops at the Cellular Level

A group of researchers at University of California San Diego School of Medicine led an investigation that offers new insight into the development of the human forebrain.

17 Apr 2024

Traffic Jam in the Brain: Study Uncovers Cellular Cause of Rare Neurological Disease

Researchers from McGill University, led by Professor Alanna Watt of the Department of Biology, have identified previously unknown changes in brain cells affected by a neurological disease.

22 Jan 2024

The Pathogenic Mechanism Underpinning MEPAN Syndrome

New research published in Nature Metabolism discovered the pathogenic mechanism driving mitochondrial enoyl reductase protein-associated neurodegeneration (MEPAN) syndrome, a rare pediatric neurodegenerative disease.

1 Sep 2023

Viral Proteins Promote the Spread of Protein Aggregates in the Brain

Viral genetic remnants found naturally in the human genome may influence the development of neurodegenerative diseases.

22 Aug 2023

Study Uncovers Somatic Mutations That Play a Role in Common Form of Adult Epilepsy

Epilepsy affects approximately 1-in-26 people and the most common form, known as temporal lobe epilepsy (TLE), often cannot be adequately treated with anti-seizure medications.

2 May 2023

Researchers Explain How a Single Mutation Causes Ataxia

Worldwide, only a handful of patients are known to suffer from episodic ataxia type 6, a neurological disease that causes transient loss of muscle control.

4 Apr 2023

Astrocytes in the Brain may Play a Key Role in Regulating Information

Long thought of as "brain glue," the star-shaped cells called astrocytes-;members of a family of cells found in the central nervous system called glial that help regulate blood flow, synaptic activity, keep neurons healthy, and play an important role in breathing.

3 Apr 2023

WashU researcher receives NIH grant to study a poorly understood protein linked to ALS

The relentless neurological disease amyotrophic lateral sclerosis (ALS) eventually shuts down the entire body, but the devastation starts at a molecular level.

14 Feb 2023

Rare disease involving speech and motor coordination difficulties identified

Scientists from the National Institutes of Health recently identified a new neurological condition characterized by issues with motor coordination and speech. Their observations were published in the journal npj Genomic Medicine.

From National Human Genome Research Institute (NHGRI) 13 Feb 2023