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GC-MS for Biomarker Discovery

GC-MS is a powerful technique for the discovery of biomarkers. Recent studies have demonstrated success for nephrotic syndromes and metabolic diseases.

14 Feb 2020

Applications of 3D X-ray Microscopy

3D X-ray imaging allows analysis of brittle or complex biological materials without damaging them.

14 Feb 2020

How Much CBD and THC Enters the Bloodstream?

Scientists have developed an assay to measure the concentration of cannabinoids in human blood plasma during the use of cannabinoid-containing products.

14 Feb 2020

Two-photon Microscopy Principles and Methodology

Two-photon microscopy provides several advantages to confocal or fluorescence microscopy for imaging thick samples and removing out-of-focus light.

14 Feb 2020

Rabbit Monoclonal Antibodies (RabMab) Benefits

Rabbit monoclonal antibodies refer to antibodies that have been developed in rabbits rather than mice, which are most commonly used to generate antibodies.

14 Feb 2020

Cell Line Authentication using DNA Barcoding

DNA barcoding - the identification of a specific cell line using a genetic sequence - is a solution that has been proposed to solve the issue of cell line contamination.

14 Feb 2020

Photobleaching in Fluorescence Microscopy

Photobleaching is the phenomenon when a fluorophore loses its fluorescence due to damage induced by light.

14 Feb 2020

Importance of Lipidomics in Stem Cell Research

Recent studies have shown that lipids can affect the differentiation of stem cells, including the fate of mesenchymal stem cells.

14 Feb 2020

What are Polarized Light Microscopes and How Do They Work?

Polarized light microscopy enhances image contrast and improves image quality in comparison to other microscopy methods, such as fluorescence microscopy.

14 Feb 2020

Exploring the Structure-Activity Relationship (SAR) of Drugs

The structure-activity relationship (SAR) aids in understanding various aspects of drug discovery, from screening candidates to optimizing their properties.

14 Feb 2020

Counterfeiting drugs is a major problem in both developed and developing countries. It is prevalent in countries where drug regulation and enforcement are weak. Counterfeit drugs include drugs which either do not have any active ingredients, or have different active ingredients, or active ingredients with different strength compared to authentic drugs.

14 Feb 2020

How are the Metabolome and Proteome Related?

As the proteome consists of proteins and metabolome consists of an eclectic mix of molecules, ranging from amino acids to carbohydrates, it is easy to forget that these two groups are intimately connected.

14 Feb 2020

A Guide to Understanding Gene Expression

Being able to analyze gene expression patterns is essential for understanding protein function, biological pathways, and cellular responses to stimuli.

14 Feb 2020

Importance of Solubility and Lipophilicity in Drug Development

Solubility and lipophilicity are key parameters that can dictate the success or failure rate of drug discovery and development.

14 Feb 2020

Applications of Polarized Light Microscopy

In polarized light microscopy, plane-polarized light is passed through a double refracting material and then collected using a second polarizing filter.

14 Feb 2020

Eliminating American Foulbrood using Endolysins

In this case study, scientists identified an endolysin cell-binding domain that targets Paenibacillus larvae, the bacterium responsible for American Foulbrood.

14 Feb 2020

Whole Genome Amplification in Forensics

Forensic studies usually work with small or trace amounts of sample. DNA from such samples can be limiting, making their analysis difficult. Whole genome amplification can provide solution to this problem by providing greater yields from small samples.

14 Feb 2020