Cell Biology

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New method to improve preclinical evaluation of CAR-T cell therapies

Ludwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-receptor (CAR) T cell therapies.

9 Nov 2020

Researchers show how encapsulated viruses hijack biosynthetic pathways in cells

Researchers from the Universities of Melbourne, York, Warwick and Oxford have shed light on how encapsulated viruses like hepatitis B, dengue and SARS-CoV-2 hijack the protein manufacturing and distribution pathways in the cell - they have also identified a potential broad spectrum anti-viral drug target to stop them in their tracks.

9 Nov 2020

Ground-breaking discovery provides new understanding of how proteins operate

A ground-breaking discovery by Centenary Institute scientists has provided new understanding as to the nature of proteins and how they exist and operate in the human body.

9 Nov 2020

Unrelated mutations can lead to false positive results in men with advanced prostate cancer

Unrelated mutations, when present in the blood, can lead to false positive results in men with advanced prostate cancer who are undergoing liquid biopsies.

6 Nov 2020

Study shows how coronavirus block cells’ ability to produce protective proteins

One of the novel coronavirus' most insidious tricks is that it can block the ability of cells to produce protective proteins without hindering its own ability to replicate.

6 Nov 2020

Experts use super-resolution microscopy to observe individual synapse proteins

In the synapses of nerve cells (neurons), there are hundreds of specialized proteins that are important for the functioning of the nervous system. If something goes wrong here, neurological or psychiatric diseases can be the result - Alzheimer's and Parkinson's, depression, and schizophrenia are just a few of them.

6 Nov 2020

LipiDiDiet project shows positive effects of nutrient intervention in early Alzheimer’s disease

Trial participants who received a multinutrient formulation over an extended period of time showed a significantly less rapid deterioration in cognitive performance than the patients in a control group, who received only a placebo.

6 Nov 2020

Researchers outline the future effects of global warming on major cancers

Climate change will bring an acute toll worldwide, with rising temperatures, wildfires and poor air quality, accompanied by higher rates of cancer, especially lung, skin and gastrointestinal cancers, according to a new report from UC San Francisco.

6 Nov 2020

Researchers reveal identity of the last unknown protein of autophagy

Drs. Nobuo Noda (Director) and Kazuaki Matoba (Senior Researcher) et al. at the Institute of Microbial Chemistry (BIKAKEN, Tokyo, Japan) discovered that Atg9, one of the proteins that function to mediate autophagy, has phospholipid-translocation activity (the lipid scramblase activity) between the two layers of the lipid bilayer and elucidated that the protein's activity brings about autophagosome membrane expansion.

5 Nov 2020

Teratomas could provide a new glance at human development

Finding just the right model to study human development--from the early embryonic stage onward--has been a challenge for scientists over the last decade.

From UC San Diego 5 Nov 2020

Researchers identify a new solution for treating ligament injuries

Ligament injuries that affect scores of regular citizens and athletes are sidelined every year. Added to this, recovery is painful and takes a long time and, at times, a return to normal function is never achieved because of the formation of scars—an aspect that makes ligament injuries inclined to more damage.

4 Nov 2020

Computational method reveals a new hallmark of aging

While all human beings share changes during aging, like wrinkles, gray hair, and a general drop in function, aging is assumed to be the outcome of a cellular process.

4 Nov 2020

Researcher creates “leaf profile” of components involved in CO2 journey

During the process of photosynthesis, leaves trap the atmospheric carbon dioxide (CO2) and convert it into organic compounds.

4 Nov 2020

Study shows memory T cells are formed earlier than previously thought

A person will acquire immunity to a specific disease when T cells develop into memory cells after making contact with pathogens.

4 Nov 2020

Mature SARS-CoV-2 particle development by host-protein interactions

The proteins of SARS-CoV-2 play a key role in self-arrangement and particle formation, and current work suggests that an assembly is formed in the lipid bilayer of the endoplasmic reticulum.

3 Nov 2020

Similarities between animal and plant immune systems go beyond sensing

Max Planck Institute for Plant Breeding Research (MPIPZ) and University of Cologne researcher Takaki Maekawa and colleagues have discovered that plants have independently evolved a family of immune proteins that are strikingly similar to animals.

3 Nov 2020

Pancreatic cancer cells avert starvation by signaling to nerves, shows study

Pancreatic cancer cells avert starvation by signaling to nerves, which grow into dense tumors and secrete nutrients. This is the finding of a study with experiments in cancer cells, mice, and human tissue samples published online on November 2 in Cell.

3 Nov 2020