Cell Biology

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Single-nucleus RNA sequencing helps compare transcriptional responses to acute cocaine

The lab of Jeremy Day, Ph.D., at the University of Alabama at Birmingham, has used single-nucleus RNA sequencing approaches to compare transcriptional responses to acute cocaine in 16 unique cell populations from a portion of the brain called the nucleus accumbens, or NAc.

From University of Alabama 10 Jul 2020

Study explains why human mitochondrial genomes mutate frequently

One could say that mitochondria, the energy-producing organelles inside every human cell, dance to their own beat.

10 Jul 2020

TMEM106B gene reveals the causes of neurodegenerative diseases

Across the globe, approximately 50 million people are living with dementia. The two most common forms are Alzheimer's disease and frontotemporal lobar degeneration (FTLD), which develop when neurons in specific parts of the brain stop functioning - triggering memory loss and other behavioral or personality changes.

10 Jul 2020

High concentrations of blood sodium can influence the biological clock of mice

A new study from McGill University shows that increases in the concentrations of blood sodium can have an influence on the biological clock of mice, opening new research avenues for potentially treating the negative effects associated with long-distance travel or shift work.

10 Jul 2020

Expansion stress promotes immunosuppression and enhances growth of breast cancer cells

Expansion stress can have an alarming impact on breast cancer cells by creating conditions that could lead to dangerous acceleration of the disease, an interdisciplinary team of University of Alabama at Birmingham researchers has found.

10 Jul 2020

CU scientists identify key role of brain's immune cells during development

Researchers at the University of Colorado School of Medicine have identified how specific brain cells interacting during development could be related to neurological and neuropsychiatric diseases, including some that occur later in life.

10 Jul 2020

Preventing immune cell reprogramming could be a new way to stop breast cancer metastasis

Natural killer cells, a type of immune cell, are known to limit metastasis by inducing the death of cancer cells. But metastases still form in patients, so there must be ways for cancer cells to escape.

10 Jul 2020

ASC-enriched fat grafts for breast augmentation could produce superior results

Results of a clinical trial released today in STEM CELLS Translational Medicine indicates that breast augmentation in patients treated with fat grafts enriched with autologous adipose-derived stem cells (ASCs) had significantly superior results compared to those treated with non-enriched grafts.

9 Jul 2020

New type of molecular editor can make precise changes in mitochondrial DNA

The genome in mitochondria -- the cell's energy-producing organelles -- is involved in disease and key biological functions, and the ability to precisely alter this DNA would allow scientists to learn more about the effects of these genes and mutations.

9 Jul 2020

Bacteria-induced cell fusion provokes the immune system and causes host cell destruction

Burkholderia pseudomallei is a bacterium in the soil that causes melioidosis, a tropical disease with high morbidity and mortality.

9 Jul 2020

Study shows engineered natural killer immune cells can directly kill tumor cells

According to a study, researchers have successfully designed natural killer immune cells that destroy head and neck tumor cells in mice.

8 Jul 2020

SOAT1 enzyme offers a promising therapeutic target for pancreatic cancer

Researchers from CSHL have discovered that the growth of pancreatic cancer cells can be stopped by disrupting the way cholesterol is stored by the cells.

8 Jul 2020

Protein PRC1 acts as a 'viscous glue' during cell division, research shows

An over-abundance of the protein PRC1, which is essential to cell division, is a telltale sign in many cancer types, including prostate, ovarian, and breast cancer.

8 Jul 2020

Salk researchers discover genetic 'dial' to fine-tune the immune response

The human immune system is a finely-tuned machine, balancing when to release a cellular army to deal with pathogens, with when to rein in that army, stopping an onslaught from attacking the body itself.

8 Jul 2020

New assay helps study adhesion of cells

Fluorescent tagging is a powerful way of analyzing communications between cells. This method enables the analysis of numerous cell populations.

7 Jul 2020

Study reveals how stem cells are defined by collective cell dynamics

Human life without stem cells is unimaginable. Thanks to stem cells, a cluster of cells turns into an organ, and tissues of the human body can be renewed.

7 Jul 2020

Study shows how motor proteins function in their native crowded cell environments

Several diseases, including neurodegenerative disorders, have been associated with the defective functioning of motor proteins involved in cell transport.

From New York University (NYU) 7 Jul 2020

Brain's dedicated immune cells clear paths through 'scaffolding' to let neurons talk

To make new memories, our brain cells first must find one another. Small protrusions that bud out from the ends of neurons' long, branching tentacles dock neurons together so they can talk.

7 Jul 2020

DNA repair tool is tailored to deal with specific type of complex break, study shows

Our cells are constantly dividing, and as they do, the DNA molecule - our genetic code - sometimes gets broken. DNA has twin strands, and a break in both is considered especially dangerous.

7 Jul 2020

BU researchers develop new way to better understand human cell communication

Researchers from Boston University School of Medicine have developed and implemented a new way to better understand how human cells communicate with each other, how this communication is disrupted in human diseases and how this can be corrected pharmacologically.

7 Jul 2020

Cell Biology

Single-nucleus RNA sequencing helps compare transcriptional responses to acute cocaine

Study explains why human mitochondrial genomes mutate frequently

TMEM106B gene reveals the causes of neurodegenerative diseases

High concentrations of blood sodium can influence the biological clock of mice

Expansion stress promotes immunosuppression and enhances growth of breast cancer cells

CU scientists identify key role of brain's immune cells during development

Preventing immune cell reprogramming could be a new way to stop breast cancer metastasis

ASC-enriched fat grafts for breast augmentation could produce superior results

New type of molecular editor can make precise changes in mitochondrial DNA

Bacteria-induced cell fusion provokes the immune system and causes host cell destruction

Study shows engineered natural killer immune cells can directly kill tumor cells

SOAT1 enzyme offers a promising therapeutic target for pancreatic cancer

Protein PRC1 acts as a 'viscous glue' during cell division, research shows

Salk researchers discover genetic 'dial' to fine-tune the immune response

New assay helps study adhesion of cells

Study reveals how stem cells are defined by collective cell dynamics

Study shows how motor proteins function in their native crowded cell environments

Brain's dedicated immune cells clear paths through 'scaffolding' to let neurons talk

DNA repair tool is tailored to deal with specific type of complex break, study shows

BU researchers develop new way to better understand human cell communication

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