Cell Biology

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Persistent tumor mutation load may help predict outcome of novel immunotherapies

Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient's response to immunotherapy.

27 Jan 2023

Researchers use artificial human skin to block invasive tumor growth in skin cancer model

By using artificial human skin, a research group from the University of Copenhagen have managed to block invasive growth in a skin cancer model.

27 Jan 2023

Researchers discover new transporter for recycling of bacterial cell wall

A transporter which some bacteria use to recycle fragments of their cell wall has been discovered by researchers at Umeå University, Sweden.

27 Jan 2023

Figuring out how cells safeguard their genomes during replication

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome, a cell’s complete set of DNA, is most vulnerable while it is being duplicated before a cell divides.

26 Jan 2023

New insights into cell health and disease

Scientists from Weill Cornell Medicine have discovered a protein that not only prepares DNA for replication but also controls the replication process. The research, which was published on January 5th, 2023, in the journal Molecular Cell, resolves a puzzle that has long-baffled biologists.

26 Jan 2023

Study sheds new light on a lifestyle switch that occurs in marine bacteria

Scientists have detailed a lifestyle switch that occurs in marine bacteria, where they change from coexisting with algae hosts in a mutually beneficial interaction to suddenly killing them.

25 Jan 2023

Researchers use supercomputer to unveil new methods for DNA mosaic recognition

As humans, we each have trillions of cells. And each cell has a nucleus with individual genetic information –DNA – that can mutate to create an abnormality.

25 Jan 2023

New genetic condition that raises vulnerability to opportunistic infections

An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including life-threatening fungal pneumonia.

24 Jan 2023

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases.

From Ubiquigent Limited 23 Jan 2023

Utilizing "cyborg cells" in environment protection and medicine

At the University of California, Davis, biomedical engineers have developed “cyborg cells” that are partially alive.

From The University of California, Davis 19 Jan 2023

New revelations on the immune system’s defenses against infections

Cells competing for a place in a germinal center confront a tough admissions process. Germinal centers, which form following exposure to a pathogen or vaccine, serve as a kind of immune system training academy, assisting B cells in refining their response to the threat.

18 Jan 2023

Interpretable framework to investigate the spatial organization of cells

In cells that are similar in form and function throughout tissues and organs, genes that are activated and expressed produce patterns. Identifying these patterns increases the understanding of cells, which could lead to the discovery of disease mechanisms.

18 Jan 2023

Grasping how a biological pathway causes stem cells to regenerate or die

According to a recent study conducted by Cedars-Sinai and the University of California, San Francisco (UCSF), altering a cellular process can cause stem cells, which are the cells that give rise to all other types of body cells, to either die or regenerate.

18 Jan 2023

Intracellular drug delivery using a novel nano transporter

The effectiveness of a novel nano molecule as a drug delivery system has been examined in a recent study by the University of Barcelona.

From University of Barcelona 13 Jan 2023

A new-found possibility for viral and cancer drug therapies

Researchers have found that sugar-based molecules can be used to inhibit the activity of a cell receptor that plays a role in the emergence of a variety of viral infections and cancers.

13 Jan 2023

The continued functioning of circadian clock of cells even after starvation

According to a study that was just published in eLife, cells that have a functioning molecular clock are better able to adapt to changes in glucose supply and can recover from long-term starvation more quickly.

11 Jan 2023

New molecular profile of endometriosis to help improve therapeutic options

At Cedars-Sinai, a special and elaborate molecular profile of endometriosis has been engineered by investigators to help enhance therapeutic options for the millions of women suffering from the disease.

11 Jan 2023

Novel blood biomarker predicts a favorable response to CART cell therapy

A MedUni Vienna research group identified a particularly potent biomarker for clinical response to CAR-T cell therapy, establishing the conditions for the most effective use of this innovative therapy for lymphoma treatment.

11 Jan 2023

Analyzing the success rate of cell-cell metabolite exchange

It is said that when there is an exchange of metabolic products of the cells with other cells, their lifespan gets longer. This discovery has been given by a research group at Charité – Universitätsmedizin Berlin, which made the breakthrough in a study with the help of yeast cells.

11 Jan 2023

Investigating the molecular mechanisms that govern cilia force sensing

Although the human body is superficially symmetric along the left–right axis, most internal organs, including the heart, lungs, liver, stomach, and brain, have noteworthy left–right asymmetries in their structure and placement.

6 Jan 2023