Cell Biology

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Review: Role of Alternative Splicing Defects in Major Neurodegenerative Diseases

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs -; single-stranded RNAs involved in protein synthesis -; and proteins from the same stretch of DNA, plays an important role in molecular biology.

21 Jun 2023

Microglial Cells Serve as a Stable Viral Reservoir for Latent HIV

Human immunodeficiency virus-1 (HIV) introduces a copy of its DNA into human immune cells as part of its life cycle. Some of these newly infected immune cells can subsequently enter an inactive, latent state for an extended length of time, which is known as HIV latency.

19 Jun 2023

cBAF Protein Complex Controls the Fate of T Cells

The immune system protects the body from intruders, like bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs. Cytotoxic T cells are specialized immune cells that can grow into short-lived effector cells that destroy infected or malignant cells in human bodies.

14 Jun 2023

iPSC-Based Model System Helps Study Lung-Specific Mesenchyme

Lung mesenchymal cells, which are crucial components of the lung’s distinctive structure, also play a significant role in disease and injury recovery, but research into their biology and how they start disorders like pulmonary fibrosis is limited.

14 Jun 2023

Reengineering the Cellular Synthetic Machinery to Produce Never-Before-Seen Polymers

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals -; from fuels to fabrics and drugs -; beyond the normal repertoire of microbes.

14 Jun 2023

Heat-Damaged DNA in Food Linked to Possible Genetic Risks

Researchers have newly discovered a surprising and potentially significant reason why eating foods frequently cooked at high temperatures, such as red meat and deep-fried fare, elevates cancer risk. The alleged culprit: DNA within the food that's been damaged by the cooking process.

14 Jun 2023

Study Provides Evidence for Involvement of p53/p16/RB-E2F-DREAM Repressional Targets in Cellular Senescence

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

14 Jun 2023

Study Revolutionizes the Understanding of Immune Signaling

A study led by Daniel Jane-Wit, MD, PhD, associate professor of medicine (cardiology) and of immunobiology, could revolutionize our understanding of immune signaling.

14 Jun 2023

Photoacoustic Spectral Analysis Shows Promise for Noninvasive Diagnosis of Tumors

Tumors are not just isolated clumps of abnormal cells but are associated with more complex system known as the "tumor microenvironment" (TME).

14 Jun 2023

Study Sheds Light on the Genetic Basis for Body Plan Development in the Starlet Sea Anemone

Lacking bones, brains, and even a complete gut, the body plans of simple animals like sea anemones appear to have little in common with humans and their vertebrate kin.

14 Jun 2023

Preservation of Genetic Variation in Species and the Effects on Adaptation

Zachariah Gompert, an evolutionary geneticist at Utah State University, stated that genetic diversity is the ultimate source of energy for evolution.

13 Jun 2023

Exploring the Regulatory Mechanism and Physiological Significance of P62 Phosphorylation

Nuclear factor erythroid 2-related factor 2 (NRF2) is a master transcription factor with a role in maintaining oxidative stress response. It can be triggered by both redox-dependent and redox-independent pathways.

13 Jun 2023

New Method for Cell Type-Specific Mapping of Ion Distribution in Plants

Plant roots play a critical role in taking up, selecting, enriching and retaining a range of different mineral elements thereby supplying distant plant tissues with nutrients while sequestering excessive amounts of metals.

13 Jun 2023

Achieving 3D Printing Inside 'Mini-Organs' Growing in Hydrogels

Scientists from the NIHR Great Ormond Street Hospital Biomedical Research Centre (a collaboration between GOSH and UCL), London, and University of Padova, Italy, have shown for the first time how 3D printing can be achieved inside 'mini-organs' growing in hydrogels -- controlling their shape, activity, and even forcing tissue to grow into 'molds.'

12 Jun 2023

New Stem Cell Technique to Revolutionize Stem Cell Research

Studies of the interaction between human genetics and biology on a wide scale have been made possible by a potent new stem cell technology.

12 Jun 2023

How Do Plants Resist Clubroot?

Scientists from the Chinese Academy of Sciences’ Institute of Genetics and Developmental Biology, spearheaded by Yuhang Chen and Jianmin Zhou, have demonstrated how plants fight clubroot, a significant root disease that threatens the productivity of Brassica crops like rape.

12 Jun 2023

Human Pluripotent Stem Cells Converted into Purified Pituitary Tissue

Human pluripotent stem cells were effectively transformed into purified pituitary cells, which aggregated into hormone-secreting organoids.

9 Jun 2023

Key Atomic Structures of the Actin Filament Revealed Through Cryo-EM

Actin filaments -; protein structures critical to living movement from single cells to animals -; have long been known to have polarity associated with their physical characteristics, with growing "barbed" and shrinking "pointed" ends.

9 Jun 2023

Scientists Discover a New Step in the Differentiation of Precursor Cells Into Mature Basophils

Big changes often happen in small steps, and it's not always easy to see how we get from point A to point B.

8 Jun 2023

Novel Technique Overcomes Challenges of Bioprinting

Printing living cells into functional tissues is a highly complex process, and with each technological advancement, new challenges emerge. The Levato lab at UMC Utrecht has successfully combined two promising printing processes to boost cell density, cell survival, and specialization in bioprints. The solution: granular biogels or resins.

8 Jun 2023

Cell Biology

Review: Role of Alternative Splicing Defects in Major Neurodegenerative Diseases

Microglial Cells Serve as a Stable Viral Reservoir for Latent HIV

cBAF Protein Complex Controls the Fate of T Cells

iPSC-Based Model System Helps Study Lung-Specific Mesenchyme

Reengineering the Cellular Synthetic Machinery to Produce Never-Before-Seen Polymers

Heat-Damaged DNA in Food Linked to Possible Genetic Risks

Study Provides Evidence for Involvement of p53/p16/RB-E2F-DREAM Repressional Targets in Cellular Senescence

Study Revolutionizes the Understanding of Immune Signaling

Photoacoustic Spectral Analysis Shows Promise for Noninvasive Diagnosis of Tumors

Study Sheds Light on the Genetic Basis for Body Plan Development in the Starlet Sea Anemone

Preservation of Genetic Variation in Species and the Effects on Adaptation

Exploring the Regulatory Mechanism and Physiological Significance of P62 Phosphorylation

New Method for Cell Type-Specific Mapping of Ion Distribution in Plants

Achieving 3D Printing Inside 'Mini-Organs' Growing in Hydrogels

New Stem Cell Technique to Revolutionize Stem Cell Research

How Do Plants Resist Clubroot?

Human Pluripotent Stem Cells Converted into Purified Pituitary Tissue

Key Atomic Structures of the Actin Filament Revealed Through Cryo-EM

Scientists Discover a New Step in the Differentiation of Precursor Cells Into Mature Basophils

Novel Technique Overcomes Challenges of Bioprinting

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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