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Scientists Develop EvoCAST for Efficient and Accurate Gene Insertion

Ask scientists what gene editing tool is most needed to advance gene therapy, and they'd probably describe a system that's now close to realization in the labs of Samuel Sternberg at Columbia University Vagelos College of Physicians and Surgeons and David Liu at the Broad Institute of MIT and Harvard.

16 May 2025

Visualizing Intracellular Molecular Landscapes in Single Cells

The t-SPESI method enables real-time visualization of intracellular lipids, offering insights into disease mechanisms and improving diagnostic tool development.

15 May 2025

Light-Based 3D Printing for Precise Cellular Organization in Tissue Engineering

The Terasaki Institute's light-based 3D printing method advances tissue engineering, enabling tailored microgels for effective tissue repair and regeneration.

14 May 2025

DiffInvex Reveals Genetic Escape Routes Used by Tumors Against Treatment

Just as species adapt over generations, our body's cells accumulate DNA changes throughout life. Most are harmless, yet a few "driver" mutations give a cell a competitive edge and can spark cancer.

14 May 2025

Danforth Technology Company Backs Startup Transforming Crop Genetics

The Danforth Technology Company (DTC) today announced the launch of Spearhead Bio, a startup pioneering a breakthrough platform to enhance the efficiency of crop genome engineering by harnessing the plant's own natural DNA.

14 May 2025

AI Designs Synthetic DNA to Control Gene Expression in Mammalian Cells

A study published today in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells.

10 May 2025

Scientists Use AI to Predict Future Viruses and Design Better Vaccines

Effective vaccines dramatically changed the course of the COVID-19 pandemic, preventing illness, reducing disease severity, and saving millions of lives.

10 May 2025

New Ultraspeed Method for Bacterial Disease Diagnosis

Researchers from the Technical University of Munich (TUM) and Imperial College London have created a novel method for identifying bacteria with remarkable speed, significantly reducing the waiting time from several days to just a few minutes.

7 May 2025

New Gene Editing Tool Alters Mitochondrial Mutation Levels in Stem Cells

Mitochondrial diseases affect approximately 1 in 5,000 people worldwide, causing debilitating symptoms ranging from muscle weakness to stroke-like episodes.

5 May 2025

New Mass-Spectrometry Technique Boosts Enzyme Screening Speed by Up to 1000 Times

Scientists have developed a new technique to screen engineered enzyme reactions, which could lead to faster and more efficient creation of medicines and sustainable chemicals.

30 Apr 2025

New Software Tool Helps Scientists Identify Aging Cells in Tissues

For human health, prematurely aging cells are a big problem. When a cell ages and stops growing, its function changes, which can cause or worsen cardiovascular disease, Alzheimer’s disease and other chronic diseases.

29 Apr 2025

AI-Powered Protein Engineering for Precise and Scalable Gene Therapy

Genome editing has progressed rapidly, showing promising outcomes for the treatment of genetic disorders, yet there remains potential for enhancement.

23 Apr 2025

Researchers Develop STITCHR to Insert Whole Genes Without Unwanted Mutations

Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations.

12 Apr 2025

Breakthrough Delivery System Advances CRISPR-Based Treatments

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before.

10 Apr 2025

DNA Computing Circuits Move Closer to Real-Time Function Inside Living Cells

A comprehensive review titled "From the Test Tube to the Cell: A Homecoming for DNA Computing Circuits?" published Mar. 4 in Intelligent Computing, a Science Partner Journal, highlights progress in operating DNA computing circuits for operation within living cells.

9 Apr 2025

Novel Acoustic Technology Accelerates Biomedical Research

Engineers from a University of Bristol spin-out company have developed a new technology that manipulates cells without physical contact, allowing essential tasks—typically performed with bulky lab equipment—to be completed using a compact benchtop device.

7 Apr 2025