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Innovative Alternative Gene Editing Approach May Be Safer Than CRISPR

Genetic editing holds promise to treat incurable diseases, but the most popular method - CRISPR - sometimes does more harm than good.

22 Sep 2025

Novel Chromosome Identification System Overcomes Longstanding Bottleneck in Alfalfa Cytogenetics

Karyotype analysis is fundamental to understanding genetic makeup, diversity, and adaptation in plants. Yet, distinguishing individual chromosomes remains challenging in species with small, uniform chromosomes and complex polyploid genomes such as alfalfa.

22 Sep 2025

Advanced Statistical Method Reduces Noise in Single-Cell RNA-Sequencing Data

The world of cells is surprisingly noisy. Each cell carries unique genetic information, but when we try to measure cellular activity, signals can be lost or blurred, and differences between experiments can further obscure the data.

18 Sep 2025

Modified Cas9 Proteins Dramatically Lower Error Rates in Prime Editing

A genome-editing technique known as prime editing holds potential for treating many diseases by transforming faulty genes into functional ones.

18 Sep 2025

Molecular Simulations and AI Reveal Rapid Activation of Catch-Bonds Under Force

Imagine tugging on a Chinese finger trap. The harder you pull, the tighter it grips. This counterintuitive behavior also exists in biology.

13 Sep 2025

Engineered Base Editor Corrects ACTA2 Mutation in Rare Childhood Disease

Multisystemic smooth muscle dysfunction syndrome (MSMDS) is a rare condition associated with stroke, aortic dissection (tearing) and death in childhood.

13 Sep 2025

Adaptive Microfluidic Channel Enhances Impedance Flow Cytometry Sensitivity

Many advances in medicine and drug development were possible owing to flow cytometry, a single-cell analysis technique that analyzes cells using the emitted fluorescence of their chemical tags while passing through a laser beam.

13 Sep 2025

New Genomic Analysis Platform Launched for Tracking for Zoonotic Pathogens

Zoonotic pathogens, capable of crossing between animals and humans, pose escalating threats due to antimicrobial resistance, genetic diversification, and complex transmission patterns.

11 Sep 2025

PhoBITs Enable Unprecedented Control of Cellular Pathways with Blue Light

Imagine being able to flip a light switch to control disease pathways inside a living cell. A team of visionary researchers at the Texas A&M University Health Science Center (Texas A&M Health) is making this dream a reality with their groundbreaking genetic tools known as photo-inducible binary interaction tools, or PhoBITs.

10 Sep 2025

Predicting Protein Metal Binding with New Artificial Intelligence Model

Biologists and computational scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory recently refined two artificial intelligence (AI) programs originally built by Meta, the company that owns Facebook, to predict protein shapes.

10 Sep 2025

Researchers Develop New Technique to Detect Causality in Neural Spike Trains

Understanding the brain's functional architecture is a fundamental challenge in neuroscience. The connections between neurons ultimately dictate how information is processed, transmitted, stored, and retrieved, thus forming the basis of our cognitive functions.

10 Sep 2025

Scientists Engineer E. Coli To Produce Plastic-Building Chemical

This study reveals a novel pathway in E. coli for synthesizing 2,5-pyridinedicarboxylate from glucose, offering a sustainable alternative to fossil fuels.

10 Sep 2025

spVelo: A New Method for Integrating Spatial and Temporal Data in RNA Velocity Analysis

Essentially all cells in an organism's body have the same genetic blueprint, or genome, but the set of genes that are actively expressed at any given time in a cell determines what type of cell it will be and its function.

8 Sep 2025

AI Tool for Designing Antibiotics from Scratch

In a recent Cell Biomaterials study, University of Pennsylvania researchers offer AMP-Diffusion, a generative AI tool for creating tens of thousands of novel antimicrobial peptides (AMPs) — short strings of amino acids that serve as the building blocks of proteins — with bacteria-killing capability.

3 Sep 2025