Drug Discovery & Pharmaceuticals

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Already characterized active substances exhibit unexpected effects

Every innovative drug starts with the search for an active substance targeting key players in disease-related processes.

23 Jul 2021

Determining class A drug use from a single fingerprint

AZoLifeSciences speaks to Dr. Catia Costa about her latest research that showed how class A drug use can be determined from a single fingerprint.

From University of Surrey 29 Jun 2021

Mayo Clinic researchers examine potential new CAR-T cell treatment for multiple myeloma

Researchers at Mayo Clinic Cancer Center are studying a potential new chimeric antigen receptor-T cell therapy (CAR-T cell therapy) treatment for multiple myeloma.

28 Jun 2021

WEHI partners with Boehringer Ingelheim to develop novel anti-cancer therapeutics

WEHI has partnered with Boehringer Ingelheim, a leading research-driven pharmaceutical company, in a collaboration to discover and develop anti-cancer therapeutics using a promising new technology called targeted protein degradation.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 25 Jun 2021

New technique boosts the efficacy of future malaria vaccines

A new technique for obtaining pure malaria parasites from infected mosquitos could speed up the development of novel, more powerful malaria vaccinations.

21 Jun 2021

Researchers discover new way to improve absorption and brain delivery of medicinal cannabis

A team of researchers led by Curtin University has discovered a new way to improve the absorption rate of medicinal cannabis when taken orally, which could potentially be used to treat neurological disorders such as Alzheimer’s disease, multiple sclerosis and traumatic brain injuries in the future.

21 Jun 2021

NIH grant awarded to model and analyze protein-ligand interactions in cancer research

Computer scientist Lydia Kavraki of Rice University's Brown School of Engineering has won a prestigious National Institutes of Health U01 grant to develop a new approach to model and analyze protein-ligand interactions in cancer research.

8 Jun 2021

Scientists discover two drugs that provide effective SARS-CoV-2 suppression

COVID-19 continues to claim lives across the world and is infecting millions more. Although several vaccines have recently become available, making significant strides towards preventing COVID-19, what about the treatment of those who already have the infection?

From Tokyo University of Science 4 Jun 2021

Immunotherapy following kidney cancer surgery prolonged disease-free survival rates

Treatment with an immunotherapy drug following kidney cancer surgery, prolonged disease-free survival rates in patients at high risk for recurrence, according to an interim report of a phase 3 clinical trial of adjuvant immunotherapy in this patient population.

4 Jun 2021

Immune therapy after surgery reduces recurrence risk in patients with high-risk melanoma

Patients with high-risk melanoma who had a course of pembrolizumab after their surgery had a longer time before their disease recurred than patients who got either ipilimumab or high-dose interferon after surgery. These findings of a large SWOG Cancer Research Network clinical trial, S1404, will be presented at the ASCO annual meeting June 6, 2021.

4 Jun 2021

Novel drug is highly effective in preventing severe COVID-19 in mice

The drug diABZI -- which activates the body's innate immune response -- was highly effective in preventing severe COVID-19 in mice that were infected with SARS-CoV-2,

31 May 2021

Many do not recognise animal agriculture's link to infectious diseases

New research led by the University of Kent has found that people fail to recognize the role of factory farming in causing infectious diseases.

14 May 2021

New drug-like compound designed to stop malaria in its tracks

Researchers at the Francis Crick Institute and the Latvian Institute of Organic Synthesis have designed a drug-like compound which effectively blocks a critical step in the malaria parasite life cycle and are working to develop this compound into a potential first of its kind malaria treatment.

13 May 2021

Novel peptide could allow cannabis to relieve pain while avoiding side effects

Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions.

13 May 2021

Newly designed higher affinity monoclonal antibody for cancer treatment

Recently, Prof. XIE Can from the High Magnetic Field Laboratory of the Hefei Institutes of Physical Science (HFIPS), in a collaboration with Prof. YAN Xiyun's lab from the Institute of Biophysics, reported the structural basis of mAb AA98's inhibition on CD146-mediated endothelial cells (EC) activation and designed higher affinity monoclonal antibody HA98 for cancer treatment.

10 May 2021

Developing a portable tool to detect street drug ‘spice’

AZoLifeSciences speaks to researchers from the University of Bath about their latest research that led to the development of a device that can detect 'spice'.

From University of Bath 28 Apr 2021

Researchers hope to make estrogen therapy a more accessible treatment for breast cancer patients

Researchers at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center (NCCC) hope to make estrogen therapy a more accessible treatment option for breast cancer patients who could benefit from it.

26 Apr 2021

Study sheds light on the ability of cannabidiol to reduce pain

It's been hailed as a wonder drug and it's certainly creating wonder profits. By some estimates, the Cannabidiol (or CBD) market could be worth $20 billion dollars by 2024. While users tout its effectiveness in pain relief, up until now there's been limited experimental human research on the actual effectiveness of the drug

26 Apr 2021

Researchers identify and test drug combination that exploits a weakness in small cell lung cancer

Researchers from the National Institutes of Health have identified and tested a drug combination that exploits a weakness in small cell lung cancer (SCLC), an aggressive, dangerous cancer.

13 Apr 2021

New AI-based method can lead to faster, low-cost development of protein-based drugs

Thanks to a newly published study by scientists, artificial intelligence (AI) can now create novel and functionally active proteins.

1 Apr 2021