Drug Discovery & Pharmaceuticals

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DNA Cassettes Enable Long-Lasting Antibody Production Directly Inside Patients

A multidisciplinary team of scientists led by The Wistar Institute, including Perelman School of Medicine at the University of Pennsylvania, AstraZeneca and Inovio Pharmaceuticals, published today in Nature Medicine a breakthrough in biologic antibody production that happens directly in human subjects in this encouraging first clinical trial of its kind.

23 Oct 2025

New AI Model Unlocks the Therapeutic Potential of Lasso Peptides

In the hunt for new therapeutics for cancer and infectious diseases, lasso peptides prove to be a catch.

17 Oct 2025

Task-Specific Machine Learning Architecture Enhances Drug Discovery Accuracy

The drug development pipeline is a costly and lengthy process. Identifying high-quality "hit" compounds-those with high potency, selectivity, and favorable metabolic properties-at the earliest stages is important for reducing cost and accelerating the path to clinical trials.

17 Oct 2025

PapB Could Make Ozempic-Style Drugs Stronger and Last Longer

Chemistry researchers at the University of Utah have discovered an enzyme referred to as PapB, which is capable of "tying off" therapeutic peptides, drugs resembling proteins, into compact rings, a process termed macrocyclization.

17 Oct 2025

Framework Evaluating Economic and Environmental Sustainability of Medical Drugs

The production of medical drugs is costly and may negatively impact the environment. Researchers Stefano Cucurachi and Justin Lian have created a framework designed to assist the healthcare system in evaluating the economic and environmental sustainability of medical compounds.

16 Oct 2025

GlyTR Therapeutics Unveils Groundbreaking Glycan-Targeting Cancer Immunotherapy

GlyTR Therapeutics, a biotech company pioneering development of glycan-targeting cancer immunotherapies, announced the publication of its foundational technology in the journal, Cell.

14 Oct 2025

Antibody 04_A06 Neutralizes Nearly All Tested HIV Variants in Laboratory Studies

A Cologne-led research team has discovered the antibody 04_A06, which neutralizes the human immunodeficiency virus (HIV) in almost all tested variants in vitro and even overcomes typical resistance mechanisms.

7 Oct 2025

Comprehensive Proteomic Analysis with COOKIE-Pro Reveals Drug Affinity and Reactivity

Researchers at Baylor College of Medicine have developed a powerful new data analysis method named COOKIE-Pro (Covalent Occupancy Kinetic Enrichment via Proteomics) that provides a comprehensive, unbiased view of how a class of drugs, called covalent inhibitors, interacts with proteins throughout the cell.

30 Sep 2025

Concept Life Sciences Expands Integrated Drug Discovery Facilities

Concept Life Sciences, a leading contract research organisation (CRO) serving the global life sciences and pharma industry, today announces the official opening, by Jonathan Pearce, the Labor Member of Parliament for High Peak, of its expanded integrated drug discovery facilities at its Chapel-en-le-Frith site.

From Concept Life Sciences 29 Sep 2025

Advanced Workflow Automation and Scalable Image Analysis in Spatial Biology

ZEISS Microscopy and Concept Life Sciences, a UK-based contract research organization (CRO), announced their collaboration aimed at pioneering new approaches to workflow automation and scalable image analysis in spatial biology.

From Concept Life Sciences 26 Sep 2025

Possible Breakthrough in the Development of Effective Biomaterials

Many hopes rested on so-called tissue engineering: With the help of stem cells, skin and other organs could be grown, thereby enabling better wound healing and better transplants.

19 Sep 2025

Axxam and B'SYS Partner to Expand Access to Validated Ion Channel Cell Lines for High-Throughput Electrophysiology

Axxam S.p.A., a premier provider of integrated early drug discovery services, and B'SYS GmbH, a specialist in ion channel biology, are pleased to announce a strategic collaboration focused on enabling access to validated ion channel cell lines for hit and lead identification through high-throughput electrophysiological screening.

From Axxam S.p.A 8 Sep 2025

BioDlink Expands Ecosystem Alliance to Empower Biotech Innovators Worldwide

As BioDlink, a leading global CDMO, affirms its commitment to strategic alliances to support biotech innovation worldwide as it marks 15 years of operations.

From BioDlink 5 Sep 2025

Aptamer Signs Therapeutic Development Agreement with Invizius

Aptamer Group plc, the developer of next-generation synthetic binders for the life sciences industry, is pleased to announce that it has signed a new therapeutic development agreement with Invizius, a clinical-stage biotechnology company focused on second-generation complement system therapies for inflammatory, fibrotic, and autoimmune diseases.

From Aptamer Group 2 Sep 2025

GEMORNA Platform Generates Novel mRNA Sequences With Superior Drug Properties

Raina Biosciences Inc., ("Raina"), an mRNA technology and therapeutics company, today announced the publication of data from its generative AI platform in Science.

28 Aug 2025

Emory Chemists Boost Synthesis of Vinylic Ethers for Drug Discovery

A new approach to an established reaction boosts the ability to synthesize vinylic ethers - key building blocks for many molecules important to human health.

28 Aug 2025

Aptamer Group Introduces Novel Biomarker Discovery Service

Aptamer Group plc, the leading developer of next-generation synthetic binders delivering innovation to the life science industry, today announced the launch of its biomarker discovery service, offering researchers in pharmaceutical, biotechnology, and diagnostic development an innovative approach to identify and validate new disease markers.

28 Aug 2025

Mitsui, QSimulate, and Quantinuum Launch “QIDO”: A Quantum-Integrated Chemistry Platform Targeting Faster Drug and Materials Discovery

Mitsui & Co., Ltd. (“Mitsui”), QSimulate, and Quantinuum today announced the launch of a new quantum-integrated chemistry platform, QIDO (Quantum-Integrated Discovery Orchestrator).

From Quantinuum Ltd 22 Aug 2025

Computational Modeling Creates a Database for Improved Detection of Designer Drugs

How do you identify something no one has a test for? Designer drugs replicate the effects of known, illicit drugs but evade law enforcement.

21 Aug 2025

New Molecules from the McMaster Greenhouse Target Drug-Resistant Fungi

A research team at McMaster University has discovered a new drug class that could someday lead to breakthrough treatments for dangerous fungal infections.

13 Aug 2025