Drug Discovery & Pharmaceuticals

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Breakthrough RNA-Based Vaccine Strategy Offers Universal Protection

Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised.

16 Apr 2024

Precision Combination Therapy Better Controls High-Risk Subtypes of B-ALL in Mouse Models

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

9 Apr 2024

Designing Compounds for Next-Gen Antibiotics and Cancer Treatments

Chemists at Cold Spring Harbor Laboratory (CSHL) have generated a novel set of molecular compounds and are evaluating them as possible candidates for novel drug discovery leads.

5 Apr 2024

Groundbreaking AI Framework Revolutionizes Drug Discovery

A transformative study published in Health Data Science, a Science Partner Journal, introduces a groundbreaking end-to-end deep learning framework, known as Knowledge-Empowered Drug Discovery, aimed at revolutionizing the field of drug discovery.

1 Apr 2024

Promising Compound Shows Potential in Reducing Alcohol Consumption

Scripps Research scientists have found that LY2444296-;a compound that selectively blocks the kappa opioid receptor (KOP)-;may reduce drinking in cases of alcohol dependence in animal studies.

30 Mar 2024

AI Predicts Multiple Protein Shapes, Boosting Drug Development

By understanding protein dynamics and functions, a group of academics at Brown University have devised a method for quickly predicting various protein configurations using machine learning.

28 Mar 2024

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way.

25 Mar 2024

$1.65 Million Grant Awarded for Advancing Therapeutic RNA Design

A team led by Dr. Samie Jaffrey, the Greenberg-Starr Professor of Pharmacology at Weill Cornell Medicine, has been awarded a three-year, $1.65 million grant for RNA research under a biotechnology-development program run by the U.S. National Science Foundation.

22 Mar 2024

DNA Origami Revolutionizes Cancer Immunotherapy: The DoriVac Breakthrough

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

Method Seeks to Eliminate the Need for Frozen mRNA Vaccines

CEPI has provided funding to a public research university in Belgium to investigate whether a novel vaccine stabilization method could eliminate the need for mRNA vaccines to be stored in frozen storage and enable a quick and expanded response to future outbreaks in as little as 100 days.

14 Mar 2024

Metrion Biosciences Strengthens Team with Three Key Appointments

Metrion Biosciences Limited (“Metrion”), the specialist ion channel contract research organisation (CRO) and drug discovery company, has promoted Clare Rutty to CFO and welcomes two new hires in Sue Peffer as Head of Marketing and Leanne Clarke as HR Officer.

12 Mar 2024

CSHL Researchers Unravel Why Some Splicing-Based Drugs Tend to Work Better Than Others

Spinal muscular atrophy, or SMA, is the leading genetic cause of infant death. Less than a decade ago, Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer showed this brutal disease can be treated by tweaking a process called RNA splicing.

6 Mar 2024

New "Tissue-in-a-CUBE" Offers Alternative to Animal Testing in Drug Development

A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in establishing a model of the blood-brain barrier using modularized tissue derived from human cells.

29 Feb 2024

Novel Antibiotic Discovery: Harnessing Energy Compounds to Combat Bacterial Infections

About a decade ago, researchers in UC Santa Barbara chemistry professor Guillermo Bazan's lab began to observe a recurring challenge in their research: Some of the compounds they were developing to harness energy from bacteria were instead killing the microbes.

22 Feb 2024

Scientists Develop Green Antibiotic Alternative to Treat Deadly Pathogen in Hybrid Striped Bass

Scientists at the United States Department of Agriculture (USDA)'s Agricultural Research Service (ARS) developed a green antibiotic alternative to treat the deadly pathogen Streptococcus iniae in hybrid striped bass, the fourth most farmed finfish in the United States, according to a recent study.

31 Jan 2024

Promising Drug Offers Hope for Overcoming Resistance to Protein Degraders

Protein degraders, a novel approach in drug discovery, show promise to tackle diseases previously thought to be untreatable.

31 Jan 2024

Scientists Create "Immunologically Silent" DNA Vaccine for Potent Virus Defense

Using a virus-like delivery particle made from DNA, researchers from MIT and the Ragon Institute of MGH, MIT, and Harvard have created a vaccine that can induce a strong antibody response against SARS-CoV-2.

31 Jan 2024

Formulatrix® and Olink® Announce Collaboration to Deliver Automated Proteomics Research Solutions to Enable Protein Detection with Exceptional Precision and Speed

Formulatrix, a leader in innovative automated liquid handling technologies, announced a multi-year collaboration and supply agreement to advance the automation of Olink’s PEA (Proximity Extension Assay) technology, including the Target 96, Target 48, Flex, and Explore workflows.

From FORMULATRIX 31 Jan 2024

Chemists Develop Two-Step Method to Create Promising Molecules for Life Sciences Research

Organic compounds in the field of chemistry range from simple hydrocarbons to complex molecules, with diverse functional groups added to the main carbon backbone.

30 Jan 2024

“Free-from-Tree” Production of Vaccine Component QS-21

For the first time, a valuable chemical extracted from the soapbark tree and utilized as a major component in vaccinations has been duplicated in a different plant host, providing the vaccine industry with hitherto unheard-of potential.

29 Jan 2024

Drug Discovery & Pharmaceuticals

Breakthrough RNA-Based Vaccine Strategy Offers Universal Protection

Precision Combination Therapy Better Controls High-Risk Subtypes of B-ALL in Mouse Models

Designing Compounds for Next-Gen Antibiotics and Cancer Treatments

Groundbreaking AI Framework Revolutionizes Drug Discovery

Promising Compound Shows Potential in Reducing Alcohol Consumption

AI Predicts Multiple Protein Shapes, Boosting Drug Development

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

$1.65 Million Grant Awarded for Advancing Therapeutic RNA Design

DNA Origami Revolutionizes Cancer Immunotherapy: The DoriVac Breakthrough

Method Seeks to Eliminate the Need for Frozen mRNA Vaccines

Metrion Biosciences Strengthens Team with Three Key Appointments

CSHL Researchers Unravel Why Some Splicing-Based Drugs Tend to Work Better Than Others

New "Tissue-in-a-CUBE" Offers Alternative to Animal Testing in Drug Development

Novel Antibiotic Discovery: Harnessing Energy Compounds to Combat Bacterial Infections

Scientists Develop Green Antibiotic Alternative to Treat Deadly Pathogen in Hybrid Striped Bass

Promising Drug Offers Hope for Overcoming Resistance to Protein Degraders

Scientists Create "Immunologically Silent" DNA Vaccine for Potent Virus Defense

Formulatrix® and Olink® Announce Collaboration to Deliver Automated Proteomics Research Solutions to Enable Protein Detection with Exceptional Precision and Speed

Chemists Develop Two-Step Method to Create Promising Molecules for Life Sciences Research

“Free-from-Tree” Production of Vaccine Component QS-21

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

Commercializing Innovation in a Life Sciences Ecosystem

Latest in Genomics