Drug Discovery & Pharmaceuticals

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Breakthrough: Sequencing Functional Antibody Proteins Directly from Human Blood

Rapid Novor Inc., the world’s leader in mass spectrometry (MS)-based antibody protein sequencing, announced today that its REpAb® antibody discovery platform was used to successfully sequence a complex mixture of functional antibodies directly from the serum of a human patient after receiving a COVID-19 vaccine.

6 Jun 2023

Using Synthetic Peptides in Next-Generation Inflammatory Disease Diagnostic Assays

Conditions like ulcerative colitis and Crohn's disease, which cause inflammation in the body, can be identified or tracked by measuring a protein called calprotectin.

29 May 2023

Failed Antibiotics Could Become Weed Killers in the Future

Weed killers of the future could soon be based on failed antibiotics.

25 May 2023

New Platform for Production of Synthetic Nitrated Proteins in Bacteria

In this study, the researchers focused on para-nitro-L-phenylalanine (pN-Phe), a non-standard amino acid that is neither one of the twenty standard amino acids nor been observed in nature.

24 May 2023

Identifying Drugs to Put the Brakes On Accelerated Aging From HIV Infection, Treatment

Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.

24 May 2023

Altered Anti-Nausea Drug can Penetrate Cells and Provide Sustained Pain Relief

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's Pain Research Center.

23 May 2023

Predictive Models to Determine the Structure, Stability, Flexibility and Biology of RNA-Targeted Drugs

Proteins are large, complex molecules that play many critical roles in the body and are produced following the instructions encoded in DNA.

18 May 2023

Long-Ignored Antibiotic may Provide Much-Needed Protection Against Multi-Drug Resistant Bacteria

An old antibiotic may provide much-needed protection against multi-drug resistant bacterial infections, according to a new study publishing May 16th in the open access journal PLOS Biology by James Kirby of Harvard Medical School, US, and colleagues.

17 May 2023

Study Finds Methylated CD Derivatives as Effective Stabilizers for Supersaturated Drugs

In the medicine market, most newly introduced drugs and drug candidates show poor water solubility, which prevents their absorption in the body. This, in turn, limits their therapeutic efficiency.

16 May 2023

Essential Oil From the Leaves of Labrador Tea Plant Has Antimalarial Properties

Much of what is now considered modern medicine originated as folk remedies or traditional, Indigenous practices. These customs are still alive today, and they could help address a variety of conditions.

12 May 2023

Using Mass-Spectrometry-Based Cancer Proteomics Datasets to Discover Potential Therapeutic Targets

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Using cancer proteomics data to identify gene candidates for therapeutic targeting."

11 May 2023

Scientists Engineer the First CRISPR-Based Drug Candidate to Directly Target E. Coli

Many people have experienced infections from E. coli, which are primarily seen as inconvenient and unpleasant.

10 May 2023

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer.

8 May 2023

New Insights on Cases of Post-Vaccine Heart Inflammation

Public health experts discovered an increase in cases of myocarditis, an inflammation of heart muscle, after the introduction of the new COVID-19 vaccinations two years ago, particularly in young males who had received mRNA vaccines.

8 May 2023

New AI System Could Help Advance the Field of Generative Biology

Researchers at the University of Toronto have developed an artificial intelligence system that can create proteins not found in nature using generative diffusion, the same technology behind popular image-creation platforms such as DALL-E and Midjourney.

5 May 2023

Multi-Angled Approach of Identifying Dual-Purpose Therapeutic Targets Implicated in Aging, Glioblastoma

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform."

3 May 2023

Drug Discovery & Pharmaceuticals

Breakthrough: Sequencing Functional Antibody Proteins Directly from Human Blood

Using Synthetic Peptides in Next-Generation Inflammatory Disease Diagnostic Assays

Failed Antibiotics Could Become Weed Killers in the Future

New Platform for Production of Synthetic Nitrated Proteins in Bacteria

Identifying Drugs to Put the Brakes On Accelerated Aging From HIV Infection, Treatment

Altered Anti-Nausea Drug can Penetrate Cells and Provide Sustained Pain Relief

Predictive Models to Determine the Structure, Stability, Flexibility and Biology of RNA-Targeted Drugs

Long-Ignored Antibiotic may Provide Much-Needed Protection Against Multi-Drug Resistant Bacteria

Study Finds Methylated CD Derivatives as Effective Stabilizers for Supersaturated Drugs

Essential Oil From the Leaves of Labrador Tea Plant Has Antimalarial Properties

Using Mass-Spectrometry-Based Cancer Proteomics Datasets to Discover Potential Therapeutic Targets

Scientists Engineer the First CRISPR-Based Drug Candidate to Directly Target E. Coli

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

New Insights on Cases of Post-Vaccine Heart Inflammation

New AI System Could Help Advance the Field of Generative Biology

Multi-Angled Approach of Identifying Dual-Purpose Therapeutic Targets Implicated in Aging, Glioblastoma

New Drug Development Method Could Lead to Cost-Effective Malaria Treatment

Argonne's Advanced Photon Source Helps Identify New Antibodies Against Coronaviruses

Newly Identified Broad-Spectrum Antivirals Can Target Multiple Families of RNA Viruses

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

CITES: Regulating the International Wildlife Trade to Preserve the Viability of Species

How can the adoption of AI technology accelerate drug discovery?

Gaining insights into human disease biology through CRISPR platforms

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