Drug Discovery & Pharmaceuticals

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Using a Data-Driven Approach to Accelerate the Design Process for New Drugs

Researchers have developed a platform that combines automated experiments with AI to predict how chemicals will react with one another, which could accelerate the design process for new drugs.

16 Jan 2024

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

Scientists Reinvent Spectinomycin as a Powerhouse Weapon for Drug-Resistant Superbug

Scientists at St. Jude Children's Research Hospital are tackling Mycobacterium abscessus (Mab) antibiotic resistance.

10 Jan 2024

EPFL Scientists Develop Platform for Orally Available Cyclic Peptide Drugs

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy.

29 Dec 2023

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

26 Dec 2023

New AI-Generated Proteins Could Revolutionize Medicine and Beyond

A new study Dec. 18 in Nature reports an AI-driven advance in biotechnology with implications for drug development, disease detection, and environmental monitoring.

19 Dec 2023

Free AI Drug Discovery Course Surpasses 2,500 Users

An online course on Disease Modeling and Target Discovery launched 7 months ago by clinical stage generative artificial intelligence (AI)-driven biotechnology company Insilico Medicine has surpassed 2,500 users.

12 Dec 2023

Presage Biosciences and AstraZeneca Partner to Advance Immuno-Oncology Research for Head and Neck Cancer

Presage Biosciences, a pioneering translational oncology company whose mission is to use CIVO and spatial molecular profiling to understand the complexity of drug response in the tumor microenvironment (TME), has entered into an agreement with AstraZeneca, a global biopharmaceutical company.

1 Dec 2023

New Computational Method Predicts the Stability of Pharmaceutical Crystalline Forms

Physical properties (stability, solubility, etc.), critical to the performance of pharmaceutical and functional materials, are known to strongly depend on the solid-state form and environmental factors, such as temperature and relative humidity.

13 Nov 2023

New Methods to Modify Molecular Structure Could Lead to More Tailored Drugs

For years, the top desire among those engaged in the development of pharmaceutical drugs was to find a simple method for substituting a carbon atom with a nitrogen atom in a molecule.

2 Nov 2023

Revolutionizing Drug Discovery: The Role of AI in Lead Optimization

Lead optimization in the field of drug discovery poses a formidable challenge, predominantly hinging on conjectures and the expertise of medicinal chemists.

25 Oct 2023

Yeast-Based Method Could Accelerate Discovery of Plant-Based Medicinal Compounds

Cornell researchers have harnessed the power of baker's yeast to create a cost-effective and highly efficient approach for unraveling how plants synthesize medicinal compounds, and used the new method to identify key enzymes in a kratom tree.

19 Oct 2023

Scientists Develop Novel Glycoengineering Platform to Revolutionize Vaccine and Therapeutic Production

A novel glycoengineering platform, created by the laboratory of Assistant Professor Chris Lok-To Sham from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), is poised to revolutionize future production of vaccines and therapeutics to fight infectious diseases.

17 Oct 2023

Pure Capped mRNA Vaccine Opens the Door to More Effective Vaccines with Lower Chances of Inflammation

A research group from Japan has developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA.

11 Oct 2023

Small Chemical Change to Boost Bioavailability of Drug Molecules

The effectiveness of any drug molecule depends on how well it interacts with the internal environment inside our body.

11 Oct 2023

Targeted MicroRNA-34a Therapy Shows Promise in Slowing Tumor Growth in Mice

A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division.

5 Sep 2023

MAGE Technology Helps Reveal the Potency of Antibiotics

By substituting each of the 20 amino acid alternatives found in nature for one of the 38 amino acid components that make up the rifampicin binding site on E. coli, the study authors were able to produce 760 distinct RNAP mutants. The development of this mutant pool was then examined under various circumstances, including rifampicin therapy.

31 Aug 2023

Waters Corporation and Princeton University Announce Multi-Year Research Collaboration

Waters Corporation announced a multi-year research collaboration with Princeton University that will enable scientists, faculty, and students to work together to bring their diverse skills and backgrounds to solve complex challenges in biochemistry and materials science.

From Waters Corporation 24 Aug 2023

AI Tool Speeds Up Vaccine Development

From tackling homework challenges to drafting emails, people are discovering a vast array of applications for natural language processing tools like generative artificial intelligence (AI) engines.

14 Aug 2023