Drug Discovery & Pharmaceuticals

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New Methods to Modify Molecular Structure Could Lead to More Tailored Drugs

For years, the top desire among those engaged in the development of pharmaceutical drugs was to find a simple method for substituting a carbon atom with a nitrogen atom in a molecule.

2 Nov 2023

Revolutionizing Drug Discovery: The Role of AI in Lead Optimization

Lead optimization in the field of drug discovery poses a formidable challenge, predominantly hinging on conjectures and the expertise of medicinal chemists.

25 Oct 2023

Yeast-Based Method Could Accelerate Discovery of Plant-Based Medicinal Compounds

Cornell researchers have harnessed the power of baker's yeast to create a cost-effective and highly efficient approach for unraveling how plants synthesize medicinal compounds, and used the new method to identify key enzymes in a kratom tree.

19 Oct 2023

Scientists Develop Novel Glycoengineering Platform to Revolutionize Vaccine and Therapeutic Production

A novel glycoengineering platform, created by the laboratory of Assistant Professor Chris Lok-To Sham from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), is poised to revolutionize future production of vaccines and therapeutics to fight infectious diseases.

17 Oct 2023

Pure Capped mRNA Vaccine Opens the Door to More Effective Vaccines with Lower Chances of Inflammation

A research group from Japan has developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA.

11 Oct 2023

Small Chemical Change to Boost Bioavailability of Drug Molecules

The effectiveness of any drug molecule depends on how well it interacts with the internal environment inside our body.

11 Oct 2023

Targeted MicroRNA-34a Therapy Shows Promise in Slowing Tumor Growth in Mice

A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division.

5 Sep 2023

MAGE Technology Helps Reveal the Potency of Antibiotics

By substituting each of the 20 amino acid alternatives found in nature for one of the 38 amino acid components that make up the rifampicin binding site on E. coli, the study authors were able to produce 760 distinct RNAP mutants. The development of this mutant pool was then examined under various circumstances, including rifampicin therapy.

31 Aug 2023

Waters Corporation and Princeton University Announce Multi-Year Research Collaboration

Waters Corporation announced a multi-year research collaboration with Princeton University that will enable scientists, faculty, and students to work together to bring their diverse skills and backgrounds to solve complex challenges in biochemistry and materials science.

From Waters Corporation 24 Aug 2023

AI Tool Speeds Up Vaccine Development

From tackling homework challenges to drafting emails, people are discovering a vast array of applications for natural language processing tools like generative artificial intelligence (AI) engines.

14 Aug 2023

New Breakthrough in Generative AI Models and AlphaFold Structures for Drug Discovery

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has achieved a significant breakthrough in the application of multiple generative AI models and AlphaFold structures for drug discovery.

3 Aug 2023

New Collaboration Aims to Advance Cancer Therapies Against Previously Undruggable Targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023

Analyzing the Possibility to Design Improved Vaccines

A new paper in Biology Methods & Protocols, published by Oxford University Press, shows it may be possible to design vaccines that will induce a stronger immune response to infecting pathogens, such as the virus causing COVID-19.

26 Jul 2023

Researchers Design New Algorithm to Boost Pandemic Preparedness

Immune system researchers have designed a computational tool to boost pandemic preparedness. Scientists can use this new algorithm to compare data from vastly different experiments and better predict how individuals may respond to disease.

26 Jul 2023

Researchers Make Breakthrough in Fight Against Familial Hypercholesterolemia

The Mona Lisa, painted by the Italian artist Leonardo da Vinci, is one of the most recognizable paintings in the world.

21 Jul 2023

New Vaccine Shows Promise in Combating MenB

Investigators from the Universities of Surrey and Oxford have declared that a vaccine candidate that can shield children from Meningococcal group B (MenB), which can cause meningitis, has advanced to clinical development.

19 Jul 2023

Government Backing UK Engineering Biology Firms to Revolutionise Medicine, Food and Environmental Protection

The UK firms harnessing the power of biology to deliver new medical therapies, means of recycling and environmentally-friendly food sources will be under the spotlight at Downing Street today (Wednesday 19 July) as science leaders and Ministers meet to unleash the full potential of the UK’s engineering biology sector.

19 Jul 2023

Berkeley Lab and Genentech Team Up to Develop Next-Generation Drug Delivery System

Many diseases can be successfully treated in the simple environment of a cell culture dish, but to successfully treat real people, the drug agent has to take a journey through the infinitely more complex environment within our bodies and arrive, intact, inside the affected cells.

18 Jul 2023

New P38 Inhibitors Selectively Target Cardiac Cell Death

The p38 protein regulates a wide variety of cellular functions and is related to diseases such as chronic inflammation, immunological disorders, or cancer.

14 Jul 2023

AI-Powered Collaboration Aims to Transform Drug Development

Critical Path Institute (C-Path), a leading global nonprofit committed to expediting drug development through the acceleration of regulatory-endorsed solutions, today announced a newly formalized Memorandum of Understanding (MOU) with Vivpro, an industry-leading provider of a revolutionary biointelligence software platform and innovative services.

14 Jul 2023

Drug Discovery & Pharmaceuticals

New Methods to Modify Molecular Structure Could Lead to More Tailored Drugs

Revolutionizing Drug Discovery: The Role of AI in Lead Optimization

Yeast-Based Method Could Accelerate Discovery of Plant-Based Medicinal Compounds

Scientists Develop Novel Glycoengineering Platform to Revolutionize Vaccine and Therapeutic Production

Pure Capped mRNA Vaccine Opens the Door to More Effective Vaccines with Lower Chances of Inflammation

Small Chemical Change to Boost Bioavailability of Drug Molecules

Targeted MicroRNA-34a Therapy Shows Promise in Slowing Tumor Growth in Mice

MAGE Technology Helps Reveal the Potency of Antibiotics

Waters Corporation and Princeton University Announce Multi-Year Research Collaboration

AI Tool Speeds Up Vaccine Development

New Breakthrough in Generative AI Models and AlphaFold Structures for Drug Discovery

New Collaboration Aims to Advance Cancer Therapies Against Previously Undruggable Targets

Analyzing the Possibility to Design Improved Vaccines

Researchers Design New Algorithm to Boost Pandemic Preparedness

Researchers Make Breakthrough in Fight Against Familial Hypercholesterolemia

New Vaccine Shows Promise in Combating MenB

Government Backing UK Engineering Biology Firms to Revolutionise Medicine, Food and Environmental Protection

Berkeley Lab and Genentech Team Up to Develop Next-Generation Drug Delivery System

New P38 Inhibitors Selectively Target Cardiac Cell Death

AI-Powered Collaboration Aims to Transform Drug Development

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Expert Insights: HiMedia Labs on Advancing Nucleic Acid Extraction Across Industries

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