Drug Discovery & Pharmaceuticals

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Strata Oncology publishes study validating integrative pan-solid tumor predictor of PD-1/PD-L1 blockade benefit

Strata Oncology, Inc., a next-generation precision oncology company enabling smarter and earlier cancer treatment, today announced the publication of a new peer-reviewed study validating the clinical utility of the company's proprietary pan-solid tumor predictive biomarker for anti-PD-1/PD-L1 checkpoint inhibitor monotherapy benefit, Immunotherapy Response Score (IRS).

8 Feb 2023

Novel combination therapy shows promise in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive form of cancer that originates in the bone marrow, rapidly spreads to the blood and can quickly cause death if not treated promptly.

8 Feb 2023

Gaining insights into human disease biology through CRISPR platforms

In this interview, we speak with Laralynne Przybyla about how she is utilizing CRISPR platforms to understand human disease biology in greater detail.

From Society for Laboratory Automation and Screening (SLAS) 7 Feb 2023

Antibody that blocks VEGF-B could be a potential therapeutic option for fatty liver disease

There is currently no drug for treating non-alcoholic fatty liver disease, which affects many people with type 2 diabetes and which can result in other serious liver diseases.

6 Feb 2023

New chemical reaction could transform drug production

Pharmaceutical synthesis is often quite complex; simplifications are needed to speed up the initial phase of drug development and lower the cost of generic production.

3 Feb 2023

Losartan prevents immunotherapy-related edema, improves survival in glioblastoma mouse models

Patients with glioblastoma-;the deadliest type of primary brain tumor-;may potentially benefit from immunotherapy medications called immune checkpoint inhibitors that stimulate an immune response against cancer cells.

3 Feb 2023

Clinically approved fungal vaccine protects against fungal infections

A new vaccine developed by the University of Georgia might be the first clinically approved immunization to safeguard against invasive fungal infections, which are becoming more common as antifungal drug resistance grows.

From University of Georgia 1 Feb 2023

Scientists develop new design principles to improve cancer vaccines

A new way to significantly increase the potency of almost any vaccine has been developed by researchers from the International Institute for Nanotechnology at Northwestern University.

1 Feb 2023

AI-based strategy helps discover high-affinity antibody drugs

Scientists at University of California San Diego School of Medicine have developed an artificial intelligence (AI)-based strategy for discovering high-affinity antibody drugs.

31 Jan 2023

A high-throughput drug discovery assay for the endoplasmic reticulum aminopeptidase 1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

31 Jan 2023

Massive clinical study on type 1 diabetes patients

A massive clinical study on an approved psoriasis drug is now underway. The drug will be tested on people who have just been diagnosed with type 1 diabetes. The drug, according to the theory, could preserve the patient’s remaining insulin production.

30 Jan 2023

Newly discovered enzyme tells specific molecules precisely how to arrange themselves

Just as a choreographer's notation tells a dancer to strike a particular pose, an enzyme newly discovered by Rice University scientists is able to tell specific molecules precisely how to arrange themselves, down to the angle of single hydrogen bonds.

30 Jan 2023

Scientists receive $10 million from HHMI for research on using viruses as therapeutic agents

Taking a bold step into a new era of biology, a team of scientists from the University of California San Diego, the J. Craig Venter Institute and Yale University has been awarded $10 million by the Howard Hughes Medical Institute to support research on using viruses as new therapeutic agents.

27 Jan 2023

Spikes protruding from red algae-derived metal-polysaccharide responsible for antimicrobial activities

Antibiotic resistant bacteria are becoming more and more of a concern as traditional sources of anti-microbial treatments become less effective.

27 Jan 2023

New spray can prevent infections and kill antibiotic-resistant bacteria

The World Health Organization ranks antibiotic resistance as one of the top ten threats to global health. There is therefore a great need for new solutions to tackle resistant bacteria and reduce the use of antibiotics.

27 Jan 2023

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases.

From Ubiquigent Limited 23 Jan 2023

Drug Discovery & Pharmaceuticals

Strata Oncology publishes study validating integrative pan-solid tumor predictor of PD-1/PD-L1 blockade benefit

Novel combination therapy shows promise in acute myeloid leukemia

Gaining insights into human disease biology through CRISPR platforms

Antibody that blocks VEGF-B could be a potential therapeutic option for fatty liver disease

New chemical reaction could transform drug production

Losartan prevents immunotherapy-related edema, improves survival in glioblastoma mouse models

Clinically approved fungal vaccine protects against fungal infections

Scientists develop new design principles to improve cancer vaccines

AI-based strategy helps discover high-affinity antibody drugs

A high-throughput drug discovery assay for the endoplasmic reticulum aminopeptidase 1

Massive clinical study on type 1 diabetes patients

Newly discovered enzyme tells specific molecules precisely how to arrange themselves

Scientists receive $10 million from HHMI for research on using viruses as therapeutic agents

Spikes protruding from red algae-derived metal-polysaccharide responsible for antimicrobial activities

New spray can prevent infections and kill antibiotic-resistant bacteria

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

New method to treat MRSA infections with penicillin-type drugs

Using fungi to transform ocean plastic waste into key pharmaceutical components

Intracellular drug delivery using a novel nano transporter

New solution to treat diseases caused by exaggerated inflammation

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

Commercializing Innovation in a Life Sciences Ecosystem

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