Genomics

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Newly discovered 'mutation fog' linked to normal DNA repair process

Hypermutation is an unusual occurence that can lead to many nearby mutations at once, severely damaging our genetic material and potentially causing cancer.

5 Aug 2020

New method reveals the dynamics of cell development and gene activity

Studies on cellular dynamics are vital to interpret the development of cells and the progression of various diseases.

5 Aug 2020

New study may offer a novel, potential target for treating breast cancer

According to researchers, G-quadruplexes have been demonstrated to play a crucial role in specific types of breast cancer for the first time.

5 Aug 2020

Study uncovers molecular mechanism of metabolite-mediated epigenome involved in organismal aging

Scientists have recently demonstrated that acetyl-CoA connects mitochondrial stress to the nuclear epigenome through the NuRD complex.

4 Aug 2020

Hudsonalpha researchers help elucidate functional elements of the genome

Although the Human Genome Project sequenced a nearly-complete human genome almost 20 years ago, only about two percent of the genes in the human genome have been extensively studied and identified as protein-coding genes. Proteins form the basis of living tissues and play a central role in biological processes.

3 Aug 2020

Genetic analysis helps determine causal relationships between diabetes, obesity and NAFLD

Diabetes, obesity and nonalcoholic fatty liver disease (NAFLD) are all common diseases that can lead to serious health implications.

3 Aug 2020

Ecological stress within freshwater species can be detected with DNA metabarcoding

DNA or eDNA, for example, river water or, as in the case of the study by the team from the University of Duisburg-Essen (Essen, Germany) within the German Barcode of Life project (GBOL II): Vera Zizka, Dr Martina Weiss and Prof Florian Leese, from individuals in bulk samples.

3 Aug 2020

Detailed 3D structure provides a roadmap for tweaking CRISPR-Cas9–guided base editors

Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy.

31 Jul 2020

Researchers use human genome database to study different types of cancer cells

David Gilbert from Florida State University is applying the latest data relating to the human genome to gain a deeper insight into cancer.

30 Jul 2020

New tool predicts and identifies novel genes involved in various biological processes

Chromatin plays a significant role in the silencing and activation of gene transcription, and establish the fate of the cells during development.

30 Jul 2020

Researchers create a new mouse model for studying glioblastoma

More than 200 genes with novel and known roles in glioblastoma - the most aggressive type of brain cancer - offer promising new drug targets.

30 Jul 2020

Scientists use computational biology to identify functional elements in the human genome

UMass Medical School researchers Zhiping Weng, PhD, and Jill Moore, PhD, and MD/PhD students Michael Purcaro and Henry Pratt are lead authors on the latest publication of data from the ambitious ENCODE project.

30 Jul 2020

Multiomics analysis reveals multiple characteristics of HIV-1-producing cells in vivo

For eradication of HIV-1 infection, it is important to elucidate the detailed features and heterogeneity of HIV-1-infected cells in vivo.

29 Jul 2020

Supercomputer analyses point to a new pathway for COVID-19 inflammatory response

Analyses of lung fluid cells from COVID-19 patients conducted on a supercomputer point to patterns that may explain the body's response to SARS-CoV-2.

29 Jul 2020

Scientists map the genome of aphid-like pest that decimates vineyards

Following a decade-long effort, scientists have mapped out the genome of an aphid-like pest capable of decimating vineyards. In so doing, they have discovered how it spreads -- and potentially how to stop it.

29 Jul 2020

Deep learning algorithm can infer molecular alterations in cancer from histology images

Researchers at the University of Chicago Medicine Comprehensive Cancer Center, working with colleagues in Europe, created a deep learning algorithm that can infer molecular alterations directly from routine histology images across multiple common tumor types.

29 Jul 2020

Biologists identify a molecular mechanism that underlies phenotypic plasticity

Evolutionary and developmental biologist Craig Albertson and colleagues at the University of Massachusetts Amherst report that they have identified a molecular mechanism that allows an organism to change the way it looks depending on the environment it is exposed to, a process known as phenotypic plasticity.

29 Jul 2020

Scientists discover evolutionary lineage of SARS-CoV-2 virus

By reconstructing the evolutionary history of SARS-CoV-2, the virus that is responsible for the COVID-19 pandemic, an international research team of Chinese, European and U.S. scientists has discovered that the lineage that gave rise to the virus has been circulating in bats for decades and likely includes other viruses with the ability to infect humans.

29 Jul 2020

Human genome may explain the neonatal origins of immune and inflammatory diseases

A study published in the journal Nature Communications has pinpointed a number of areas of the human genome that may help explain the neonatal origins of chronic immune and inflammatory diseases of later life, including type 1 diabetes, rheumatoid arthritis and coeliac disease.

29 Jul 2020

New technology helps visualize entire genome at molecular resolution

Scientists from Harvard University, CNAG, and CRG have demonstrated a pioneering technology that helps observe hundreds of genomes under the microscope.

29 Jul 2020

Genomics

Newly discovered 'mutation fog' linked to normal DNA repair process

New method reveals the dynamics of cell development and gene activity

New study may offer a novel, potential target for treating breast cancer

Study uncovers molecular mechanism of metabolite-mediated epigenome involved in organismal aging

Hudsonalpha researchers help elucidate functional elements of the genome

Genetic analysis helps determine causal relationships between diabetes, obesity and NAFLD

Ecological stress within freshwater species can be detected with DNA metabarcoding

Detailed 3D structure provides a roadmap for tweaking CRISPR-Cas9–guided base editors

Researchers use human genome database to study different types of cancer cells

New tool predicts and identifies novel genes involved in various biological processes

Researchers create a new mouse model for studying glioblastoma

Scientists use computational biology to identify functional elements in the human genome

Multiomics analysis reveals multiple characteristics of HIV-1-producing cells in vivo

Supercomputer analyses point to a new pathway for COVID-19 inflammatory response

Scientists map the genome of aphid-like pest that decimates vineyards

Deep learning algorithm can infer molecular alterations in cancer from histology images

Biologists identify a molecular mechanism that underlies phenotypic plasticity

Scientists discover evolutionary lineage of SARS-CoV-2 virus

Human genome may explain the neonatal origins of immune and inflammatory diseases

New technology helps visualize entire genome at molecular resolution

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