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Targeting Fat Metabolism Enhances Ferroptosis-Inducing Cancer Treatments

According to a study conducted by researchers at the Van Andel Institute, preventing cancer cells from obtaining fat may improve the efficacy of a particular cancer treatment.

23 Oct 2024

Unraveling the Genetic Blueprint of the Deep Brain

Researchers have discovered 254 genetic variations that influence important “deep brain” structures, such as those that govern memory, motor skills, addictive behaviors, and more, in one of the biggest-ever investigations of DNA and brain volume.

22 Oct 2024

How Cancer Cells Use Ribosomes to Evade the Immune System

The protein factories of our cells are much more diverse than we thought they were. Scientists from the Netherlands Cancer Institute have now shown that cancer cells can use these so-called ribosomes to boost their invisibility cloak, helping them hide from the immune system.

22 Oct 2024

Magnetic Control of Brain Cells: A Step Forward in Neuromodulation

The introduction of magnetogenetics provides a noninvasive technique to modulate brain circuits, paving the way for innovative therapies in neuromodulation.

18 Oct 2024

Yeast's Survival Strategy Provides Clues for Targeting Cancer Cells

The discovery of a surprising way yeast used to brew beer can survive starvation could open the door to new treatments for cancer.

17 Oct 2024

New Insights into Nager Syndrome Through Zebrafish Models

Nager syndrome, or NS, is a rare genetic disease that affects the development of the face and limbs, usually causing anomalies in the bone structures of the jaws, cheeks, and hands.

17 Oct 2024

Unveiling the Protective Role of KLF6 in Diabetic Kidney Disease

Research by Stony Brook Medicine nephrology specialists may help prevent or reduce diabetic kidney disease progression by targeting cellular signaling between kidney cells and inducing a specific gene.

11 Oct 2024

CAR-NKT Cells Show Promise in Overcoming Solid Tumor Barriers

Chimeric antigen receptor T-cell therapy (CAR-T) has shown significant promise in the treatment of blood malignancies in the fight against cancer.

8 Oct 2024

UNC Researchers Unveil CAR-NKT Therapy for Enhanced Antitumor Activity

In the fight against cancer, chimeric antigen receptor T cell (CAR-T) therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors.

8 Oct 2024

Uncovering the Genetic Drivers of Metastatic Prostate Cancer

Researchers at the University of Michigan Rogel Cancer Center have recently uncovered a novel subtype of aggressive prostate cancer.

7 Oct 2024

"Paralog Hopping" Uncovers New Binding Sites for Cancer Drugs

Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites.

4 Oct 2024

Discovering New Drug Targets Through Paralog Hopping

3 Oct 2024

New Insights into the Epigenetic Hallmarks of Cancer

Cancer mortality has just surpassed cardiovascular disease for the first time ever and one in two men, and one in three women, will be diagnosed with some form of the disease in the US, according to the NIH.

3 Oct 2024

Unlocking the Mysteries of Repeat Expansion in Genetics

Research led by scientists at Queen Mary University of London is heralding in a new era for genetic sequencing and testing.

3 Oct 2024

New AI Model ProteinGenerator Revolutionizes Protein Design with Sequence and Structure Integration

Harnessing deep learning, ProteinGenerator designs diverse proteins with specific properties, offering new avenues for drug development and biotechnology.

2 Oct 2024

Bipolar Disorder and Epilepsy Share Genetic Roots

A team of researchers from the Chinese Academy of Sciences has uncovered compelling evidence of a genetic link between bipolar disorder type I (BD-I) and epilepsy, potentially revolutionizing our understanding of these complex neuropsychiatric conditions.

1 Oct 2024

Two Alzheimer’s Genetic Risk Factors Trigger Harmful Inflammation in Females

Weill Cornell Medicine investigators have found that two genetic variants that confer high risk of Alzheimer's disease (AD) together trigger a harmful inflammatory response in the brain's immune cells, particularly in females, in a preclinical model.

1 Oct 2024

Huntington's Disease Protein Disrupts DNA Repair

Researchers at McMaster University have found that the mutated protein in Huntington's disease patients disrupts DNA repair as it should, which affects the capacity of brain cells to regenerate.

30 Sep 2024

Motor And Extracellular Matrix Proteins Play A Critical Role In Cleft Palate Formation

The study reveals 44 differentially expressed proteins in cleft palate models, shedding light on molecular mechanisms and potential prenatal diagnostic markers.

30 Sep 2024

Comprehensive multi-omics approach reveals detailed insights into diabetes mechanisms

In a recent study published in Nature Communications, researchers utilized a comprehensive multi-omics approach, integrating genomic, proteomic, and metabolomic data from a diverse cohort, to uncover detailed molecular interactions and identify distinct diabetes subgroups.

20 Sep 2024