Molecular & Structural Biology

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DNA Repair Breakthrough: Scientists Reveal RecA's Precise Helix Navigation

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling single-strand end into intact double strands, and repairing the break based on the undamaged sequence.

22 Jan 2024

Study Uncovers Chromatin Modifier-Centered Pathway for Grain Size Regulation in Rice

Chromatin is the complex of DNA and proteins that makes up the genetic material in the nucleus of eukaryotic cells.

18 Jan 2024

Universal Networking Principles Wire Up Different Brains

A new study by physicists and neuroscientists from the University of Chicago, Harvard and Yale describes how connectivity among neurons comes about through general principles of networking and self-organization, rather than the biological features of an individual organism.

18 Jan 2024

Investigating the Functional Mechanisms of RNA Replicase

It has long been a mystery how the complex molecular machinery of life sprang from modest beginnings.

17 Jan 2024

Herts Awarded Its Biggest Ever Research Grant to Develop Biodetection Technologies Against Harmful, Airborne Pathogens

The University of Hertfordshire has been awarded £13.5million – its biggest ever research grant – to expand and progress its sector-leading, research-led development of biodetection technologies against harmful, airborne pathogens.

17 Jan 2024

Uncovering the Role of Faulty Signalling in Immune Cell Development

An autoimmune disease occurs when the body’s own cells are attacked by the immune system in addition to external pathogens.

16 Jan 2024

Epigenetic Key Unlocks Treatment Path for Endocrine-Resistant Breast Cancer

Endocrine resistance – a major cause of breast cancer deaths – can be underpinned by an epigenetic change called DNA methylation, researchers at the Garvan Institute of Medical Research have discovered.

10 Jan 2024

Exploring the Dual Role of Phosphorylated α-Synuclein in Healthy Neural Function

It has been found by researchers that phosphorylated α-synuclein, a protein linked to a number of neurodegenerative illnesses, including Parkinson's disease and Lewy body dementia, is also engaged in the regular processes of neuronal communication in a healthy brain.

10 Jan 2024

Key Cytokine Pairs Driving Sepsis Damage Identified

One of the main causes of death in the ICU is sepsis, which is the result of an infection that causes the immune system to mistakenly target the body.

9 Jan 2024

Computational Creation of Complex Protein All-α Structures

Based on their amino acid sequences, proteins fold into distinct three-dimensional structures that determine their function. While de novo protein design has advanced significantly, complex all-αproteins, in which α-helices are not stacked in a parallel fashion within three-dimensional structures, have not been as easily designed.

8 Jan 2024

B12-Producing Gut Bacteria Modulate Neurotransmitter Levels and Reduce Seizures in C. elegans

A new study published in Nature Cell Biology by Mark Alkema, PhD, professor of neurobiology, establishes an important molecular link between specific B12-producing bacteria in the gut of the roundworm C. elegans and the production of acetylcholine, a neurotransmitter important to memory and cognitive function.

5 Jan 2024

A Pair of Force-Activated Gene Regulating Proteins Guide Fetal Bone Development

A pair of proteins, YAP and TAZ, has been identified as conductors of bone development in the womb and could provide insight into genetic diseases such as osteogenesis imperfecta, known commonly as "brittle bone disease."

5 Jan 2024

New Method Designs Proteins With Complex Shapes

A team of researchers has developed an innovative method to design complicated all-α proteins, characterized by their non-uniformly arranged α-helices as seen in hemoglobin.

5 Jan 2024

A Dihydrofolate Reductase Single-Domain Protein Catenane

Professor Wen-Bin Zhang of the College of Chemistry and Molecular Engineering at Peking University and the Beijing Academy of Artificial Intelligence, along with Dr. Jing Fang of the same institution, are leading the study.

2 Jan 2024

Novel Solution Revolutionizes Enzyme Production

The increasing need to switch to more environmentally friendly industrial processes is driving up demand for industrial enzymes.

2 Jan 2024

EPFL Scientists Develop Platform for Orally Available Cyclic Peptide Drugs

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy.

29 Dec 2023

Groundbreaking Insights Into How Typical Perfluoroalkyl Acids Accelerate DNA Degradation

Recent research published in the journal Eco-Environment & Health (Volume 2, 2023) reveals groundbreaking insights into how typical PFAAs accelerate the degradation of DNA.

26 Dec 2023

Fox Urine Compound Activates Multiple Sensory Pathways for Robust Insect Avoidance

Crop damage in agriculture and the transmission of vector-borne diseases by insect pests have become worldwide threat nowadays.

26 Dec 2023

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

26 Dec 2023

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

26 Dec 2023

Molecular & Structural Biology

DNA Repair Breakthrough: Scientists Reveal RecA's Precise Helix Navigation

Study Uncovers Chromatin Modifier-Centered Pathway for Grain Size Regulation in Rice

Universal Networking Principles Wire Up Different Brains

Investigating the Functional Mechanisms of RNA Replicase

Herts Awarded Its Biggest Ever Research Grant to Develop Biodetection Technologies Against Harmful, Airborne Pathogens

Uncovering the Role of Faulty Signalling in Immune Cell Development

Epigenetic Key Unlocks Treatment Path for Endocrine-Resistant Breast Cancer

Exploring the Dual Role of Phosphorylated α-Synuclein in Healthy Neural Function

Key Cytokine Pairs Driving Sepsis Damage Identified

Computational Creation of Complex Protein All-α Structures

B12-Producing Gut Bacteria Modulate Neurotransmitter Levels and Reduce Seizures in C. elegans

A Pair of Force-Activated Gene Regulating Proteins Guide Fetal Bone Development

New Method Designs Proteins With Complex Shapes

A Dihydrofolate Reductase Single-Domain Protein Catenane

Novel Solution Revolutionizes Enzyme Production

EPFL Scientists Develop Platform for Orally Available Cyclic Peptide Drugs

Groundbreaking Insights Into How Typical Perfluoroalkyl Acids Accelerate DNA Degradation

Fox Urine Compound Activates Multiple Sensory Pathways for Robust Insect Avoidance

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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