Overview
A quickly maturing, persistent, and scalable isogenic system to learn frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
ioGlutamatergic Neurons TDP-43M337V are opti-ox™ precision reprogrammed glutamatergic neurons carrying a genetically engineered M337V mutation in the TARDBP gene, encoding TAR DNA binding protein 43 (TDP-43), available with either a heterozygous (M337V/WT) or homozygous (M337V/M337V) genotype.
Human stem cells, within days, transform constantly into mature, functional glutamatergic neurons that tend to express pan-neuronal and glutamatergic markers MAP2, TUBB3, and VGLUT2, as well as disease-relevant TARDBP.
Wild-type ioGlutamatergic Neurons™ form the genetically paired control for the ioGlutamatergic Neurons TDP-43M337V disease model. This physiologically-appropriate isogenic pairing provides a user-friendliness and quick next-generation model to examine the effect of mutant TDP-43 protein on disease advancement.
Features
Make true comparisons
Users can pair the ioDisease Model Cells with the genetically matched wild-type ioGlutamatergic Neurons to analyze the effect of the mutation on disease advancement.
Scalable
The cells are accessible in industrial scale numbers with industry-leading seeding densities and at a price range that enables them to be used for everything from research to high throughput screening.
Quick
The disease model cells and isogenic control cells are ready for experimentation as soon as two days after revival and establish structural neuronal networks by 11 days.
Applications
- FTD and ALS research
- High-throughput screening
- Drug discovery and development
- Disease modeling
- Co-culture studies
- Electrophysiological assays (MEA)