Overview
The availability of a quickly maturing, constant, and scalable isogenic system enables learning about frontotemporal dementia (FTD).
ioGlutamatergic Neurons MAPTP301S/WT is known as opti-ox™ precision reprogrammed glutamatergic neurons consisting of a genetically engineered heterozygous P301S mutation in the MAPT gene that is encoding the tau protein.
Also, disease model cells with the MAPT mutation come with a heterozygous N279K mutation (cat no. io1009) and a homozygous P301S mutation (cat no. io1008).
Features
Make true comparisons
It is also possible to pair the ioDisease Model Cells with the genetically matched wild-type ioGlutamatergic Neurons to instantly examine the effect of mutant tau protein on disease.
Scalable
Industrial scale quantities come with industry-leading seeding densities, and at a price point enabling the cells to be utilized for research to high throughput screening.
Quick
The disease model cells and isogenic control are all set as early as two days post revival, and develop structural neuronal networks at 11 days.
Applications
- FTD research
- Drug discovery and development
- Disease modeling
- Electrophysiological assays (MEA)
- Co-culture studies