ioGlutamatergic Neurons MAPT N279K/WT™


A quickly maturing, constant, and scalable isogenic system to learn about frontotemporal dementia (FTD).

ioGlutamatergic Neurons MAPTN279K/WT is known to be opti-ox™ precision reprogrammed glutamatergic neurons consisting of a genetically engineered heterozygous N279K mutation present in the MAPT gene encoding the tau protein.

Also, disease model cells with the MAPT mutation come with a homozygous (cat no. io1008) and a heterozygous (cat no. io1015) P301S mutation.


Make true comparisons

Users can pair the ioDisease Model Cells with the genetically matched wild-type ioGlutamatergic Neurons to directly examine the effect of mutant tau protein on disease.


Industrial scale quantities come with first-in-class seeding densities, and at a price point that enables the cells to be utilized from research to high throughput screening.


The disease model cells and isogenic control are all set for the experiment as early as two days post revival, and develop structural neuronal networks at 11 days.


  • FTD research
  • Drug discovery and development
  • Disease modeling
  • Electrophysiological assays (MEA)
  • Co-culture studies

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