ioGlutamatergic Neurons HTT 50CAG/WT™


A quickly maturing, constant, and scalable isogenic system to study Huntington’s disease.

ioGlutamatergic Neurons HTT50CAG/WT are known as opti-ox™ precision reprogrammed glutamatergic neurons consisting of a genetically engineered heterozygous 50 CAG trinucleotide repeat expansion in exon 1 of the HTT gene.

In just a matter of days, human stem cells tend to transform constantly into mature, functional glutamatergic neurons that tend to express pan-neuronal and glutamatergic markers TUBB3, MAP2, and VGLUT2 by day 11, as well as the disease-relevant Huntingtin protein.’s wild type ioGlutamatergic Neurons™ develop the genetically matched control for the ioGlutamatergic Neurons HTT50CAG/WT disease model. This physiologically-relevant isogenic pairing provides a quick and user-friendly next-generation model to examine the impact of gene function on disease progression.



Cells are programmed in a way to mature rapidly upon revival with the help of a simple two-phase protocol using an open-sourced medium.


Industrial scale quantities come with industry-leading seeding densities, and at a price point enabling the cells to be utilized from research to high throughput screening.

Make true comparisons

Users can be confident in their data. ioDisease Model Cells could be coupled with ioWild Type Cells to offer a genetically matched, highly characterized background for the accurate examination of gene function.


  • Basic research
  • Disease modeling
  • Drug discovery
  • Electrophysiological assays (MEA)
  • Co-culture studies

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