ioGlutamatergic Neurons MAPT P301S/P301S™


A quickly maturing, steady, and scalable isogenic system to learn about frontotemporal dementia (FTD).

ioGlutamatergic Neurons MAPTP301S/P301S are known to be opti-ox™ precision reprogrammed glutamatergic neurons consisting of a genetically engineered homozygous P301S mutation present in the MAPT gene encoding the tau protein.

Furthermore, disease model cells with the MAPT mutation are available with a heterozygous N279K mutation (cat no. io1009) and heterozygous P301S mutation (cat no. io1015).


Make true comparisons

Users can pair the ioDisease Model Cells along with the genetically matched wild-type ioGlutamatergic Neurons to instantly analyze the effect of mutant tau protein on disease.


Industrial scale quantities come with best-in-industry seeding densities, and at a price point enabling the cells to be utilized from research to high throughput screening.


The isogenic control and disease model cells are all set for the experiment ready as early as 2 days post revival, and develop structural neuronal networks at 11 days.


  • FTD research
  • Disease modeling
  • Drug discovery and development
  • Electrophysiological assays (MEA)
  • Co-culture studies

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