Immune system–related differences in dialysis, kidney transplant patients are amplified by SARS-CoV-2

People with kidney failure who are on dialysis or who have received a kidney transplant face a higher risk of dying from COVID-19. New research reveals that these individuals have profound immune system–related differences compared with people with normal kidney function, and that these differences are further amplified by SARS-CoV-2 infection. The findings will be presented online at ASN Kidney Week 2021 November 4–November 7.

The study included 32 patients who were on hemodialysis or who received a kidney transplant and were hospitalized for COVID-19, as well as 12 dialysis or transplant patients without COVID-19 and 10 healthy controls.

Patients with a severe COVID-19 course were older and showed lower counts of immune cells called lymphocytes and monocytes, compared with patients with a benign disease course. Patients without COVID-19 had lower numbers of all major immune cell subsets compared with healthy patients, and these numbers were further reduced in patients with COVID-19, especially in patients with a severe disease course.

Investigators noted several other immune system–related differences between patients and controls.

Although dialysis and kidney transplant patients are inherently heterogeneous groups, the immunological abnormalities during COVID-19 are similar across the two cohorts, with the exception of more pronounced defects in innate immunity and a dampened antibody response in kidney transplant patients."

Stefania Affatato, Lead Author, Università di Brescia – ASST Spedali Civili di Brescia, Brescia, Italy

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of AZoLifeSciences.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Synthetic Anti-Clotting Agent Derived from Bloodsucking Organisms Saliva