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Researchers develop new molecular workflow to study single-cell genomics of diseases

Although advances in genetics and genomics reveal numerous disease-associated gene mutations, physicians and researchers still wrestle with the tricky challenge of linking those mutations to actual disease-causing processes.

23 Apr 2020

Study shows how tumor cells respond to nutrient deficiency

Some solid tumors have a very high growth rate, which often leads to a lack of vascularization due to the impossibility to develop, at the same time, the blood vessels that accompany and nourish it.

22 Apr 2020

New study could lead to effective immunotherapy treatments for cancer patients

According to a study recently published in the eLife journal, researchers have devised a new method to chart the molecules present on tumor cells that indicate their presence to the immune system.

22 Apr 2020

A ‘virtual embryo’ for unprecedented single-cell studies

Researchers from EMBL Heidelberg and from the University of Padua School of Medicine have created the first complete description of early embryo development, accounting for every single cell in the embryo.

21 Apr 2020

Researchers use genome-wide CRISPR technology to identify leukemia's weakness

A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia, a type of cancer that remains difficult to treat and is marked by frequent relapse.

From UC San Diego 21 Apr 2020

Study reveals the formation of tuft cells and their role in immunity

Chronic pancreatitis, or persistent inflammation of the pancreas, is a known risk factor that leads to the development of pancreatic cancer, which is the third-deadliest cancer in the United States.

20 Apr 2020

Chemical tools can regulate lipid concentration in living cells

Lipids have several crucial functions in the human body: They serve as messengers, which mediate the growth of cells and regulate the release of hormones.

20 Apr 2020

Study pinpoints a key brain region for controlling binge drinking

A team of National Institutes of Health-funded researchers at the Medical University of South Carolina has found that deactivating a stress-signaling system in a brain area known for motivation and emotion-related behaviors decreases binge drinking.

20 Apr 2020

Autoimmunity Plays A Role In Parkinson's Disease

A new study co-led by scientists at the La Jolla Institute for Immunology (LJI) adds increasing evidence that Parkinson's disease is partly an autoimmune disease.

20 Apr 2020

Cancer Drug Resistance Study Raises Immune Red Flags

Sooner or later, most cancer patients develop resistance to chemotherapy drugs designed to kill their cancer, forcing oncologists to seek alternatives.

20 Apr 2020

Gene Variant Staves Off Alzheimer's In Some People

People with a gene that puts them at risk for Alzheimer's disease are protected from its debilitating effects if they also carry a variant of a different gene.

17 Apr 2020

Experience Matters For Immune Cells

The discovery that immune T cells have a spectrum of responsiveness could shed light on how our immune system responds to infections and cancer.

17 Apr 2020

Deadliest Malaria Strain Protects Itself From The Immune System

The parasite causing the most severe form of human malaria uses proteins to make red blood cells sticky, making it harder for the immune system to destroy it.

17 Apr 2020

Diagnostics, Meet CRISPR

The simplicity of urine sampling has been combined with the excellent sensing abilities of CRISPR to improve diagnostic testing for kidney transplant patients.

17 Apr 2020

New optical imaging technology makes fluorescence microscopy more efficient

Scientists have been using fluorescence microscopy to study the inner workings of biological cells and organisms for decades.

16 Apr 2020

Single-cell cloning can lead to new therapies for COPD

Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death around the world. Now, two internationally acclaimed stem cell experts have discovered a large number of abnormal stem cells found in the lungs of COPD patients.

16 Apr 2020

Improving drug targets for asthma and rheumatoid arthritis

Researchers have found that immune T cells exhibit a range of responsiveness. This finding could offer insights into how the immune system of humans responds to infections and cancer, and what goes wrong in immune diseases.

16 Apr 2020

How human cells recognize undesirable guests

Until now, the immune sensor TLR8 has remained in the shadows of science. A research team led by the University of Bonn has now discovered how this sensor plays an important role in defending human cells against intruders.

15 Apr 2020

Metals can affect the formation of harmful misfolded peptide clusters in various diseases

Revealing the interactions between metal ions and peptides in the body could help develop enhanced treatments for Alzheimer’s diabetes, and other diseases.

14 Apr 2020

Important genetic mechanism behind inflammatory bowel disease revealed

Researchers at Children's Hospital of Philadelphia have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease.

10 Apr 2020