Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

New Metabolic Map Reveals How Blood Stem Cells Age and Become Diseased

Researchers from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and ETH Zürich have created the first integrated map detailing the metabolic and molecular changes in human blood stem cells as they age, specialize, or turn cancerous.

16 Jul 2025

MiROM Uses Infrared Light to Detect Protein Changes in Single Cells

MiROM identifies proteins by using mid-infrared light to detect molecular vibrations – essentially the natural "dance" of molecules within protein structures.

16 Jul 2025

Microglia Replacement Halts Progression of Fatal Neurological Disease in Mice and Humans

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive neurological disease with an average age of onset of 43 years and an average life expectancy of only 3 to 5 years after symptoms begin.

11 Jul 2025

Gene Editing Using CRISPR and AAV6 Impacts Long-Term Regeneration of Blood Stem Cells

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and senescence-like responses in blood stem cells, compromising their long-term ability to regenerate the blood system.

4 Jun 2025

New Genomic Score Predicts Risk of Progression in Multiple Myeloma

A new risk assessment score developed by researchers at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard reveals how multiple myeloma, a form of blood cancer, begins and progresses from precancerous to malignant states by tracing DNA mutations.

24 May 2025

3D Printing Collagen Scaffolds with Perfusable Systems for Tissue Engineering

Scientists have developed high-resolution 3D-printed collagen scaffolds with internal perfusion systems, enabling complex, vascularized tissue models that support cell viability, growth, and insulin secretion

6 May 2025

New Drug Combo Shows Promise Against Aggressive Leukemia in Landmark Study

A novel drug combination targeting LSD1 and GSK3 shows promise in treating acute myeloid leukemia by promoting cell differentiation and reducing tumor growth.

28 Apr 2025

Rapid Growth of Blood Cancer Driven by a Single Genetic ‘HIT’

A new study has unveiled when chronic myeloid leukaemia, a type of cancer that affects the blood and bone marrow, arises in life and how fast it grows.

10 Apr 2025

DNA Aptamers Offer Precision Attack Against Leukemia Stem Cells

Drug-carrying DNA aptamers can deliver a one-two punch to leukemia by precisely targeting the elusive cancer stem cells that seed cancer relapses, researchers at the University of Illinois Urbana-Champaign report.

4 Apr 2025

Study Finds Key Mechanism Behind Plasma Cell Migration for Lasting Immunity

Vaccine effectiveness relies on creating a strong antibody response that can be reactivated to fight future infections.

13 Mar 2025

Macrophages Use Bacterial Debris To Fine-Tune Immune Responses

Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies for infections and inflammation.

6 Mar 2025

Dysfunctional Memory B Cells Identified as Key Cancer Therapy Target

University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood – known as the tertiary lymphoid structure – where they become frustratingly dysfunctional when in close contact with tumors.

20 Feb 2025

New CRISPR Tool Reveals Key Lymphoma Genes

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

7 Feb 2025

Inflammasome Helps Block Malignancy in Blood Stem Cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

Unveiling the Epigenetic Landscape of Blood Cancers

In recent years, biomedical laboratory research has undergone tremendous change, to the extent that computers have frequently replaced test tubes.

27 Nov 2024

3D Tumor Microenvironment Model Highlights Role of Ischemia and Acidification in Cancer Spread

Developed 3MIC model simulates tumor microenvironments, enabling direct observation of ischemic effects on cancer cell invasiveness and drug resistance.

4 Nov 2024

Understanding the Dynamics of Stem Cells

Age influences stem cell survival and immune diversity, according to new research on the long-term dynamics of transplanted stem cells in a patient’s body.

1 Nov 2024

Study Links Extracellular Vesicles to Blood Vessel Damage in Cancer

A landmark study led by WEHI and La Trobe University has found a potential new diagnostic marker that could be used to better detect the level of tissue damage in our bodies.

29 Oct 2024

Key Regulator of Heart Repair

UCLA researchers identified the protein GPNMB as a key regulator in the heart’s healing process following a heart attack.

28 Oct 2024

Study Uncovers Mechanism Behind B-Cell Maturation in Leukemia

Over four hundred people, 80% of them being children under 14 years old, will be diagnosed with B-cell Acute Lymphoblastic Leukaemia (B-ALL) next year in Spain, according to the latest projections from the Spanish network of cancer registries (REDECAN).

23 Oct 2024