Molecule News and Research

RSS

A missing link explains how class I molecules evolved from a class II-like origin Major Histocompatibility...

Which came first, MHC class I or MHC class II? For decades, it has been debated which of these two similar classes came first in evolution. Now, Keiichiro Hashimoto and his group at Fujita Health University, Japan, in collaboration with European research groups, have provided an answer to this question in a new article in PNAS.

14 Dec 2021

Study illustrates the concept of cool microscopy

Fluorescence light microscopy has the unique ability to observe cellular processes over a scale that bridges four orders of magnitude. Yet, its application to living cells is fundamentally limited by the very rapid and unceasing movement of molecules that define its living state.

From The Max Planck Institute 14 Dec 2021

Study finding helps better comprehend necroptosis for treating diseases

A group of scientists from WEHI, for the first time, visualized a human cell death complex associated with autoimmune and inflammatory conditions.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 14 Dec 2021

Why is Innovation Critical to Life Sciences Research?

In this interview, we speak to Kirstie Speck from Abcam about the importance of innovation within the life sciences and how its role will change over the next 10 years.

From Abcam 13 Dec 2021

First molecular structure of TDP-43 could pave the way for new ALS therapies

Scientists have determined for the first time the structure of the molecule associated with amyotrophic lateral sclerosis (ALS) and multiple other neurodegenerative diseases.

9 Dec 2021

Single-cell spatial analysis may provide information about neoadjuvant therapy for triple-negative breast cancer

A next-generation technology that allows the study of protein expression at the single-cell level and the location of the cells within the tumor microenvironment (TME) was feasible and provided information on the benefit of adding the immune checkpoint inhibitor atezolizumab (Tecentriq) to chemotherapy as neoadjuvant treatment for patients with early high-risk and locally advanced triple negative breast cancer (TNBC), according to results presented at the San Antonio Breast Cancer Symposium, held December 7-10, 2021.

8 Dec 2021

World's first metal-organic framework antibody-drug delivery system developed

It sounds like the stuff of science fiction: a man-made crystal that can be attached to antibodies and then supercharge them with potent drugs or imaging agents that can seek out diseased cells with the highest precision, resulting in fewer adverse effects for the patient.

8 Dec 2021

New strategy to improve the therapeutic efficacy of liver cancer immunotherapy

In recent years, tumor immunotherapy has emerged as a highly promising and much-touted oncological approach.

8 Dec 2021

Cancer drug effective against Alzheimer’s disease, says research

According to recent research carried out by researchers from the Weill Cornell Medicine, a gene mutation associated with Alzheimer’s disease changes a signaling pathway in specific immune cells of individuals with the disease.

7 Dec 2021

New nanoparticle adjuvant could lead to more powerful vaccines

A common strategy to make vaccines more powerful is to deliver them along with an adjuvant -; a compound that stimulates the immune system to produce a stronger response.

6 Dec 2021

Creating a Biological Clock in a Test Tube

We speak to researchers from the UC San Diego Center for Circadian Biology about their latest research that led to the development of a biological clock in a test tube.

From UC San Diego 6 Dec 2021

Biologists discover how a pathogenic fungus can bypass the immune system of plants

A team of biologists has identified that the pathogenic fungus Verticillium dahliae, responsible for wilt disease in many crops, secretes an 'effector' molecule to target the microbiome of plants to promote infection.

3 Dec 2021

New microchip to grow DNA strands could provide high-density 3D archival data storage

Researchers have made significant advances toward the goal of a new microchip able to grow DNA strands that could provide high-density 3D archival data storage at ultra-low cost – and be able to hold that information for hundreds of years.

2 Dec 2021

Study finds amphipathic peptide that safely opens endosomal membrane

The cell plasma membrane and the derived endosomal membranes are both greasy barriers that prevent the inflow of water-soluble macromolecules like nucleic acids and proteins into cells.

2 Dec 2021

New study shows how neuroblastoma cells deal with rapid division

The cells of a certain tumor type, called neuroblastoma, divide very rapidly. This rapid division can have potentially fatal consequences for them. A new study shows how neuroblastoma cells deal with this dilemma.

1 Dec 2021

Artificial nanopores enable single molecule-sorting of genetic material

Scientists from Japan recently designed the first bottom-up designed peptides that can develop into artificial nanopores to pinpoint.

25 Nov 2021

Novel therapeutic approach forces cancer cells to dormancy, prevents metastasis

A novel therapeutic approach inhibits the growth of metastatic tumors in mice by coercing cancer cells into a dormant state—where they cannot proliferate.

25 Nov 2021

Experts analyze key protein complexes involved in DNA replication and repair

Cryogenic electron microscopy (cryo-EM) allows scientists to investigate the assembly of DNA replication machinery where DNA is damaged.

25 Nov 2021

Viral RNA undergoes conformational changes to hijack host cells, says study

Scientists from the University of Colorado Anschutz Medical Campus recently identified how an RNA molecule from a virus develops a complex, three-dimensional structure, and is capable of changing its shape to hijack host proteins.

25 Nov 2021

UD biochemist explores how mRNA eraser enzymes work in our cells

University of Delaware biochemist Jeff Mugridge is trying to figure out how so-called mRNA eraser enzymes work in our cells, why those erasers can sometimes misbehave and lead to cancer, and how science can pave the way for possible solutions to this problem.

25 Nov 2021