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Scientists Develop AI-Powered Tool to Optimize Gene Delivery

Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient.

9 Aug 2024

Research Unlocks Secrets of Stem Cell Retention in Bone Marrow

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells. The findings, made in mice, were published today in the journal Science.

9 Aug 2024

New Findings Shed Light on ATM Activation in DNA Repair

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

9 Aug 2024

New Microscope Peels Back Layers of Cellular Mystery

What does the inside of a cell really look like? In the past, standard microscopes were limited in how well they could answer this question. Now, researchers from the Universities of Göttingen and Oxford, in collaboration with the University Medical Center Göttingen (UMG), have succeeded in developing a microscope with resolutions better than five nanometers (five billionths of a meter). This is roughly equivalent to the width of a hair split into 10,000 strands. Their new method was published in Nature Photonics.

9 Aug 2024

LINE-1 RNA from Ancient Viruses Promotes Bone Repair

Around half of the human genome is composed of DNA fragments originating from ancient viruses. These "transposable elements" (TEs) are now known to play various roles in modulating gene expression and disease development.

8 Aug 2024

UCL Scientists Uncover New Role of Ribosomes in Protein Folding

Scientists at UCL have discovered a novel role played by ribosomes during the folding of new proteins in cells, described in their paper in Nature.

8 Aug 2024

Researchers Uncover Method to Boost Stem Cell Production Using Interferon Gamma

Researchers at the Centre for Genomic Regulation (CRG) have discovered a treatment which accelerates the production and quality of pluripotent stem cells in mice.

8 Aug 2024

Detailed Analysis of Cucumber Centromeres Uncovers Key DNA Sequences and Retrotransposons

Centromeres are crucial for chromosome segregation during cell division and consist of repetitive DNA sequences.

8 Aug 2024

Single-Cell Analysis Uncovers Impact of TREM2 Mutation on Beta-Amyloid Plaques

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer's disease.

8 Aug 2024

High-Resolution Spatial Transcriptomics at Lower Cost

A novel spatial transcriptomics method that could revolutionize tissue sample gene expression profiling.

7 Aug 2024

Mini-Gut Model Unlocks Secrets of COVID-19 Diarrhea

Researchers at Johns Hopkins Medicine claim to have identified multiple molecular pathways linked to diarrhea caused by COVID-19, offering possible therapeutic interventions utilizing human stem cells to create a sort of “mini intestine-in-a-dish.

7 Aug 2024

Study Explores the Role of Sex-Biased Gene Expression in Autism Risk During Prenatal Development

The cortex of prenatal donors to determine differentially expressed genes based on sex and potentially identify molecular and cellular mechanisms that contribute to ASD.

7 Aug 2024

Lipid Nanoparticle-Encapsulated miR-193a-3p Mimic INT-1B3 Boosts Anti-Tumor Immunity

A new research paper was published in Oncotarget's Volume 15 on July 12, 2024, entitled, "INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death."

6 Aug 2024

The Importance of Antioxidant Therapy in Preventing Parkinson's Disease

The neurodegenerative condition known as Parkinson's disease is caused by the death of neurons that generate dopamine, a neurotransmitter essential for both motor control and cognitive function.

6 Aug 2024

Unveiling the Roots of Deadly Infant Leukemia

Researchers at the Josep Carreras Leukaemia Research Institute have identified the genetic foundation for newborn B-cell Acute Lymphoblastic Leukaemia (B-ALL) glucocorticoid resistance through MLL gene rearrangements.

6 Aug 2024

Discovery of Novel Macrophage Population Offers Hope for Lung Repair Post-Viral Infection

Researchers at the University of Liège (Belgium) have discovered a new population of macrophages, important innate immune cells that populate the lungs after injury caused by respiratory viruses.

5 Aug 2024

Mast Cells Recruit Neutrophils in Immune Response

Mast cells are well-known for their part in allergic reactions, but the immune system relies heavily on them. They release chemicals in response to allergens, which cause common allergy symptoms like tissue swelling and inflammation.

5 Aug 2024

Megamonas Bacteria Identified as Potential Obesity Culprit

A recent study from Cell Host & Microbe identifies Megamonas as a possible bacteria linked to obesity based on a large-scale cohort of obese Chinese people. This study demonstrates how the bacterium increases lipid absorption, breaks down intestinal myo-inositol, and causes obesity, which may lead to future approaches for managing obesity.

5 Aug 2024

Researchers Uncover How Phage Infection Dynamics Affect Viral Entry at Single-Cell Level

The process by which phages-;viruses that infect and replicate within bacteria-;enter cells has been studied for over 50 years.

5 Aug 2024

Breakthrough Method Captures Aging Impact on Alzheimer’s Disease in Lab-Grown Neurons

Researchers at Washington University School of Medicine in St. Louis have developed a way to capture the effects of aging in the development of Alzheimer's disease.

2 Aug 2024

Cell News and Research

Scientists Develop AI-Powered Tool to Optimize Gene Delivery

Research Unlocks Secrets of Stem Cell Retention in Bone Marrow

New Findings Shed Light on ATM Activation in DNA Repair

New Microscope Peels Back Layers of Cellular Mystery

LINE-1 RNA from Ancient Viruses Promotes Bone Repair

UCL Scientists Uncover New Role of Ribosomes in Protein Folding

Researchers Uncover Method to Boost Stem Cell Production Using Interferon Gamma

Detailed Analysis of Cucumber Centromeres Uncovers Key DNA Sequences and Retrotransposons

Single-Cell Analysis Uncovers Impact of TREM2 Mutation on Beta-Amyloid Plaques

High-Resolution Spatial Transcriptomics at Lower Cost

Mini-Gut Model Unlocks Secrets of COVID-19 Diarrhea

Study Explores the Role of Sex-Biased Gene Expression in Autism Risk During Prenatal Development

Lipid Nanoparticle-Encapsulated miR-193a-3p Mimic INT-1B3 Boosts Anti-Tumor Immunity

The Importance of Antioxidant Therapy in Preventing Parkinson's Disease

Unveiling the Roots of Deadly Infant Leukemia

Discovery of Novel Macrophage Population Offers Hope for Lung Repair Post-Viral Infection

Mast Cells Recruit Neutrophils in Immune Response

Megamonas Bacteria Identified as Potential Obesity Culprit

Researchers Uncover How Phage Infection Dynamics Affect Viral Entry at Single-Cell Level

Breakthrough Method Captures Aging Impact on Alzheimer’s Disease in Lab-Grown Neurons

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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