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Already characterized active substances exhibit unexpected effects

Every innovative drug starts with the search for an active substance targeting key players in disease-related processes.

23 Jul 2021

New study uncovers how enterococcal cytolysins affect cells

Although Enterococcus faecalis is usually an innocuous member of the bacterial community in the human gut, it can also cause several infections, including liver disorders. The bacteria produce cytolysins, which are molecules that destroy cells. In a new study, researchers have uncovered how they do so.

22 Jul 2021

Researchers discover nucleotide sequences characteristic of microRNA isoforms

Researchers from HSE University have discovered nucleotide sequences characteristic of microRNA isoforms (microRNAs with errors).

22 Jul 2021

Study identifies many small molecules that bind to certain areas of the SARS-CoV-2 genome

Scientists at Goethe University have now identified some regions of the SARS-CoV-2 genome that might be an ideal target for future drugs.

21 Jul 2021

Study unravels gene expression control mechanism with immunity and cancer implications

Despite alternative polyadenylation (APA) affecting a larger part of human genes, the importance of APA was not well understood.

21 Jul 2021

New study could prevent T cell exhaustion in the immune system’s fight against cancer

Struggling against a tumor is not a sprint. It is a marathon. The race of cancer-fighting T cells is at times simply very long, and the T cells give up fighting. This phenomenon is referred to as T cell exhaustion by researchers.

21 Jul 2021

Study shows how single cells take up fatty acids, offering new insights into cancer biology

Researchers have developed a new method that offers novel insights into cancer biology by enabling them to unravel how single cells absorb fatty acids.

21 Jul 2021

$Microcrystal electron diffraction could help obtain potential pharmaceutical structures$

Microcrystal electron diffraction could help obtain potential pharmaceutical structures

In the process of drug development, solving structures of potential therapeutics with X-ray diffraction (XRD) has been a presumed, critical step so far.

16 Jul 2021

Synthesis of complete crenarchaeol molecule elucidates its structure

Crenarchaeol is a large, closed-loop lipid that is present in the membranes of ammonium-oxidizing archaea, a unicellular life form that exists ubiquitously in the oceans.

14 Jul 2021

Researchers identify a novel pathomechanism leading to Usher syndrome

Human Usher syndrome (USH) is the most common form of hereditary deaf-blindness. Sufferers can be deaf from birth, suffer from balance disorders, and eventually lose their eyesight as the disease progresses.

12 Jul 2021

Study reveals the relationship between gut microbiome and neurodegenerative disorders

Eran Blacher bagged the NOSTER & Science Microbiome Prize 2021 for his work in highlighting the relationship between the microbiome and neurodegenerative diseases.

12 Jul 2021

Engineered enzyme facilitates more effective plastic degradation

Plastic was previously considered a manufacturing miracle as it was inexpensive to produce.

9 Jul 2021

Protein's 'silent code' influences cell movement

The protein actin is ubiquitous and essential for life. In mammals, every cell expresses two of its forms, beta-actin and gamma-nonmuscle-actin. Despite having distinct roles, the two forms are nearly identical, sharing 99% of their amino acid sequence.

8 Jul 2021

Molecule News and Research

Already characterized active substances exhibit unexpected effects

New study uncovers how enterococcal cytolysins affect cells

Researchers discover nucleotide sequences characteristic of microRNA isoforms

Study identifies many small molecules that bind to certain areas of the SARS-CoV-2 genome

Study unravels gene expression control mechanism with immunity and cancer implications

New study could prevent T cell exhaustion in the immune system’s fight against cancer

Study shows how single cells take up fatty acids, offering new insights into cancer biology

Microcrystal electron diffraction could help obtain potential pharmaceutical structures

Synthesis of complete crenarchaeol molecule elucidates its structure

Researchers identify a novel pathomechanism leading to Usher syndrome

Study reveals the relationship between gut microbiome and neurodegenerative disorders

Engineered enzyme facilitates more effective plastic degradation

Protein's 'silent code' influences cell movement

Meat and meat-based substitutes vary widely in their nutritional content

New method for generating metabolic profiles of individual cells

Deep machine learning adds to the knowledge of one million molecules’ bioactivity

New tool sheds light on enzymatic activity linked to blood cancers, heart disease

A new method to efficiently produce biofuels from discarded plant matter

WEHI partners with Boehringer Ingelheim to develop novel anti-cancer therapeutics

Protein known to mediate cell death plays a key role in maturation and release of interleukin-1α

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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