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Functions of gamma delta T cells are regulated by sugars and fat Gene, shows study

The team led by Bruno Silva Santos, Principal Investigator and Deputy Director of the Instituto de Medicina Molecular João Lobo Antunes (iMM) and Professor at the Faculdade de Medicina da Universidade de Lisboa, discovered that the functions of a subtype of white blood cells - gamma delta T cells - are regulated by metabolic resources, namely sugars and fat.

20 Jan 2021

Study shows how nonmalignant cells adapt to harsh tumor microenvironment

Cells need energy to survive and thrive. Generally, if oxygen is available, cells will oxidize glucose to carbon dioxide, which is very efficient, much like burning gasoline in your car. However, even in the presence of adequate oxygen, many malignant cells choose instead to ferment glucose to lactic acid, which is a much less efficient process.

20 Jan 2021

Researchers define cancer invasion machinery orchestrated by cancer gene

Researchers at the University of Helsinki have defined a cancer invasion machinery, which is orchestrated by a frequently mutated cancer gene called Ras. When signaling from Ras protein becomes abnormally high, like it does in many cancers, this switches on the cellular machinery that helps the cancer cells to depart from the tissue from which the cells have developed.

20 Jan 2021

New computational technique accurately differentiates between normal and cancer cells

Scientists have created a new method to precisely differentiate between data from a wide range of normal cells and cancer cells found inside tumor samples.

19 Jan 2021

New mathematical model captures forces involved in cell movement

Physicists have teamed up to find out the precise mechanisms that play a crucial role in cell motility.

19 Jan 2021

Researchers develop more effective personalized immunotherapy for cancer patients

New research from CU Cancer Center member Jing Hong Wang, MD, PhD, and recent University of Colorado Immunology program graduate Rachel Woolaver, PhD, may help researchers develop more effective personalized immunotherapy for cancer patients.

15 Jan 2021

Targeting RNA splicing can trigger antiviral immune pathways in triple-negative breast cancers

Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response.

15 Jan 2021

Protein phosphatase inhibition could contribute to the treatment of cancer, other diseases

The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential.

13 Jan 2021

Proteogenomic study may lead to more effective treatments for head and neck squamous cell carcinoma

Proteogenomic studies may provide a better understanding of how to match cancer patients with an effective treatment for their specific cancer.

8 Jan 2021

Researchers create molecular ON-OFF switches to regulate CAR T cell activity

CAR T cells are a breakthrough class of effective but often toxic cancer therapies. To prevent overactivation, switchable CAR T cells were engineered that can be turned on and off with an approved, widely used cancer drug.

7 Jan 2021

Microbe found in the colon may promote breast cancers

A microbe found in the colon and commonly associated with the development of colitis and colon cancer also may play a role in the development of some breast cancers, according to new research from investigators with the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

7 Jan 2021

Researchers identify a vital protein needed to regulate anti-tumor immune response

Scientists from The University of Texas MD Anderson Cancer Center have identified a protein known as NF-kappa B-inducing kinase (NIK).

5 Jan 2021

Combination method can boost immunotherapy for breast cancer

According to a new study performed by scientists from the University of North Carolina, stimulating an immune signaling pathway, which is best known for combating bacterial and viral infections, can increase the potential of genetically engineered T cells to remove breast cancer in mice.

4 Jan 2021

Chromosomal instability is associated with cancer's aggressiveness

Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether.

29 Dec 2020

TUM researcher develops self-learning algorithms to help analyze bioscientific image data

Imaging techniques enable a detailed look inside an organism. But interpreting the data is time-consuming and requires a great deal of experience.

29 Dec 2020

Triple drug combination keeps people with metastatic colon cancer disease free for longer time

Researchers from SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), part of the National Institutes of Health, have shown that a triple drug combination - of irinotecan, cetuximab, and vemurafenib - is a more powerful tumor fighter and keeps people with metastatic colon cancer disease free for a significantly longer period of time compared with patients treated with irinotecan and cetuximab.

24 Dec 2020

New tantalum-laced composite hydrogel controls excessive bleeding in the body

There are many different events that may lead to excessive and uncontrolled bleeding within the body. This can occur as a result of inflammation and ulcerations, abnormalities in the blood vessels or trauma-related injuries.

23 Dec 2020

Research sheds new light on immune system interactions with cancer

Cancers like melanoma are hard to treat, not least because they have a varied bag of tricks for defeating or evading treatments.

22 Dec 2020

Novel microscope could allow surgeons to inspect cancer margins in minutes

When surgeons remove cancer, one of the first questions is, "Did they get it all?" Researchers from Rice University and the University of Texas MD Anderson Cancer Center have created a new microscope that can quickly and inexpensively image large tissue sections, potentially during surgery, to find the answer.

21 Dec 2020

Researchers create 3D miniature organs that precisely mimic human tissues

Organoids are tissues that look like organs and are extracted from stem cells cultured in laboratories. They are usually known as miniature organs.

21 Dec 2020

Tumor News and Research

Functions of gamma delta T cells are regulated by sugars and fat Gene, shows study

Study shows how nonmalignant cells adapt to harsh tumor microenvironment

Researchers define cancer invasion machinery orchestrated by cancer gene

New computational technique accurately differentiates between normal and cancer cells

New mathematical model captures forces involved in cell movement

Researchers develop more effective personalized immunotherapy for cancer patients

Targeting RNA splicing can trigger antiviral immune pathways in triple-negative breast cancers

Protein phosphatase inhibition could contribute to the treatment of cancer, other diseases

Proteogenomic study may lead to more effective treatments for head and neck squamous cell carcinoma

Researchers create molecular ON-OFF switches to regulate CAR T cell activity

Microbe found in the colon may promote breast cancers

Researchers identify a vital protein needed to regulate anti-tumor immune response

Combination method can boost immunotherapy for breast cancer

Chromosomal instability is associated with cancer's aggressiveness

TUM researcher develops self-learning algorithms to help analyze bioscientific image data

Triple drug combination keeps people with metastatic colon cancer disease free for longer time

New tantalum-laced composite hydrogel controls excessive bleeding in the body

Research sheds new light on immune system interactions with cancer

Novel microscope could allow surgeons to inspect cancer margins in minutes

Researchers create 3D miniature organs that precisely mimic human tissues

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