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New Study Reveals DNA’s Role in Stabilizing Cellular Structures

In a discovery that could redefine how we understand cellular resilience and adaptability, scientists at Scripps Research have unlocked the secret interactions between a primordial inorganic polymer of phosphate known as polyphosphate (polyP), and two basic building blocks of life: DNA and the element magnesium.

26 Dec 2024

New Method Improves Quantification of Endocytosis in Living Cells

Living cells and tissues show a high capacity to absorb various chemical compounds from the surrounding environment.

23 Dec 2024

New Synthetic Biology Tool Improves Genetic Circuit Integration and Functionality

The research team led by Professor Jongmin Kim from the Department of Life Sciences at POSTECH, along with graduate students Hyunseop Goh and Seungdo Choi, has successfully developed the 'Synthetic Translational Coupling Element (SynTCE),' significantly enhancing the precision and integration density of genetic circuits in synthetic biology.

23 Dec 2024

High-Resolution Technique Maps Ribosome Elongation Cycle

At one time or another, most of us have played with a flipbook, using our thumbs to rapidly flip a series of pictures to create an illusion of movement.

20 Dec 2024

A Novel Method for Synthesizing Piperidines for Modern Medicine

A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines biocatalytic carbon-hydrogen oxidation and radical cross-coupling, offering a streamlined and cost-effective approach to create complex, three-dimensional molecules.

19 Dec 2024

Neural Stem Cells Found to Rejuvenate the Aging Brain

Much like plants in a thriving forest, certain cells in the brain create a nurturing environment, enhancing the health and resilience of their neighbors, while others promote stress and damage, akin to a noxious weed in an ecosystem.

19 Dec 2024

Scientists Mimic Fungal Process to Create Novel Medicines

Since the unintentional 1928 discovery of penicillin by Alexander Fleming, fungi have been a treasure trove of medicinal compounds for almost a century.

19 Dec 2024

Researchers Map Influenza Virus RNA Protective Coat at Atomic Level

To fight the virus that causes influenza, one of the avenues being explored by scientists is the development of drugs capable of destabilizing its genome, made up of eight RNA molecules.

17 Dec 2024

Advancing Sequential DNA Computing for Programmable Devices

DNA stores the instructions for life and, along with enzymes and other molecules, computes everything from hair color to risk of developing diseases.

13 Dec 2024

Programmable G-protein-coupled receptors redefine therapeutic applications.

This study demonstrates the development of PAGERs (programmable antigen-gated engineered receptors), combining antigen specificity, modular adaptability, and drug-controlled activation, with potential applications in synthetic biology, therapeutics, and neuroscience.

12 Dec 2024

Ribosomal Fingerprints: A Novel Approach to Early Cancer Detection

Different types of cancer have unique molecular 'fingerprints' which are detectable in early stages of the disease and can be picked up with near-perfect accuracy by small, portable scanners in just a few hours, according to a study published today in the journal Molecular Cell.

11 Dec 2024

Evolution of Chloroplasts from Energy Providers to Carbon Fixers

Endosymbiosis, the process by which one organism engulfed another and integrated its DNA and functions into itself rather than ingesting it, was one of the most significant events in the history of life.

11 Dec 2024

Novel Approach to Monitor ER-Related Protein Quality Control

Protein synthesis in eukaryotic cells found in plants, animals, and fungi involves more than just the straightforward ribosome assembly of amino acids.

9 Dec 2024

SigRM Advances Single-Cell Research by Mapping RNA Modifications

Researchers have developed a new tool that will help scientists study how genes are expressed in our cells.

6 Dec 2024

New Discovery Reveals Unintended Genetic Damage in CRISPR-Cas9 Therapy

Genome editing with various CRISPR-Cas molecule complexes has progressed rapidly in recent years.

5 Dec 2024

Unraveling the Mystery of Bacterial Protein Synthesis

The process by which cells make protein molecules, which are necessary for life and growth, is known as protein biosynthesis, and it is a very complicated and tightly controlled process.

5 Dec 2024

Cancer-Associated Gene MYC Found to Drive Muscle Growth Independently of Exercise

Researchers have long known that there is a relationship between the cancer-associated gene MYC (pronounced "Mick") and exercise adaptation.

4 Dec 2024

Research Sheds Light on Protein's Role in Enhancing Plant Disease Resistance

Salicylic acid is vital for protecting plants from pathogens, but its synthesis remains unclear. A recent study by Shinshu University researchers has discovered that the protein HSR201 is key to its production.

3 Dec 2024

New Artificial Adhesion System Closely Mimics Natural Biological Interactions

In a first-of-its-kind breakthrough, a team of UBC Okanagan researchers has developed an artificial adhesion system that closely mimics natural biological interactions.

3 Dec 2024

Understanding Gut Inflammation Through RNA Sequencing

This study creates a comprehensive atlas of gastrointestinal cell types, revealing how stem cell-derived INFLAREs drive inflammation in chronic diseases.

29 Nov 2024