Autoimmunity News and Research

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Autoimmune Disease is a condition in which the body recognizes its own tissues as foreign and directs an immune response against them.

CRISPR Screen Uncovers COMPASS Pathway Role in Suppressing Gut Autoimmunity

3 Nov 2026

Aberrant RNA Splicing Generates Immunogenic Neoantigens in Systemic Lupus

Scientists at La Jolla Institute for Immunology (LJI) and the University of Washington (UW) have discovered that patients with lupus have unusual mutations that may turn their bodies into battlegrounds.

30 Oct 2026

St. Jude Scientists Discover Gene-Regulatory Pathway Protecting Gut Immune Balance

Trillions of bacteria live in the human gut without triggering an immune response. Scientists at St. Jude Children's Research Hospital have now discovered a gene-regulatory pathway that helps maintain this delicate balance. Published today in Science Advances, they showed that a type of immune cell, regulatory T cells, co-opt a well-known general gene expression pathway called COMPASS to suppress inappropriate immune responses and prevent lethal inflammation and autoimmunity.

30 Oct 2026

Researchers Track Harmful Post COVID Autoantibodies to Specific B Cells

When the immune system encounters a virus, it produces antibodies designed to recognize and eliminate the invader.

31 Aug 2026

Reengineering Glial Cell Signaling Pathways to Slow Down ALS Symptoms

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, according to the CDC, currently impacts around 35,000 Americans-with 5,000 more diagnosed each year.

21 Aug 2026

Synthetic Biology Breakthrough Rebuilds Basic Features of Cellular Life

Nature is beautiful, powerful and essential. But nature is not always gentle. The same biological world that gives rise to forests, coral reefs and human life also produces infections, cancer, genetic disease, crop blights and toxins.

24 Jul 2026

Innovative Bioelectronic Ear Devices Offer New Hope for Asthma Relief

Neuroimmunology, the study of interactions between the nervous and immune systems, is a rapidly growing field enabling new approaches for monitoring and treating inflammatory diseases.

16 Jul 2026

Targeting Fibroblast Communication Could Halt Primary Sjögren Disease Damage

In autoimmune disorders, immune cells targeting 'self' proteins are mistakenly activated, resulting in their abnormal expansion and responsiveness. It has been known to reduce the quality of life of patients over a prolonged period.

25 Jun 2026

Real-Time Molecular Tool Observes Complex Immune System Changes

A lot of things need to go right on a molecular level for immune cells to launch an adaptive response to an infection.

24 Jun 2026

Why Women Face a Much Higher Risk of Autoimmune Disease

A recent study has identified biological abnormalities that make the female immune system more likely to mistakenly attack the body's own healthy tissues, providing insight into why women are significantly more likely than men to experience autoimmune diseases.

8 May 2026

Discovery Shows How Plants Prevent Excess Immune Responses

Salicylic acid, the active molecule in aspirin and some acne medications, is a hormone in plants that is essential for immunity, but it's a double-edged sword: Too much can cause autoimmunity and stunt growth.

5 May 2026

Gene Editing Reprograms Immune System to Produce Therapeutic Proteins

An innovative gene-editing strategy could establish a new way for the body to manufacture therapeutic proteins-including certain kinds of highly potent antibodies the are naturally difficult to produce-by reprogramming the immune system itself.

20 Apr 2026

Identifying Somatic Driver Mutations in Thyroid Autoimmune Disease

According to recent studies, immune cell DNA mutations that eliminate the immune system's natural brakes may be the cause of autoimmune disorders.

15 Apr 2026

Research Shows Successful Recovery of Antigen-Specific T Cells in Mouse Models

Researchers at The Jackson Laboratory (JAX), in collaboration with the Massachusetts Institute of Technology (MIT), have developed the first bandage-like microneedle patch that can sample the body's immune responses painlessly from the skin. The device detects inflammatory signals within minutes and collects specialized immune cells within hours without the need for blood draws or surgical biopsies.

3 Mar 2026

Engineered CD4 CAR T Cells Reduce Amyloid Plaques in Alzheimer’s

Findings suggest engineered CD4+ T cells can modify Alzheimer's pathology and improve CNS immune responses, highlighting a novel therapeutic approach.

19 Feb 2026

Innovative mRNA Technology Rejuvenates Aging Immune System in Mice

Can the weakened immune systems of older individuals be rejuvenated? Researchers from the German Cancer Research Center (DKFZ), the HI-STEM institute, and the Broad Institute have demonstrated that this is possible with an innovative approach.

18 Dec 2025

Deciphering PARP14's Role in Viral Pathogenesis

Researchers at the University of Kansas have identified that the human gene encoding the protein PARP14 plays a crucial role in regulating interferon, a key component of the body’s innate immune system.

12 Nov 2025

Using AI and "Protein Language" Models to Speed Monoclonal Antibody Design

Artificial intelligence (AI) and "protein language" models can speed the design of monoclonal antibodies that prevent or reduce the severity of potentially life-threatening viral infections, according to a multi-institutional study led by researchers at Vanderbilt University Medical Center.

6 Nov 2025

Study Identifies Dcir as a Brake on Immune Responses to Aspergillus Infection

People are exposed to millions of fungal spores every day, even potentially harmful ones like those from Aspergillus fumigatus.

13 Sep 2025

Scientists Uncover Hidden Role of Cas9 in Building Bacterial Immune Memory

When scientists discovered how bacteria protect themselves against viral invaders, called phages, in the early 2000s, little did they know they'd stumbled upon a revolutionary tool researchers could use to edit the DNA of living cells.

4 Sep 2025