Conjugation News and Research

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Zinc Inhibits Plasmid Transfer in Gut Microbes

Genes responsible for antimicrobial resistance (AMR) can spread from microbe to microbe through circular genetic material called plasmids, and this lateral transfer occurs in the gut. This week in Applied and Environmental Microbiology, researchers in Iowa report that the transmission of some AMR plasmids may be inhibited by a readily available source-;dietary zinc supplements.

4 Oct 2024

Insights into the Formation of Nascent Membrane Structures in Yeast Sporulation

Sexual reproduction, a common mode of reproduction among numerous species, involves gametogenesis in which offspring are produced through fertilization, conjugation, or mating. In plants and animals, eggs and sperm differentiate from germ cells to form gametes.

30 Sep 2024

CRISPR-Cas Vs. Anti-CRISPR Proteins: The Battle Over Antibiotic Resistance In Bacteria

The relationship between antibiotic resistance in bacteria and the interactions between the CRISPR-Cas system and anti-CRISPR proteins.

30 Jul 2024

The Evolution of CRISPR Technology in Combatting Antimicrobial Resistance

Assistant Professor Ibrahim Bitar of the Department of Microbiology, Faculty of Medicine, University Hospital in Plzen, Charles University in Prague, Plzen, Czech Republic, will provide an overview of the molecular biology of CRISPR technology and highlight its potential applications in combating antimicrobial resistance in the second new research review.

29 Apr 2024

Study Investigates Antibiotic Resistance Genes Transfer Between Bacteria

A recent study reported in The Lancet Microbe reveals that the exchange of antibiotic resistance genes among diverse bacteria is significantly more extensive than previously believed.

11 Dec 2023

Biotium Launches New Line of Extensively Validated Primary Antibody Conjugates for Flow Cytometry

Biotium, a leading provider of innovative solutions for life science research, is thrilled to announce the launch of Biotium Choice primary antibody conjugates. With careful curation, and extensive in-house validation, Biotium Choice monoclonal primary antibodies are designed to deliver exceptional performance for flow cytometry.

From Biotium, Inc. 6 Dec 2023

“Sugar” Molecule in Cells Plays Crucial Role in Disease Prevention

The body’s inherent production of a sugar-based molecule plays a crucial role in various cellular functions, including growth, differentiation into different cell types, self-destruction if necessary, and more.

29 Nov 2023

Chung-Ang University Researchers Develop Novel DNA Biosensor for Early Diagnosis of Cervical Cancer

The electrochemical sensor, made of a graphitic nano-onion/molybdenum disulfide nanosheet composite, detects human papillomavirus (HPV)-16 and HPV-18, with high specificity.

8 Sep 2023

Applied Cells Inc. and GenScript enter strategic collaboration to deliver combined solutions for cell therapy development

November 18th, 2022. Today, Applied Cells Inc. and GenScript USA Incorporated announced their strategic collaboration to deliver combined cell isolation solutions for cell therapy drug development worldwide. Under this collaboration, GenScript will develop and supply its proprietary research and cGMP grade CytoSinct™ reagents for use in developing CAR-T and other Cell Therapy products on the Applied Cells MARS® Platform.

25 Nov 2022

Re-defining the limits of single batch assay stabilisation

In response to increasing demand for stabilised molecular diagnostic assays, we have significantly increased our single batch lyophilised reagent bead manufacturing throughput to 300,000 reactions per freeze drying run and are now progressing towards a capacity of 100 million tests per annum.

From Biofortuna Limited 22 Aug 2022

Microcolonies in the GI tract comprise an important niche for cell-cell signaling and plasmid transfer

Published in Nature Communications, research from the University of Minnesota and Mayo Clinic sought to understand how microbial communities help people resist pathogens.

11 Apr 2022

Researchers develop a simple and effective strategy to synthesize site-specific antibody–drug conjugates

Antibody-drug conjugates, an intricate that covalently links a potent cytotoxin to an antibody, have piqued the interest of researchers as a new bio-therapeutic methodology.

14 Feb 2022

Novel platform enables sequence-unconstrained traceless protein synthesis

According to recent research published a multi-enzyme platform was created for sequence-unconstrained traceless protein synthesis and modification.

26 Oct 2021

New technology efficiently delivers immune checkpoint inhibitors for treating brain tumors

Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering.

12 Oct 2021

New transferrable and integrative type I CRISPR-based platform to efficiently edit superbugs

A research team led by Dr Aixin YAN, Associate Professor from the Research Division for Molecular & Cell Biology, Faculty of Science, in collaboration with Honorary Clinical Professor Patrick CY WOO from the Department of Microbiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, reported the development of a transferrable and integrative type I CRISPR-based platform.

23 Jul 2021

Antibiotic resistance may be spreading much faster than expected

Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers.

21 Jan 2021

Study demonstrates utility of novel method in fluorescent labeling

Thirty years ago, the cloning of the green fluorescent protein GFP, together with genetic engineering tools, revolutionized the field by enabling researchers to fuse a fluorescent 'beacon' to any protein of interest so that it can be directly observed in living cells using fluorescence microscopy.

16 Nov 2020

New technology to rapidly create antibody-drug conjugates

A USC School of Pharmacy-led team has engineered a new, faster way to make drugs that precisely target malignant cells - while leaving healthy tissue undamaged - that could lead the way to better treatments for numerous types of cancer.

5 Jun 2020