Cytoplasm News and Research

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Chemistry Breakthrough Improves Gene Delivery, Reduces Side Effects

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells.

5 Feb 2026

How DNA Leakage into the Cytoplasm Drives Ruijs-Aalfs Syndrome

Although DNA is tightly packed and safeguarded within the cell nucleus, it remains continually at risk of damage from normal metabolic activity and external stressors such as radiation and chemical agents.

2 Feb 2026

Defective DNA Protein Repair Triggers Inflammation and Premature Aging

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature aging and embryonic lethality in mice.

31 Jan 2026

Coordinated Gene Regulation Drives Saponin Production

Triterpenoid saponins are widely valued for their diverse pharmacological activities and also play important defensive roles in plants.

22 Jan 2026

Giant Virus with A Massive Genome and Unusual Infection Strategy

Ushikuvirus, a newly identified giant virus, showcases unique cytopathic effects and structural features, enhancing knowledge of viral evolution and diversity.

14 Jan 2026

Giant Ushikuvirus Discovery Sheds Light on the Origins of Life

The origin of life on Earth becomes even more fascinating and complex as we peer into the mysterious world of viruses.

8 Jan 2026

UT Southwestern Researchers Design Tau Protein to Combat Neurodegenerative Diseases

A designer version of the tau protein, developed by a team led by UT Southwestern Medical Center researchers, maintains its biological function while resisting aggregation, a pathological trait linked to neurodegenerative diseases called tauopathies. These findings, reported in Structure, could lead to new treatments for conditions including Alzheimer's disease, frontotemporal dementia, chronic traumatic encephalopathy (CTE), and progressive supranuclear palsy.

24 Dec 2025

Scientists Uncover Inner Workings of Biomolecular Condensates Linked to ALS

Inside the cell reside many tiny assembly factories and warehouses that gather together all of the proteins and RNAs-which carry out instructions from our DNA-that a living being needs.

27 Nov 2025

Inter-Organelle Crosstalk Regulates Protein Biogenesis in Eukaryotic Cells

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions between organelles are important for regulating cellular processes.

11 Nov 2025

Scientists Uncover How "P Bodies" Guide Stem Cells to Their Destinies

How do stem cells know what to become? Nearly three decades after scientists isolated the first human embryonic stem cells, researchers are still working hard to understand precisely how a single, undifferentiated cell can become any one of the roughly 200 cell types that make up the human body.

4 Nov 2025

Mapping the Molecular Choreography of Nuclear Pore Transport

Nuclear pore complexes (NPCs) are tiny but sophisticated gatekeepers that control the flow of materials between a cell's nucleus and its cytoplasm by quickly selecting which molecules to transport across the nuclear membrane.

22 Oct 2025

New Computational Tool Tracks How Genetic Variants Affect mRNA Stability

A pizza shop with 30 delivery people ought to be able to deliver a lot of pizzas - if their cars don't break down on the way.

8 Sep 2025

Rewriting rRNA Alters the Architecture of the Nucleolus

Ribosomes carry out the cell's most essential function-translating genetic information into proteins.

28 Jul 2025

Chromosome Imbalance Disrupts Mitochondria Through Protein Aggregates

It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances.

30 Jun 2025

Study Finds Protein Cleavage Essential for Healthy Cilia and Cell Signaling

New research by Sumeda Nandadasa, PhD, reveals how a key protein associated with Meckel-Gruber syndrome, nephronophthisis, Joubert syndrome and other ciliopathies is cut in half to perform two separate functions, both of which are fundamental to the healthy development of children.

30 Jun 2025

Nucleus Identified as the Pacemaker of Cell Division

Researchers at the Francis Crick Institute have shown that the 'pacemaker' controlling yeast cell division lies inside the nucleus rather than outside it, as previously thought.

26 Jun 2025

Myosin XI Helps Plants Absorb Boron Under Nutrient Stress

Boron, though required only in minimal amounts, is vital for plant development. It strengthens cell walls and supports the growth of roots and shoots.

9 Jun 2025

UC Davis Study Links Specific microRNAs to Mental and Neurological Disorders

A study in Nature Aging from researchers at the UC Davis School of Medicine has identified specific microRNAs - non-coding RNAs that regulate gene expression within cells - that likely contribute to bipolar disorder, depression, schizophrenia, post-traumatic stress disorder (PTSD) and Parkinson's disease.

5 Jun 2025

Autophagy: A Double-Edged Sword in Cancer and Protein Conformational Disorders

A new FEBS Letters review explores the dual role of autophagy in cancer and protein misfolding diseases—highlighting its potential as a therapeutic target and the challenges of tipping the balance between protection and harm.

20 May 2025

Study Reveals How Cells Process and Degrade mRNA Vaccines

A team of researchers led by Dr. Kim V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of mRNA vaccines and therapeutics.

4 Apr 2025