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Revolutionary Technique Produces Trillions of Healthy Endothelial Cells

Revolutionary Technique Produces Trillions of Healthy Endothelial Cells

Scientists have discovered a method to induce human endothelial cells from a small biopsy sample to multiply in the laboratory, producing more than enough cells to replace damaged blood vessels or nourish organs for transplantation, according to a preclinical study by Weill Cornell Medicine investigators.

15 Oct 2025

Acidic Tumor Environment Found to Rewire Cancer Cell Metabolism

Acidic Tumor Environment Found to Rewire Cancer Cell Metabolism

Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells.

10 Oct 2025

Intergenerational Transmission of Exercise Benefits Mediated by Sperm MicroRNAs

Intergenerational Transmission of Exercise Benefits Mediated by Sperm MicroRNAs

n a recent study published in Cell Metabolism, a collaborative research team led by Chen-Yu Zhang, Xi Chen, and Di-Jun Chen from Nanjing University, together with Tao Zhang from Nanjing Medical University, reported groundbreaking findings in their paper entitled "Paternal exercise confers endurance capacity to offspring through sperm microRNAs."

7 Oct 2025

Alpha Cells may Produce More Bioactive GLP-1 Than Previously Believed

Alpha Cells may Produce More Bioactive GLP-1 Than Previously Believed

A new study from Duke University School of Medicine is challenging long-standing views on blood sugar regulation - and pointing to a surprising new ally in the fight against type 2 diabetes.

22 Sep 2025

Editing SlVI Gene Enhances Sugar Content and Disease Resistance in Tomato Fruit

Editing SlVI Gene Enhances Sugar Content and Disease Resistance in Tomato Fruit

Tomato fruit development relies on complex sugar metabolism, including the conversion of stored starch into sucrose, glucose, and fructose.

22 Sep 2025

Carbon Starvation Drives Metabolic and Epigenetic Reprogramming in Grapevine Cells

Carbon Starvation Drives Metabolic and Epigenetic Reprogramming in Grapevine Cells

Plants rely on sugars not only as energy sources but also as regulators of cellular activities. Carbon starvation disrupts central metabolism, impairs growth, and forces cells to recycle stored resources.

18 Sep 2025

Genes Actively Work to Shape a Healthy Gut Microbiome

Genes Actively Work to Shape a Healthy Gut Microbiome

New research from the University of Sydney's Charles Perkins Centre has found that genes play an active role in shaping the bacteria found in our gut, questioning the idea that gut health is influenced only by diet.

11 Sep 2025

Scientists Engineer E. Coli To Produce Plastic-Building Chemical

Scientists Engineer E. Coli To Produce Plastic-Building Chemical

This study reveals a novel pathway in E. coli for synthesizing 2,5-pyridinedicarboxylate from glucose, offering a sustainable alternative to fossil fuels.

10 Sep 2025

Breakthrough Technique Enables Large-Scale Study of Polar and Ionic Metabolites

Breakthrough Technique Enables Large-Scale Study of Polar and Ionic Metabolites

Researchers from the McCullagh Group in Oxford University's Department of Chemistry have published an innovative method in Nature Protocols today (22 August) that provides comprehensive analysis of metabolites found in cells, tissues and biofluids.

22 Aug 2025

Automated 15-minute, Aseptic Micro-Sampling of T Cells

Automated 15-minute, Aseptic Micro-Sampling of T Cells

Auto-CeSS is an automated system for aseptic 30 μL sample collection, enhancing process monitoring and reducing contamination in cell therapy manufacturing.

13 Aug 2025

Smaller Scale Mutations in HNF1A Gene Nudge Millions Toward Type-2 Diabetes

Smaller Scale Mutations in HNF1A Gene Nudge Millions Toward Type-2 Diabetes

Mutations in a single gene, HNF1A, are known to cause MODY3, a rare, early onset form of diabetes.

7 Aug 2025

Misfolded Proteins in Mitochondria Linked to Type 2 Diabetes

Misfolded Proteins in Mitochondria Linked to Type 2 Diabetes

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding.

23 Jul 2025

New Computational Tool Enhances Gene Discovery in Heart and Metabolic Diseases

New Computational Tool Enhances Gene Discovery in Heart and Metabolic Diseases

Genetic changes can signal evidence of disease, but pinpointing which genes and what's changed can be difficult.

16 Jul 2025

New Insights into Cell Membrane Energy Waves

New Insights into Cell Membrane Energy Waves

Johns Hopkins researchers identify energy-generating waves on cancer cell membranes, revealing potential targets for slowing tumor growth and spread.

9 Jul 2025

Improved Bacterial Rubisco Offers Hope for Enhancing Plant Photosynthesis

Improved Bacterial Rubisco Offers Hope for Enhancing Plant Photosynthesis

During photosynthesis, an enzyme called rubisco catalyzes a key reaction - the incorporation of carbon dioxide into organic compounds to create sugars.

8 Jul 2025

Genetically Similar Bacteria Show Unexpected Diversity in Shape and Behavior

Genetically Similar Bacteria Show Unexpected Diversity in Shape and Behavior

Genetically similar bacteria can differ in shape and behavior, even in lab settings. A recent study shows that this variability impacts microbial fitness, virulence, and our understanding of gut microbiota.

26 Jun 2025

New Technique Enhances Three Dimensional Immunolabeling in Thick Tissues

New Technique Enhances Three Dimensional Immunolabeling in Thick Tissues

Three dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and molecules in intact tissues.

20 Jun 2025

Study Reveals TRF's Role in Reshaping Gut Microbiome and Metabolism

Study Reveals TRF's Role in Reshaping Gut Microbiome and Metabolism

Metatranscriptomics uncovers how time-restricted feeding restores gut microbial cycles, offering insights into improving metabolic health and disease treatment.

20 Jun 2025

New Stem Cell Islet Model Mimics Pancreatic Function More Accurately

New Stem Cell Islet Model Mimics Pancreatic Function More Accurately

Researchers led by Maike Sander, Scientific Director of the Max Delbrück Center, have developed a vascularized organoid model of hormone secreting cells in the pancreas.

24 May 2025

Liver Energy Storage Tied to Genetic Activity in PPP1R3B

Liver Energy Storage Tied to Genetic Activity in PPP1R3B

A new study published in Science Advances reveals that a single gene plays a big role in how the liver stores energy, a process that's critical for overall health and for managing diseases like type 2 diabetes.

19 May 2025

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