Biochemistry

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AI-Driven Design of Soluble Protein Analogs for Drug Discovery and Antibody Development

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

24 Jun 2024

Study Identifies Three Distinct Subtypes of Clear Cell Renal Cell Carcinoma Using Radiomics and Transcriptomics

Using transcriptomics and radiomics data clustering and its association with molecular characteristics, clinical pathologies, and prognosis to define intrinsic subtypes of ccRCC.

24 Jun 2024

Study Provides a New Way to Measure Healthy Microbiomes in the Gut and Soil

Focusing on four common diseases – diabetes, heart disease, depression and bowel cancer – new Flinders University research provides insights into the importance of a healthy microbiome balance in the human gut and in the environment.

22 Jun 2024

Boron-Mediated Photocycloaddition: Expanding Quinoline's Potential for Drug Development

An innovative synthesis strategy opened up the way to 2D/3D fused frameworks using inexpensive quinolines as feedstock, report scientists from Tokyo Tech.

21 Jun 2024

Enzymes Replace Cyanide in Eco-Friendly Nitrile Synthesis

If the household cleaner emits a lemon-like odor, it may be due to a nitrile called citronellyl nitrile. Chemical-resistant gloves, superglue, and active pharmaceutical ingredients are all made with these adaptable chemical nitrile groups.

19 Jun 2024

Mirror-Image Cyclodextrins: A Breakthrough in Drug Delivery

Cyclodextrins (CDs) are complicated carbohydrates, a term that describes the natural, sugar-based, starchy material that makes up much of fruits, vegetables and grains.

19 Jun 2024

MIT Researchers Develop Amber-Like Polymer for Room-Temperature DNA Storage

In the movie "Jurassic Park," scientists extracted DNA that had been preserved in amber for millions of years, and used it to create a population of long-extinct dinosaurs.

14 Jun 2024

Mitochondria Influence the Ability of Adult Cardiac Cells to Multiply

Whether forcing adult cardiomyocytes to reverse from the oxidative phosphorylation phenotype to the glycolysis phenotype would also restore their mitotic ability.

13 Jun 2024

Simplified Proteomics Method Could Open the Door Toward Precision Medicine

Proteins are workhorses that carry out most of the biological functions in our cells.

12 Jun 2024

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

11 Jun 2024

Discovery Speeds Up Cyclic Peptide Production for Antibiotic Development

A discovery made by scientists at King's College London could speed up efforts to produce new antibiotics in the fight against antimicrobial resistance.

11 Jun 2024

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Epitope Binning-Seq: Revolutionizing Antibody Drug Discovery

Monoclonal antibodies are powerful tools in medicine due to their remarkable ability to target specific sites on antigens (foreign invaders) called epitopes.

11 Jun 2024

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Advancements in Direct MS with Plasmion’s SICRIT®.

From Plasmion 11 Jun 2024

Peptidomimetics Unlock New Potential in Drug Discovery

Collaborating with the Universities of Bristol and Leeds, researchers at the University of Birmingham have effectively demonstrated a method for modifying peptides to transform them into potentially useful tools for drug discovery and disease diagnosis

10 Jun 2024

Biochemistry

AI-Driven Design of Soluble Protein Analogs for Drug Discovery and Antibody Development

Study Identifies Three Distinct Subtypes of Clear Cell Renal Cell Carcinoma Using Radiomics and Transcriptomics

Study Provides a New Way to Measure Healthy Microbiomes in the Gut and Soil

Boron-Mediated Photocycloaddition: Expanding Quinoline's Potential for Drug Development

Enzymes Replace Cyanide in Eco-Friendly Nitrile Synthesis

Mirror-Image Cyclodextrins: A Breakthrough in Drug Delivery

MIT Researchers Develop Amber-Like Polymer for Room-Temperature DNA Storage

Mitochondria Influence the Ability of Adult Cardiac Cells to Multiply

Simplified Proteomics Method Could Open the Door Toward Precision Medicine

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

Discovery Speeds Up Cyclic Peptide Production for Antibiotic Development

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

Epitope Binning-Seq: Revolutionizing Antibody Drug Discovery

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Peptidomimetics Unlock New Potential in Drug Discovery

Unveiling the Chemical Secrets of Coral Reefs and Insights into Marine Health

Novel Lipopeptide from Serratia marcescens Shows Promise Against Staphylococcus aureus Infections

Understanding the Chemistry of Chocolate and Genotoxic Compounds

LC-MS/MS analysis provides new insights into early childhood health and development

Inverse relationship found between anti-inflammatory macrophages and NK cells/T cells in lung cancer

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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