Genomics

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HudsonAlpha Scientists Receive NIH Grant to Enhance Genetic Testing for Rare Diseases

As genetic sequencing technology becomes more accessible and efficient, researchers have made significant strides in understanding the genetic underpinnings of various diseases. This knowledge has led to a surge in clinical applications of genetic testing, offering hope and improved outcomes for individuals affected by many genetic diseases and disorders.

5 Sep 2024

Researchers Uncover Hundreds of New Potential Cancer Driver Genes

Researchers at the Centre for Genomic Regulation (CRG) have discovered hundreds of potential new cancer driver genes.

4 Sep 2024

CRISPR/Cas System Revolutionizes Tumor Variant and Biomarker Detection

The CRISPR-Cas system is transforming tumor biomarker detection, enabling ultra-sensitive diagnostics and improving accuracy in cancer detection and monitoring.

4 Sep 2024

Genetic Variants Linked to Rare Bicuspid Aortic Valve Disease Identified

Genetic variants linked to a rare form of bicuspid aortic valve disease that affects young adults and can lead to dangerous and potentially life-threatening aortic complications have been identified by researchers at UTHealth Houston.

3 Sep 2024

Study Identifies Genes for Healthier Rice with Low Glycemic Index and High Protein

A team of researchers at the International Rice Research Institute (IRRI) has identified genes and markers responsible for low glycemic index (GI) and high protein content in rice, using genetics and artificial intelligence classification methods.

2 Sep 2024

Unexpected RNA Mechanism Controls Black Pigment in Butterfly Wings

A team of international researchers has uncovered a surprising genetic mechanism that influences the vibrant and complex patterns on butterfly wings.

2 Sep 2024

Investors Show Financial Support for Insect Farming for Poultry

Investors have poured in over £1.7 million to scale up production, sales and supply of Black Soldier Fly (BSF) eggs and larvae produced by Scottish insect genetics business Beta Bugs Ltd.

From Beta Bugs Ltd. 30 Aug 2024

AmelHap: A Honeybee Haplotype Map

Beebytes is very happy to have achieved its first publication, the development of a ‘HapMap’ for honey bees, in collaboration with the Roslin Institute, the University of the Basque Country in Spain, and the National Research Institute for Agriculture, Food and the Environment (INRAE) in France.

From Beebytes Analytics 30 Aug 2024

A Landmark Study Reveals the Widespread Existence of DNA i-Motifs

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

30 Aug 2024

Bacterial Protein Utilizes DNA for Target Recognition and Plasmid Elimination

Scientists who have described in a new study the step-by-step details of a bacterial defense strategy see the mechanism as a promising platform for development of a new genome-editing method.

30 Aug 2024

Comparative Genomics Identifies a Novel Gene Involved in Spider Patterning

An ancient gene is crucial for the development of the distinctive waist that divides the spider body plan in two, according to a study publishing August 29th in the open-access journal PLOS Biology by Emily Setton from the University of Wisconsin-Madison, US, and colleagues.

30 Aug 2024

The Influence of 'Silent' Mutations on Genetic Disorders

Genetic disorders -; like cystic fibrosis and Huntington's disease -; are considered incurable, with gene mutations occurring in essentially every cell of the body.

29 Aug 2024

Clock Genes Drive Evolutionary Split in Two Moth Species

Investigating moth speciation, this research highlights the impact of clock genes on behavior, providing a rare glimpse into evolutionary processes.

28 Aug 2024

Stem Cell Research Sheds Light on Rare Pediatric Condition

Scientists have identified mutations in the DENND5A gene that cause severe neurodevelopmental issues in infants, leading to improper brain cell division during development.

28 Aug 2024

Nile Grass Rats Become New Model for CRISPR Genome Editing

A team of researchers at Michigan State University has discovered a set of methods that enabled the first successful CRISPR-based genome editing in Nile grass rats.

27 Aug 2024

Rare CCDC201 Genotype Significantly Affects Menopause Onset in Women

Scientists at deCODE genetics and collaborators, have identified a sequence variant in the CCDC201 gene that when inherited from both parents homozygous causes menopause on average nine years earlier.

27 Aug 2024

New Discovery in Mitochondrial DNA Regulation May Halt Heritable Disease Onset

University of Queensland researchers have discovered a mechanism in DNA that regulates how disease-causing mutations are inherited.

23 Aug 2024

The Complex Link Between DNA Modification and ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease which remains incurable. The disease is characterized by the selective degeneration of upper motor neurons in the motor cortex as well as the lower motor neurons in the brainstem and spinal cord. The cause of ALS remains unknown in 90 percent of cases, which are referred to as sporadic ALS because there is no family history for the disease. Cumulative evidence suggests that sporadic ALS may result from complex interactions between genetic susceptibility and aging.

23 Aug 2024

The Role of DNA Repair Pathways in Antibody Somatic Hypermutation

In a recent online publication in SCIENCE CHINA Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine published a review article entitled "Molecular Mechanisms of DNA Lesion and Repair During Antibody Somatic Hypermutation". This review comprehensively summarizes the mechanisms involved in the generation of antigen-specific diversified antibodies, with a particular focus on the mechanisms that generate high-frequency point mutations and low-frequency deletions and insertions (indels) in antibody genes.

22 Aug 2024