Genomics

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Cryo-EM Study Reveals Cas7-11-CRISPR Complex Regulation Mechanisms

In a recent study published in Signal Transduction and Targeted Therapy, Chinese researchers studied the cryo-electron microscopy structures of the CRISPR-Cas7-11 nuclease, both alone and in complex with the regulatory protein tetratricopeptide repeat fused with Cas/(human enhancer of filamentation 1) HEF1-associated signal transducer (TPR-CHAT).

24 May 2024

Multiplexed Orthogonal Base Editors for Precise Mutation Modeling

The human genome consists of around 3 billion base pairs and humans are all 99.6% identical in their genetic makeup.

23 May 2024

Mitochondrial Phosphate Carrier MIR1: A Key Player in Candida albicans Virulence

This study is led by Professor Yan Wang (School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai, China). Her team found that the lack of MIR1 gene, which encodes mitochondrial phosphate carrier, can lead to severe virulence defects in Candida albicans.

23 May 2024

Exploring Cell-in-Cell Events Across the Tree of Life

In a new review paper, Carlo Maley and Arizona State University colleagues describe cell-in-cell phenomena in which one cell engulfs and sometimes consumes another.

22 May 2024

Insights Into Adaptation of Aspergillus flavus in Honey Bee Colonies

The past attempts of honey bee researchers to inventory the fungal diversity in honey bee colonies revealed that Aspergillus flavus is frequently found in hives.

22 May 2024

The Influence of Inherited Genes on Melanoma Risk

Most people associate skin cancer warnings with sunburn and tanning beds. “Cancer genes” or inherited risks are associated with diseases such as breast and colon cancer.

22 May 2024

Upgraded Nipponbare Genome Assembly Paves the Way for Enhanced Rice Research

A research team has achieved a groundbreaking improvement in the haplotype-resolved genome sequence of the japonica rice cultivar Nipponbare.

21 May 2024

Mapping Neurodevelopmental Disease with High-Throughput In Vivo Perturb-seq

The brain is often referred to as a "black box"-;one that's difficult to peer inside and determine what's happening at any given moment.

21 May 2024

Supercomputer Simulations Unveil Mechanisms of Fruit Fly Wing Development

If fruit fly wings do not develop into the right shape, the flies will die. UC Riverside researchers have learned how fly embryo cells develop as they need to, opening a window into human development and possible treatments for birth defects.

20 May 2024

Study Reveals How Sweet Taste Receptor Regulates Blood Sugar and Insulin

The rich research portfolio of the Monell Chemical Senses Center on sweet taste goes way back: Monell scientists were one of four teams in 2001 that found and described the mammalian sweet taste receptor – TAS1R2-TAS1R3.

20 May 2024

Viruses Offer Efficient Delivery for Precise Plant Breeding

The application of genome editing in plant molecular breeding is hampered by the lack of straightforward and efficient methods for introducing genome editing reagents into plants, despite the technology's great potential.

20 May 2024

Sex-Specific Effects of Germline Regulation on Longevity and Repair in Vertebrates

The study revealed unexpected and sex-specific effects of germline regulation on longevity and somatic repair in vertebrates.

17 May 2024

Study: South African Leopards Exhibit Exceptional Genetic Diversity

Researchers say the discovery of very high genetic diversity in leopards found in the Highveld region of South Africa has increased the need for conservation efforts to protect leopards in the country.

16 May 2024

Herpes Gene Therapy Achieves 90% Viral Reduction in Pre-Clinical Studies

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

16 May 2024

Genetic Analysis Sheds Light on the Role of Ribosomal DNA Copy Number in Inflammation and Disease

Ribosomal DNA (rDNA) is present in hundreds of copies in the genome, but has not previously been part of genetic analyses.

16 May 2024

Runt Transcription Factor Links Regeneration and Photosynthesis in Marine Worm-Algae Symbiosis

Many organisms are far more complex than just a single species. Humans, for example, are full of a variety of microbes.

16 May 2024

Discovery of Novel Adrenal Cell Type Linked to Monogamy in Oldfield Mice

What makes the oldfield mouse steadfastly monogamous throughout its life while its closest rodent relatives are promiscuous? The answer may be a previously unknown hormone-generating cell, according to a new study published online today in Nature from scientists at Columbia's Zuckerman Institute.

16 May 2024