Genomics

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Scientists Develop EvoCAST for Efficient and Accurate Gene Insertion

Ask scientists what gene editing tool is most needed to advance gene therapy, and they'd probably describe a system that's now close to realization in the labs of Samuel Sternberg at Columbia University Vagelos College of Physicians and Surgeons and David Liu at the Broad Institute of MIT and Harvard.

16 May 2025

Real Time RNA Tracking in Plants Using Fluorescent Biosensors

RNA acts as a messenger inside cells, carrying instructions from DNA that are translated into proteins that are essential for how cells function.

15 May 2025

Loss of SOX9 Gene Linked to Aggressive Colorectal Cancer

Colorectal cancer is the second leading cause of cancer-related death globally. Although some of the molecular changes associated with colorectal cancer are known, how they contribute to cancer development is not yet well defined.

15 May 2025

Variance Analysis Enhances Genetic Risk Prediction for Blood Cell Traits

A Nature Communications study shows that incorporating variance polygenic scores (vPGS) and variance QTLs (vQTLs) improves genetic risk prediction for blood-related diseases, offering new insight into phenotype variability and lifestyle factors like alcohol intake.

15 May 2025

DiffInvex Reveals Genetic Escape Routes Used by Tumors Against Treatment

Just as species adapt over generations, our body's cells accumulate DNA changes throughout life. Most are harmless, yet a few "driver" mutations give a cell a competitive edge and can spark cancer.

14 May 2025

Danforth Technology Company Backs Startup Transforming Crop Genetics

The Danforth Technology Company (DTC) today announced the launch of Spearhead Bio, a startup pioneering a breakthrough platform to enhance the efficiency of crop genome engineering by harnessing the plant's own natural DNA.

14 May 2025

Precision Mitochondrial DNA Editing Emerges as a Breakthrough in Neurological Care

Mitochondrial DNA (mtDNA) editing has emerged as a revolutionary approach in the fight against neurodegenerative diseases (NDDs).

13 May 2025

Potential Therapeutic Target for Aggressive Colorectal Cancers

Colorectal cancer ranks as the second leading cause of cancer-related mortality worldwide.

13 May 2025

Millennia-Old Mutation Provides Clues to Modern HIV Immunity

What connections exist between a millennia-old human from the Black Sea region and contemporary HIV medicine?

12 May 2025

Grapevine Cells Show Epigenetic Shifts in Response to Sugar Starvation

Plants face constant challenges from fluctuating nutrient availability, which disrupts their growth and survival.

10 May 2025

Scientists Unlock Microbial Stress Responses with Advanced Gene Silencing

Scientists at Oak Ridge National Laboratory and the University of Colorado Boulder used a gene-silencing tool and a large library of molecular guides to understand how photosynthetic bacteria adapt to light and temperature changes.

10 May 2025

AI Designs Synthetic DNA to Control Gene Expression in Mammalian Cells

A study published today in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells.

10 May 2025

Flowers Evolve Stench by Repurposing Detox Genes

Some plants lure pollinators not with sweet fragrances, but with the rank stench of decay. In a new study, researchers show how plants pull this off.

10 May 2025

Mammal’s Lifespans Linked to Brain Size and Immune System Function, Says New Study

Why do cats generally live longer than dogs? New research suggests that longer livespans of mammals like cats could be linked to their bigger brains and more complex immune systems.

9 May 2025

Genes Influence When Babies Start Walking, Study Finds

Researchers examined over 70,000 infants’ genomic information in the first research of its kind. Eleven genetic markers were found to influence when babies begin to walk, providing a number of possibilities for more in-depth biological research.

8 May 2025

Identifying Key Genetic Elements for Plasmid Curing in E. coli

Researchers from the University of Birmingham have pinpointed crucial genetic sequences involved in a technique known as plasmid curing, which aims to “displace” antibiotic resistance genes from bacteria.

7 May 2025

Sustainability Claims in Agricultural Genomics Often Lack Clear Definitions

Analysis by University of Adelaide researchers has found that claims about sustainability are increasing in agricultural genomics research, but the term is often not well-defined, leading to potential concerns about the impact and credibility of the research.

7 May 2025