Genomics

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Insights Into the Genetic Landscape of Human Head Shape

A collaborative research team from the University of Pittsburgh and KU Leuven has identified a set of genes that influence the shape of the human head.

20 Nov 2023

New Method Removes Background Noise from CITE-Seq Data

Researchers from the Chobanian & Avedisian School of Medicine and the College of Arts & Sciences at Boston University have devised an innovative tool to address this limitation. This tool can discern and eliminate undesirable background noise originating from various sources, enhancing the precision of analysis in CITE-seq experiments.

20 Nov 2023

Scientists Discover New Class of Molecular Glue Degraders for Cancer Therapy

Cells contain molecular machinery that targets and disposes of unwanted proteins to maintain homeostasis.

17 Nov 2023

Gene Splicing Affects CD20 Expression and Response to Cancer Immunotherapy

Immunotherapies that target the CD20 antigen have revolutionized how patients with a variety of blood cancers and hematologic disorders have been treated.

17 Nov 2023

Study Uncovers Ancestry-Specific Genetic Factors in IBD

The advent of whole genome sequencing technology has prompted an explosion in research into how genetics are associated with disease risk.

17 Nov 2023

New Model Reveals How Cells Maintain Epigenetic Memory During Cell Division

Every cell in the human body contains the same genetic instructions, encoded in its DNA. However, out of about 30,000 genes, each cell expresses only those genes that it needs to become a nerve cell, immune cell, or any of the other hundreds of cell types in the body.

17 Nov 2023

Wilmot Researchers Uncover a "Genomic Tug of War" That Influences Decitabine's Effectiveness

Some patients with myelodysplastic syndromes, like acute myeloid leukemia, benefit from a chemotherapy drug called decitabine that stunts cancer growth. But many others are resistant to decatibine's effects or become resistant over time.

17 Nov 2023

The Link Between Tumor Cell Mutations and DNA-RNA Hybrids

New research indicates that chromatin and its regulatory factors play a crucial role in preventing the formation of DNA-RNA hybrids, which are linked to genomic instability and cancer.

17 Nov 2023

Circular Extrachromosomal DNA Linked to Medulloblastoma Relapse and Death

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA-;loops of DNA found outside of regular chromosomes-;are twice as likely to relapse and three times as likely to die within five years of diagnosis.

15 Nov 2023

Rare Genetic Variant Found to Protect Against Alzheimer's Disease

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

14 Nov 2023

Scientists Identify 4,749 Gene Clusters Linked to Cancer Prognosis

Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed "prognostic modules," that significantly influence the progression of 32 different types of cancer.

14 Nov 2023

LJI Scientists Uncover New Superpower of MAIT Cells

Scientists at La Jolla Institute for Immunology (LJI) are investigating a talented type of T cell.

13 Nov 2023

Quantum Biology and AI Improve CRISPR Cas9 Efficiency in Microbes

Scientists at Oak Ridge National Laboratory used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.

10 Nov 2023

Large Study Finds 187 New Genetic Variants Linked to Prostate Cancer

A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk -; 451 in all -; through a whole-genome analysis that ranks as the largest and most diverse investigation into prostate cancer genetics yet.

10 Nov 2023

Dissecting the Mechanisms Behind Selective Genomic Editing

A new study is in progress to unravel a fascinating biological mystery of how certain animals can naturally eliminate more than half of their genetic information during embryonic development.

10 Nov 2023

Examining the Link Between Sleep Alteration and Aging in Jewel Wasps

Parents of newborns might sense a rapid aging effect during the early months of sleepless nights. Currently, researchers at the University of Leicester are exploring the intriguing possibility that the key to a long and healthy life lies in a restful night's sleep and human DNA.

10 Nov 2023

Scientists Forge a Path to the World’s First Synthetic Yeast Genome

Researchers crafted a chromosome entirely from the ground up, paving the way for the creation of the inaugural synthetic yeast in the world.

9 Nov 2023

Challenging the Assumption of Genetic Homogeneity in European Ancestry

Previous studies studying the genomes of people with European heritage might have reported misleading results because they did not adequately account for population structure, according to a new study.

8 Nov 2023

Unearthing Beal’s Time Capsule: The 144-Year-Old Seed Experiment

In April of 2021, a clandestine gathering took place on the Michigan State University campus, where four plant scientists from the university unearthed a bottle filled with seeds that had been buried over 144 years ago by the renowned MSU botanist, William J. Beal.

8 Nov 2023

Genomic Sequencing Reveals Songbird’s Secrets

Researchers have deciphered the genetic foundation responsible for the striking diversity in body size that is evident among song sparrows, a cherished and widely recognized species of North American songbirds.

8 Nov 2023