Genomics

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Newly discovered gene signature accurately predicts the functioning of P53 variants

In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular Oncogenesis Program, and team have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.

7 Feb 2023

Researchers decipher genomic mechanisms involved in complex eye disease

Researchers at Tel Aviv University identified a new genetic risk factor for the complex eye disease AMD (Age-related Macular Degeneration), a leading cause for loss of eyesight at an advanced age.

7 Feb 2023

Keanumycins: An alternative in the fight against resistant fungi

Pseudomonas bacteria produce a potent antimicrobial natural product, according to scientists at the Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI).

7 Feb 2023

“Reference Epigenome” and regulatory mechanisms in wheat embryogenesis

One of the most basic and amazing processes that occur in both plants and animals is embryogenesis. It is incredible that, within a matter of weeks after fertilization, a single mother egg cell can transform into a living thing with a complex body structure.

6 Feb 2023

Researchers use AI to identify genes that are critical to a cancer cell’s survival

Researchers at the University of Sussex are using Artificial Intelligence (AI) technology to analyze different types of cancer cells to understand different gene dependencies, and to identify genes that are critical to a cell's survival.

6 Feb 2023

Groundbreaking discovery could lead to new ways of controlling gene regulation

UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery.

6 Feb 2023

Experimental optimization of prime editing to achieve high efficiency

Genome editing technologies have enormous potential for treating genetic diseases. Techniques like the extensively used CRISPR/Cas9 gene scissors target the source of the disease directly in the DNA.

3 Feb 2023

Easy-to-use method quantifies exosomal miRNAs

Most cancer diagnostic procedures, like endoscopies, biopsies, and mammograms, are stressful and invasive. Although blood samples may be a less unpleasant option, only a few forms of the disease can as of now be diagnosed this way.

2 Feb 2023

Study uncovers a link between the genetic instructions for production and perception of sex pheromones

It's almost Valentine's Day, and love is in the air. Or in the waxy coating on your skin, if you are a vinegar fly. That's where flies encounter pheromones that play an important role in regulating sexual attraction.

1 Feb 2023

Nearly two million-euro ERC Consolidator Grant supports research on fruit fly's locomotion

When we try walking in a straight line with our eyes closed, after a few steps forward we inevitably deviate from our intended path.

1 Feb 2023

Study identifies genetic mutation in the SPTSSA gene as cause of Hereditary Spastic Paraplegia

A genetic mutation in the SPTSSA gene is identified as the cause of Hereditary Spastic Paraplegia, a rare disease that causes progressive weakness, stiffness and spasticity in the lower extremities, according to a study, "SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia," published in Brain on on Jan. 30.

1 Feb 2023

Genomic study helps retrace origin and spread of Shigellosis outbreak in Seattle

A genomic study of a sustained, multidrug-resistant Shigellosis outbreak in Seattle enabled scientists to retrace its origin and spread.

1 Feb 2023

Innovative gene therapy to cure multiple eye diseases

The future treatment of individuals with various eye diseases could benefit immensely from a potential new gene therapy strategy, according to Trinity University researchers.

31 Jan 2023

Novel, more accurate computational tool for long-read RNA sequencing developed

On the journey from gene to protein, a nascent RNA molecule can be cut and joined, or spliced, in different ways before being translated into a protein.

31 Jan 2023

Anti-aging gene found in centenarians can rewind the heart's biological age by 10 years

An anti-aging gene discovered in a population of centenarians has been shown to rewind the heart's biological age by 10 years.

31 Jan 2023

Researchers discover new type of pathogenic fungus that infects potatoes

RUDN University biologists have discovered a new type of pathogenic fungus that infects potatoes and leads to massive crop loss.

31 Jan 2023

Newly discovered genetic mutation may be a root cause of severe cases of childhood glaucoma

An international team of scientists led by Mass Eye and Ear, a member of Mass General Brigham, and Boston Children's Hospital, has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, a devastating condition that runs in families and can rob children of their vision by 3 years of age.

30 Jan 2023

Evolution of mint plants' chemistry could lead to new medicines, pesticides

The mint family of herbs, which includes sage, rosemary, basil, and even woody plants like teak, offers an invigorating jolt to our senses of smell and taste.

27 Jan 2023

Collaboration across European countries accelerates the characterization of an emergent plant virus

In the 21st century, "collaboration" has become a popular buzzword, but effectively working together across disciplines and countries is easier said than done.

27 Jan 2023

Deep-learning model for zinc finger design allows reprogramming of human transcription factors

Researchers at the University of Toronto and New York University have developed a novel technology that can engineer proteins to target any stretch of DNA in the human genome, opening a door toward gene therapies for a broader range of health conditions.

27 Jan 2023

Genomics

Newly discovered gene signature accurately predicts the functioning of P53 variants

Researchers decipher genomic mechanisms involved in complex eye disease

Keanumycins: An alternative in the fight against resistant fungi

“Reference Epigenome” and regulatory mechanisms in wheat embryogenesis

Researchers use AI to identify genes that are critical to a cancer cell’s survival

Groundbreaking discovery could lead to new ways of controlling gene regulation

Experimental optimization of prime editing to achieve high efficiency

Easy-to-use method quantifies exosomal miRNAs

Study uncovers a link between the genetic instructions for production and perception of sex pheromones

Nearly two million-euro ERC Consolidator Grant supports research on fruit fly's locomotion

Study identifies genetic mutation in the SPTSSA gene as cause of Hereditary Spastic Paraplegia

Genomic study helps retrace origin and spread of Shigellosis outbreak in Seattle

Innovative gene therapy to cure multiple eye diseases

Novel, more accurate computational tool for long-read RNA sequencing developed

Anti-aging gene found in centenarians can rewind the heart's biological age by 10 years

Researchers discover new type of pathogenic fungus that infects potatoes

Newly discovered genetic mutation may be a root cause of severe cases of childhood glaucoma

Evolution of mint plants' chemistry could lead to new medicines, pesticides

Collaboration across European countries accelerates the characterization of an emergent plant virus

Deep-learning model for zinc finger design allows reprogramming of human transcription factors

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