Molecular & Structural Biology

RSS

Columbia researchers develop new blood test to measure the pace of biological aging

Researchers at Columbia University Mailman School of Public Health have developed a new blood test to measure the pace of biological aging. Based on an analysis of chemical tags on the DNA contained in white blood cells, called DNA methylation marks, the new test is named DunedinPACE, after the Dunedin Birth Cohort used to develop it.

19 Jan 2022

Changes in the activity of gene networks may explain arteriosclerosis risk

Up to 60 percent of the risk associated with coronary arteriosclerosis may be explained by changes in the activity of hundreds of genes working together in networks across several organs in the body.

13 Jan 2022

First molecular images of enzyme may help solve the mystery cause of hereditary neurodegenerative diseases

WEHI researchers have produced the first molecular images of an enzyme that controls proteins to signal and communicate with each other in human cells.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 13 Jan 2022

Experts develop AI-based binding site detection in nucleic acid macromolecules

Skoltech’s iMolecule group has created a solution that employs data on the structure of molecules to detect sites where possible drug candidates could interact.

13 Jan 2022

Researchers determine how key protein drives the defense system to fight viruses

Scientists have just found a solution to a major mystery that explains how human blood cells train the defense system against viruses. They hope that this discovery will one day allow them to better control the response and either boost or calm it as needed.

13 Jan 2022

Increasing the expression of a gene slows Alzheimer’s progression in mice

According to a recent research, enhancing the expression of one gene in cells that help the brain’s neurons, shields neurons in mouse models of Alzheimer’s disease.

13 Jan 2022

Scientists develop DNA-based fluorescent nanoantenna to evaluate protein activity

Researchers at the Université de Montréal have developed a nanoantenna to track protein movements.

13 Jan 2022

CSHL researchers spotlight the role of a previously little-known protein in leukemia

Acute myeloid leukemia (AML) is an aggressive cancer of white blood cells with few effective targeted therapies available to treat it.

12 Jan 2022

Scientists discover new Senp5S protein with crucial role in brain development

Understanding how the brain develops is crucial to formulating treatments and management protocols for a variety of developmental disorders, as well as degenerative neurological diseases. Right from the embryonic stage, brain development is facilitated by the differentiation of neurons (brain cells).

12 Jan 2022

Study may pave the way for designing next generation of artificial chromosomes for data storage

Previously, researchers from Tianjin University designed and created a 254 kb digital data carrying artificial chromosome in yeast.

12 Jan 2022

Researchers reveal molecular and cellular mechanisms that lead to tertiary lymphoid structures formation

Tertiary lymphoid structures are formations that occur outside of the lymphatic system. They contain immune cells and are similar in structure and function to lymph nodes and other lymphoid structures.

12 Jan 2022

Experts determine the assembly of proteins with specialized protein needles

Protein assembly is considered to be an essential factor for the development of ordered biological structures, but how about engineering one.

10 Jan 2022

Sampling zoo air could help collect enough DNA to identify the animals nearby

The air in a zoo is full of smells, from the fish used for feed to the manure from the grazing herbivores, but now we know it is also full of DNA from the animals living there.

7 Jan 2022

A highly effective protection against oxidative stress developed by present-day humans

Very few proteins in the body have a change that makes them unique compared to the corresponding proteins in Neanderthals and apes. Researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institute in Sweden have now studied one such protein, glutathione reductase, which protects against oxidative stress.

From The Max Planck Institute 6 Jan 2022

Scientists discover how sponginess of stem cell nuclei controls cell differentiation

Researchers from Tokyo Metropolitan University have discovered how the sponginess and stickiness of stem cell nuclei controls how they "differentiate" into specialized cells. They found that the nucleus starts solid-like but becomes more fluid-like over time.

3 Jan 2022

Blocking function of blood-clotting protein prevents bone loss from gum disease in mice

Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health.

24 Dec 2021

Unraveling how DNAzymes work in real time

DNAzymes are precision biocatalysts that destroy unwanted RNA molecules. However, major obstacles to their use in medicine remain.

23 Dec 2021

Study identifies two proteins as novel markers of aggressive prostate cancer

Prostate cancer is the most commonly diagnosed cancer in men and is among the top five causes of cancer-related death. In most cases, prostate cancer can be successfully treated but there is a group of patients who suffer an aggressive course and often fatal outcome.

23 Dec 2021

Discovery may lead to a better understanding of prion and other neurodegenerative diseases

Prion diseases, such as Creutzfeldt-Jakob Disease (CJD), are fast-moving, fatal dementia syndromes associated with the formation of aggregates of the prion protein, PrP.

23 Dec 2021

European Union-funded project lifts digital data storage to a new level

One of the technologies that researchers are examining to offer effective and inexpensive alternatives for data storage in the future is DNA digital data storage.

23 Dec 2021

Molecular & Structural Biology

Columbia researchers develop new blood test to measure the pace of biological aging

Changes in the activity of gene networks may explain arteriosclerosis risk

First molecular images of enzyme may help solve the mystery cause of hereditary neurodegenerative diseases

Experts develop AI-based binding site detection in nucleic acid macromolecules

Researchers determine how key protein drives the defense system to fight viruses

Increasing the expression of a gene slows Alzheimer’s progression in mice

Scientists develop DNA-based fluorescent nanoantenna to evaluate protein activity

CSHL researchers spotlight the role of a previously little-known protein in leukemia

Scientists discover new Senp5S protein with crucial role in brain development

Study may pave the way for designing next generation of artificial chromosomes for data storage

Researchers reveal molecular and cellular mechanisms that lead to tertiary lymphoid structures formation

Experts determine the assembly of proteins with specialized protein needles

Sampling zoo air could help collect enough DNA to identify the animals nearby

A highly effective protection against oxidative stress developed by present-day humans

Scientists discover how sponginess of stem cell nuclei controls cell differentiation

Blocking function of blood-clotting protein prevents bone loss from gum disease in mice

Unraveling how DNAzymes work in real time

Study identifies two proteins as novel markers of aggressive prostate cancer

Discovery may lead to a better understanding of prion and other neurodegenerative diseases

European Union-funded project lifts digital data storage to a new level

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

Commercializing Innovation in a Life Sciences Ecosystem

Latest in Genomics