Molecular & Structural Biology

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Breakthrough "Gene Silencing" Technology Could Revolutionize the Development of DNAzymes

Researchers from the University of California, Irvine have developed a DNA enzyme – or DNAzyme – that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact.

9 May 2023

Understanding How Interleukin-6 Contributes to Suppress Allergic Asthma and Atopy

The immune system has a biological telecommunications system -; small proteins known as interleukins that send signals among the leukocyte white blood cells to control their defense against infections or nascent cancer.

8 May 2023

Understanding How Supernumerary Chromosomes Arise

The majority of chromosomes have existed for millions of years.

5 May 2023

Multi-Angled Approach of Identifying Dual-Purpose Therapeutic Targets Implicated in Aging, Glioblastoma

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform."

3 May 2023

Study Reveals That Transcriptional Buffering Occurs in Rett Syndrome Nerve Cells

Every cell in our body is able to turn genes (DNA) on or off, producing RNA, but when genes are 'turned on' to the wrong level it can result in a variety of health conditions.

3 May 2023

Genes Responsible for Aging Identified in Nematodes

The USask research team uncovered a pair of genes involved in removing cells of toxins that build in the body and cause aging while working with small nematode worms called C. elegans. The researchers discovered that inactivating genes named CCF-1 and PAL-1 caused nematodes to die 50% faster than usual.

3 May 2023

New Extraction Protocol Offers a More Comprehensive Picture of Cellular Activity

Researchers at the Van Andel Institute have created a new extraction protocol for RNA-seq and metabolomic analysis that provides a more comprehensive picture of cellular activity than either technique alone.

3 May 2023

Argonne's Advanced Photon Source Helps Identify New Antibodies Against Coronaviruses

Results could speed development of new antivirals or vaccines that could counter many different coronavirus variants.

2 May 2023

New Bio-Inspired Molecules can Enhance Bone Regeneration in Mice

People's ability to regenerate bones declines with age and is further decreased by diseases such as osteoporosis.

2 May 2023

Understanding the Process of Gene Regulation Using Cryogenic Electron Microscopy

LMU researchers show detailed displacement process of TBP transcription factor from DNA by Mot1 enzyme.

2 May 2023

How Exploratory Actions Enable Animals to Efficiently Learn Their Spatial Environment

Neuroscientists have uncovered how exploratory actions enable animals to learn their spatial environment more efficiently.

2 May 2023

Development of Biocomputing’s Third Approach: Trumpet

Biological computing or biocomputing can revolutionize computers and medicine from early diagnosis and internal cure of diseases to futuristic applications like expanding human memory.

2 May 2023

Previously Unknown Regulatory Mechanism for Circadian and Temperature Signaling Pathways Revealed

Ever wondered why people become tired when the sun goes down? What causes some flower petals to open during the day and close at night? Or how monarch butterflies ascertain when to migrate south?

2 May 2023

Markers Indicating Early Signs of Schizophrenia Identified

For the first time, a global study group headed by investigators at Virginia Commonwealth University has found markers that might point out early if a person is susceptible to schizophrenia in the early stage itself.

28 Apr 2023

Csx28 Membrane Protein Enhances CRISPR's Anti-Viral Defense

CRISPR achieved scientific popularity for its capacity to quickly and precisely edit genes. At the core, however, CRISPR systems are immune systems that aid bacteria to safeguard themselves from viruses through targeting and abolishing viral RNA and DNA.

28 Apr 2023

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

28 Apr 2023

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A).

28 Apr 2023

Neuronal Activity Necessary and Sufficient to Drive Astrocyte Development

Researchers at Baylor College of Medicine have unraveled the processes that give astrocytes, the most abundant glial cell in the brain, their special bushy shape, which is fundamental for brain function.

27 Apr 2023

Modulation of ERK Signaling Could be Used to Stimulate Regeneration

Why do some animals regenerate lost tissues after injury while others don't? Researchers from the lab of Kerstin Bartscherer (Osnabrück University and formerly Hubrecht Institute) and Ashley Seifert (University of Kentucky) studied spiny mice, which have a remarkable regenerative capacity, to answer this question.

26 Apr 2023

Membrane-Remodeling Proteins in Cyanobacteria are Similar to Protein Found in Higher Organisms

The cells of living organisms are equipped with proteins that are involved in the shaping and remodeling of cellular membranes, thereby performing important tasks.

26 Apr 2023

Molecular & Structural Biology

Breakthrough "Gene Silencing" Technology Could Revolutionize the Development of DNAzymes

Understanding How Interleukin-6 Contributes to Suppress Allergic Asthma and Atopy

Understanding How Supernumerary Chromosomes Arise

Multi-Angled Approach of Identifying Dual-Purpose Therapeutic Targets Implicated in Aging, Glioblastoma

Study Reveals That Transcriptional Buffering Occurs in Rett Syndrome Nerve Cells

Genes Responsible for Aging Identified in Nematodes

New Extraction Protocol Offers a More Comprehensive Picture of Cellular Activity

Argonne's Advanced Photon Source Helps Identify New Antibodies Against Coronaviruses

New Bio-Inspired Molecules can Enhance Bone Regeneration in Mice

Understanding the Process of Gene Regulation Using Cryogenic Electron Microscopy

How Exploratory Actions Enable Animals to Efficiently Learn Their Spatial Environment

Development of Biocomputing’s Third Approach: Trumpet

Previously Unknown Regulatory Mechanism for Circadian and Temperature Signaling Pathways Revealed

Markers Indicating Early Signs of Schizophrenia Identified

Csx28 Membrane Protein Enhances CRISPR's Anti-Viral Defense

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

Neuronal Activity Necessary and Sufficient to Drive Astrocyte Development

Modulation of ERK Signaling Could be Used to Stimulate Regeneration

Membrane-Remodeling Proteins in Cyanobacteria are Similar to Protein Found in Higher Organisms

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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