Molecular & Structural Biology

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Previously Unknown Protein Reveals RNA Repair Mechanism in Humans

Ribonucleic acids (RNAs) are single-stranded molecules that are found in all living organisms’ cells. As “transcripts” of human genes, mRNAs, for instance, play a role in the translation of genetic information by bearing the instructions for the production of a protein in their own sequence.

26 Apr 2023

Interpretable Machine Learning Framework Helps Optimize Chromosome Design and Synthesis

Artificially synthesizing genomes has numerous applications, including medical research and industrial strains. Scientists are continuously progressing in the depth and breadth of genome design and synthesis, from Craig Venter’s team’s synthesis of the artificial life JCVI-syn1.0 in 2010 to the rewriting and synthesis of the prokaryotic E. coli genome, and the Sc2.0 project’s artificial synthesis of the yeast genome.

26 Apr 2023

Generating the Landscape of m6A in a Mouse Embryo

RNA, particularly mRNA, has recently received some attention as the major component of the COVID-19 vaccines.

26 Apr 2023

Antibacterial Biologic Agent Effective Against Staphylococcus Aureus Infections in Early Tests

Researchers at NYU Grossman School of Medicine and Janssen Biotech, Inc. have shown in early tests that a bioengineered drug candidate can counter infection with Staphylococcus aureus – a bacterial species widely resistant to antibiotics and a major cause of death in hospitalized patients.

25 Apr 2023

Universal Mechanism by Which Cells Determine DNA Shape Uncovered

We finally know why our DNA has an X shape. This finding by researchers at the Netherlands Cancer Institute may have much broader implications for how our cells behave.

21 Apr 2023

Food-Poisoning Bacteria Create Syringe-Like Structures to Inject Toxins Into Intestinal Cells

Researchers at UT Southwestern Medical Center have discovered how a bacterium that infects people after they eat raw or undercooked shellfish creates syringe-like structures to inject its toxins into intestinal cells.

21 Apr 2023

Spatial Organization of Chromosomes and the Role of DNA Tension

Two protein complexes are primarily responsible for chromosomal spatial organization in human cell nuclei. DNA tension has an unanticipated function in this. Together with Austrian colleagues, nanoscientist Cees Dekker and his PhD candidate Roman Barth of TU Delft’s Kavli Institute of Nanoscience published their detailed visualization in Nature on April 19th, 2023.

21 Apr 2023

Unveiling the Molecular Structure of the Ssp Toxin from Serratia marcescens

A multinational research group has uncovered how the bacterial toxin Ssp may penetrate and kill a wide variety of living cells, including human cells.

21 Apr 2023

A Previously Unknown Mechanism for DNA Folding Revealed

A hitherto unknown mechanism for DNA folding is described in a study in Nature published by researchers from Karolinska Institutet and the Max Planck Institute for Biophysics.

20 Apr 2023

Mind-Body Connection is More Than Just an Abstraction

Calm body, calm mind, say the practitioners of mindfulness. A new study by researchers at Washington University School of Medicine in St. Louis indicates that the idea that the body and mind are inextricably intertwined is more than just an abstraction.

20 Apr 2023

Researchers Identify Novel Role of a Protein in the Development of Alcohol-Associated Liver Disease

Alcohol-associated liver disease (ALD), a complex disorder that occurs in some patients who have engaged in excessive alcohol use, is one of the leading causes of chronic liver disease among veterans and liver transplant patients in the United States.

19 Apr 2023

The Function of ANKLE1 in the Prevention of DNA Damage and Autoimmunity

The University of Hong Kong (HKU) School of Biological Sciences research team led by Dr. Gary Ying Wai Chan has uncovered the function of a unique enzyme called ANKLE1.

19 Apr 2023

UH Researcher Designs New Model Expressing the Most Common Disease Mutation in USH2A

Usher syndrome, a rare inherited genetic disease, is a leading cause of combined deafness and blindness with type 2A (USH2A) being the most common form.

18 Apr 2023

The Implications of Biological Clock on Lung Health

The body’s biological clock is interfered with by abnormal sleep habits, such as those of night shift workers, which have been connected to lung health problems.

18 Apr 2023

Two Molecular Mechanisms Combine to Make the Bacterium Extra Resistant

When the intestinal flora is killed by antibiotics, a species of ordinary gut bacteria that humans carry flourishes. Because the bacteria are naturally immune to many drugs, it poses complications, especially in healthcare settings.

18 Apr 2023

A Protein Domain Could Lead to New Treatments for COVID-19

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

18 Apr 2023

New Peptide Blocks a Hyperactive Brain Enzyme Involved in Neurodegeneration

MIT neuroscientists have found a way to reverse neurodegeneration and other symptoms of Alzheimer's disease by interfering with an enzyme that is typically overactive in the brains of Alzheimer's patients.

17 Apr 2023

Chemists Propose New Hypothesis for How the First Sugars Arose on the Earth

Two prominent origin-of-life chemists have published a new hypothesis for how the first sugars-;which were necessary for life to evolve-;arose on the early Earth.

17 Apr 2023

Study Presents Crucial Themes in the Biology of Pancreatic Cancer

Scientists from the University of California, Irvine, the University of Michigan and the University of Texas MD Anderson Cancer Center have made a significant contribution to the field of pancreatic cancer research.

17 Apr 2023

Next-Generation Sequencing Provides New Insights into Mutations of Mitochondrial DNA

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies and genetic diagnosis of embryos prior to their implantation.

17 Apr 2023

Molecular & Structural Biology

Previously Unknown Protein Reveals RNA Repair Mechanism in Humans

Interpretable Machine Learning Framework Helps Optimize Chromosome Design and Synthesis

Generating the Landscape of m6A in a Mouse Embryo

Antibacterial Biologic Agent Effective Against Staphylococcus Aureus Infections in Early Tests

Universal Mechanism by Which Cells Determine DNA Shape Uncovered

Food-Poisoning Bacteria Create Syringe-Like Structures to Inject Toxins Into Intestinal Cells

Spatial Organization of Chromosomes and the Role of DNA Tension

Unveiling the Molecular Structure of the Ssp Toxin from Serratia marcescens

A Previously Unknown Mechanism for DNA Folding Revealed

Mind-Body Connection is More Than Just an Abstraction

Researchers Identify Novel Role of a Protein in the Development of Alcohol-Associated Liver Disease

The Function of ANKLE1 in the Prevention of DNA Damage and Autoimmunity

UH Researcher Designs New Model Expressing the Most Common Disease Mutation in USH2A

The Implications of Biological Clock on Lung Health

Two Molecular Mechanisms Combine to Make the Bacterium Extra Resistant

A Protein Domain Could Lead to New Treatments for COVID-19

New Peptide Blocks a Hyperactive Brain Enzyme Involved in Neurodegeneration

Chemists Propose New Hypothesis for How the First Sugars Arose on the Earth

Study Presents Crucial Themes in the Biology of Pancreatic Cancer

Next-Generation Sequencing Provides New Insights into Mutations of Mitochondrial DNA

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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