Molecular & Structural Biology

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Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

Astrocytes modulate balance in neural networks, control decision making

Decision-making during goal-directed behaviors is deliberative process involving different brain areas that considers pros and cons of each option.

8 Dec 2020

Researchers identify genes that determine the shelf life of flaxseed oil

Biologists have analyzed the genes that establish the composition of fatty acids in flaxseed oil and detected polymorphisms in six of those genes.

7 Dec 2020

Gene therapy and medication can provide certain beneficial effects of physical exercise

Jose Bianco Moreira from NTNU is now convinced that gene therapy can be used to achieve the positive health benefits of physical exercise.

7 Dec 2020

Study: Blood type is not associated with effects of plant-based diet on body weight

A study published in the Journal of the Academy of Nutrition and Dietetics by researchers with the Physicians Committee for Responsible Medicine--a nonprofit of 12,000 doctors--debunks the "blood type diet" by finding that blood type was not associated with the effects of a plant-based diet on body weight, body fat, plasma lipid concentrations, or glycemic control.

7 Dec 2020

Biochemist discovers hidden cellular machinery essential for higher-order life

In his first year of graduate school, Rice University biochemist Zachary Wright discovered something hidden inside a common piece of cellular machinery that's essential for all higher order life from yeast to humans.

7 Dec 2020

Scientists reveal health benefits of clonal hematopoiesis in allogeneic transplants

Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don't have cancer. People with CH, while asymptomatic, have an elevated risk of developing blood cancers and other negative health outcomes, including heart attacks and strokes.

7 Dec 2020

Study shows fluorescent protein molecules act as tiny antennas with optical properties

Scientists have revealed that fluorescent protein molecules serve as antennas with optical characteristics according to their spatial orientation.

4 Dec 2020

Study sheds new light on potential risk factors for preterm birth

A recent study has detected new genetic markers linked to the duration of gestation. These findings shed new light on the possible risk factors for preterm birth.

4 Dec 2020

Study examines effect of wind turbine noise on sleep, wellbeing of nearby residents

As wind power generation becomes more important, experts in Australia are examining whether wind 'farm' turbine background noise in the environmental can affect sleep and wellbeing of nearby residents.

4 Dec 2020

Study explains new associations between Neanderthal DNA and autoimmune diseases

A researcher at the University of Tartu described new associations between Neanderthal DNA and autoimmune diseases, prostate cancer and type 2 diabetes.

4 Dec 2020

Scientists propose a simple model for gene regulation in higher organisms

Although the DNA and its double-helix are some of the most familiar molecules of our time, our knowledge of how cells control what genes they want to express still is rather limited. In order to create, for example, an enzyme, the information that's inscribed in our DNA about this enzyme needs to be transcribed and translated.

4 Dec 2020

Researchers determine 3D structures of RNA hybridization with artificial nucleic acids

As medical research progresses, traditional treatment protocols are being rapidly exhausted. New approaches to treat diseases that do not respond to conventional drugs are the need of the hour.

4 Dec 2020

Research reveals fundamental insights into the causes of severe birth defects

Research by Kai Jiao, M.D., Ph.D., and colleagues at the University of Alabama at Birmingham and in Germany has yielded fundamental insights into the causes of severe birth defects known as CHARGE syndrome cases. These congenital birth defects include severe and life-threatening heart malformations.

3 Dec 2020

Drug meant for bacterial infections can combat weight gain

A drug originally developed to treat bacterial infections has proved capable of boosting the metabolism and attenuating the weight gain induced by a fatty diet in tests with mice. The study was conducted at the University of Campinas (UNICAMP) with FAPESP's support, and the findings have just been published in the journal Science Advances.

3 Dec 2020

Molecular & Structural Biology

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Astrocytes modulate balance in neural networks, control decision making

Researchers identify genes that determine the shelf life of flaxseed oil

Gene therapy and medication can provide certain beneficial effects of physical exercise

Study: Blood type is not associated with effects of plant-based diet on body weight

Biochemist discovers hidden cellular machinery essential for higher-order life

Scientists reveal health benefits of clonal hematopoiesis in allogeneic transplants

Study shows fluorescent protein molecules act as tiny antennas with optical properties

Study sheds new light on potential risk factors for preterm birth

Study examines effect of wind turbine noise on sleep, wellbeing of nearby residents

Study explains new associations between Neanderthal DNA and autoimmune diseases

Scientists propose a simple model for gene regulation in higher organisms

Researchers determine 3D structures of RNA hybridization with artificial nucleic acids

Research reveals fundamental insights into the causes of severe birth defects

Drug meant for bacterial infections can combat weight gain

Researchers identify key target that allows cancer cells to spread more efficiently

Study confirms that telomere shortening helps prevent cancer in humans

Research may lead to new strategies for calcium malabsorption

Researchers develop new tool to study genes associated with autism spectrum disorder

Researchers identify molecular mechanisms that reverse aging

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