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Engineering Yeast Promoters for Biologic Manufacturing

When introducing genes into yeast to make it produce drugs and other useful substances, it is also necessary to reliably switch the production on or off. A Kobe University team found three gene regulation design principles that provide a flexible guideline for the effective control of microbiological production.

19 Dec 2024

A Novel Method for Synthesizing Piperidines for Modern Medicine

A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines biocatalytic carbon-hydrogen oxidation and radical cross-coupling, offering a streamlined and cost-effective approach to create complex, three-dimensional molecules.

19 Dec 2024

Chaperone Proteins Unveil Their Role in Neurotransmission

A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are vital in ensuring that neurons can transmit signals to one another. When this neurotransmission breaks down, devastating diseases such as Alzheimer's and Parkinson's along with many others, can occur.

19 Dec 2024

Neural Stem Cells Found to Rejuvenate the Aging Brain

Much like plants in a thriving forest, certain cells in the brain create a nurturing environment, enhancing the health and resilience of their neighbors, while others promote stress and damage, akin to a noxious weed in an ecosystem.

19 Dec 2024

Subsurface Microbial Life Reveals Surprising Diversity in Extreme Environments

Which microbes thrive below us in darkness – in gold mines, in aquifers, in deep boreholes in the seafloor – and how do they compare to the microbiomes that envelop the Earth's surfaces, on land and sea?

19 Dec 2024

Silver-Containing Showerheads Fail to Reduce Pathogens in Real-World Conditions

To guard against harmful waterborne pathogens, many consumers, including managers of health-care facilities, install antimicrobial silver-containing showerheads.

19 Dec 2024

Unveiling Human Stem Cell Model with Functional Notochord

For the first time, the notochord a tissue in the developing embryo that serves as a navigation system, telling cells where to build the spine and nervous system (the trunk) has been included in human stem cell models created by researchers at the Francis Crick Institute.

19 Dec 2024

Marine Microalgae Use Light Sensors to Navigate the Ocean

Ocean-dwelling phytoplankton is known to be essential to marine ecosystems and climate regulation.

19 Dec 2024

Scientists Mimic Fungal Process to Create Novel Medicines

Since the unintentional 1928 discovery of penicillin by Alexander Fleming, fungi have been a treasure trove of medicinal compounds for almost a century.

19 Dec 2024

Molding the Mind: Researchers use Neurofeedback To Reshape Brain Perception

A study reveals how real-time fMRI neurofeedback can reshape neural activity, enhancing perceptual learning and creating new visual categories in the brain.

19 Dec 2024

Researchers Uncover Ketamine’s Effect on Astrocytes in Zebrafish

The decades-old anesthetic ketamine could be a game changer for treating severe depression, but there are still many questions about how the drug works, including exactly how it affects the brain's cells and circuits.

18 Dec 2024

Yeast Proteins Found to Offer Powerful Emulsifying Action

Mention emulsifiers and many people might be unaware what they are used for, but they are present in many daily products, from food to cosmetics.

18 Dec 2024

New Insights into Photosystem II Megacomplex Assembly in Plants

In higher plants and green algae, Photosystem II (PSII) usually combines with Light Harvesting Complex II (LHCII) to form the PSII-LHCII supercomplex.

18 Dec 2024

New Virus Found to Alter Cell Machinery in Eukaryotic Cells

Julie Thomy, lead author of the study and postdoctoral researcher in the Daniel K. Inouye Center for Microbial Oceanography: Research and Education (C-MORE) and Department of Oceanography in the UH Mānoa School of Ocean and Earth Science and Technology (SOEST)

18 Dec 2024

Space Experiment Reveals Surprising Brain Cell Behavior

Microgravity exposure accelerates brain cell development in organoids, revealing potential implications for neurodegenerative disease research and space health.

18 Dec 2024

New Strategy to Combat Antibiotic-Resistant Bacteria

The discovery of a vulnerability in antibiotic resistance mechanisms may lead to improved strategies for combating superbugs and enhancing current therapies.

18 Dec 2024

Scientists Discover Key to Overcoming Cancer's Evasion Tactics

A cunning culprit that aids cancer cells in avoiding CAR T cell therapy has been identified by researchers at City of Hope®, one of the biggest and most cutting-edge cancer research and treatment organizations in the United States, with a comprehensive cancer center in Los Angeles that is ranked among the top five cancer centers in the country by US News & World Report.

18 Dec 2024

Terumo Blood and Cell Technologies Presents Data on Automated Red Blood Cell Exchange to Treat Sickle Cell Disease at the American Society of Hematology

The abstracts highlight the potential to improve SCD treatment using aRBCX. The first poster presents data from U.S. insurance claims, examined in a study performed with researchers at University of Pittsburgh.

18 Dec 2024

A revolutionary antibody approach to fight cancer by restoring cellular fitness

Ovarian cancer cells exploit cell competition by altering Flower protein isoforms in stromal cells, promoting tumor survival and potential therapeutic targets.

18 Dec 2024

Exploring the Potential of Probiotics to Restore Gut Microbiota After Antibiotic Disruption

Antibiotics are important clinical tools for treating bacterial infections, yet we recognize that an important side effect of antibiotic use is disruption of the microbial community living in the human gut.

17 Dec 2024