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A Novel Biosensor for Calcium Detection in Fruit Flies, Zebrafish, and Mice

In 2021, the Janelia group leaders reported that they had developed a way to combine Schreiter's engineered protein biosensors and Lavis's bright, fluorescent Janelia Fluor dyes.

23 Sep 2024

AI-Driven Insights into Lasso Peptide Biosynthesis

Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions. In a new study, published in Nature Chemical Biology, researchers have constructed and tested models for how these peptides are made and demonstrated how this information might be used to advance lasso peptide-based drugs into the clinic.

23 Sep 2024

A New Understanding of the Effects of Fever on Immune Cells

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -; in a particular subset of T cells -; cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center researchers have discovered.

23 Sep 2024

Unraveling the Genetic Mechanisms Underlying Fruit Size and Sugar Content in Wax Apple

A recent study has successfully decoded the autotetraploid genome of the wax apple, uncovering its genetic evolution and key factors driving fruit diversity. The research highlights the fruit's rich antioxidant profile, with promising implications for human health and breeding strategies aimed at enhancing nutritional value.

23 Sep 2024

DNA Duplication Determines Horse Coat Color and Melanoma Risk

Scientists from the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) and Uppsala University in Sweden now understand why some gray horses turn completely white as they age, while others remain an eye-catching "dappled" gray color.

23 Sep 2024

Harnessing the Power of Beneficial Bacteria to Fight Enterobacteriaceae

Antibiotic-resistant bacterial infections often occur in patients with chronic inflammatory intestinal conditions, such as inflammatory bowel disease, and in patients who have taken antibiotics for a long time. Gram-negative bacteria such as Enterobacteriaceae are a common cause of these infections and have few treatment options. Fecal microbiota transplants have shown promise to curb some of these infections, but their composition varies between batches and they aren't always successful.

23 Sep 2024

Scientists Develop Lab-Grown Muscle Stem Cells for Advanced Regenerative Therapies

Recent findings reveal that induced satellite cells can effectively regenerate muscle tissue, outperforming traditional myoblasts in engraftment and function.

23 Sep 2024

Novel Tool Helps Identify Snake Venom Genes Across Species

Only about ten percent of the world's roughly 4,000 snake species have venom strong enough to seriously hurt a human, but that's enough for snake bites to be an important public health concern.

20 Sep 2024

New Method Analyzes Tooth Enamel Proteins to Gain Insights into Human Health History

A new way of looking at tooth enamel could give scientists a path to deeper understanding of the health of human populations, from the ancient to the modern.

20 Sep 2024

Comprehensive multi-omics approach reveals detailed insights into diabetes mechanisms

In a recent study published in Nature Communications, researchers utilized a comprehensive multi-omics approach, integrating genomic, proteomic, and metabolomic data from a diverse cohort, to uncover detailed molecular interactions and identify distinct diabetes subgroups.

20 Sep 2024

Sodium Transport Found to Play a Surprising Role in Mitochondrial Energy Production

The GENOXPHOS (Functional Genetics of the Oxidative Phosphorylation System) group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has discovered a crucial role of sodium in the generation of cellular energy.

20 Sep 2024

Gene-Based Tool Predicts Cherry Blossom Blooming Times

Japan is well-known for its sakura, or cherry blossoms, which bloom in the southern Kyushu region and ascend to the far north of Hokkaido in the spring.

20 Sep 2024

Study Finds How Plants Limit Viral Spread to Progeny with RNA Interference

Scientists have learned how plants keep viruses from being passed to their offspring, a finding that could ensure healthier crops.

20 Sep 2024

Antifreeze Fish Shed Light on How New Genes Evolve

From where do novel genes originate? In a recent study, a group of University of Arkansas researchers studying biological sciences set out to address that topic.

20 Sep 2024

Revolutionizing Cucumber Genetics with Magnetofection

Researchers have achieved a groundbreaking advancement in plant biotechnology by using a magnetofected pollen gene delivery system to genetically transform cucumbers.

19 Sep 2024

Genetic Blueprint Reveals Germination Barriers in the Endangered Jacktree

A pivotal study unveils the genetic blueprint of the endangered Jacktree, shedding light on the molecular factors hindering its germination.

19 Sep 2024

The Role of Ancient Viral Sequences in Gene Regulation

For any organism to survive and thrive, its cells must tightly control which genes are activated when, and where.

19 Sep 2024

Research Shows a Causal Role of Histone Modifications in Gene Regulation

For any organism to survive and thrive, its cells must strictly control which genes are active when and where.

19 Sep 2024

Epigenetic Switch Found to Activate Genes in Embryos

Researchers led by the Institute of Molecular Biology have found that 5-formylcytosine (5fC), a DNA alteration, acts as an activating epigenetic switch to activate genes during the early stages of embryonic development.

19 Sep 2024

New study highlights the medicinal potential of plants consumed by gorillas

In a recent study, researchers examined the antibacterial and antioxidant properties of plants used by western lowland gorillas for self-medication, highlighting the potential of these bioactive compounds for therapeutic applications in human medicine.

19 Sep 2024