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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Gamma-Actin's Influence on Cell Rigidity and Junctional Proteins

Epithelial cells defend human skin and mucous membranes. Specialized structures known as “junctions” enable this “barrier” tissue to carry out its role. They control interactions between cells and maintain cell cohesion.

21 Mar 2025

Researchers Identify Promising Drug Candidates for Previously “undruggable” Cancer Target

For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein target, permanently blocking it.

21 Mar 2025

New Database Provides Insights into snoRNA Expression in Zebrafish

Small nucleolar RNAs (snoRNAs) are non-coding RNA molecules whose role in gene regulation and their association with certain diseases, such as inflammatory bowel disease (IBD) or colorectal cancer, has only recently become known.

20 Mar 2025

RNA-Based Active Agents Successfully Shield Plants from Cucumber Mosaic Virus

New RNA-based active agents reliably protect plants against the Cucumber mosaic virus (CMV), the most common virus in agriculture and horticulture. They were developed by researchers at the Martin Luther University Halle-Wittenberg (MLU).

20 Mar 2025

Research Unveils Mechanism Behind Evolution of Organelles from Bacteria

Organelles in cells were originally often independent cells, which were incorporated by host cells and lost their independence in the course of evolution.

20 Mar 2025

Pregnancy Triggers Small Intestine Growth in Mice

Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare for a second.

20 Mar 2025

New Insights into How B Cells Strategically Clone High-Affinity Antibodies

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies.

20 Mar 2025

Advanced Imaging Deciphers B Cell Dynamics in Lymph Nodes

Germinal centers are machines of rapid evolution. Germinal centers are tiny clusters in the lymph nodes that refine antibodies through proliferation and mutation to create high-affinity B cells that are suited to control various infections.

20 Mar 2025

Sapio Sciences Makes AI-Native Drug Discovery Seamless with NVIDIA BioNeMo

Sapio Sciences, the science-aware™ lab informatics platform, today announced the integration of the NVIDIA BioNeMo platform into the Sapio Lab Informatics Platform.

From Sapio Sciences 19 Mar 2025

Mechanical Forces Determine the Winners in Cell Competition

Trial of strength at the cellular level: cells are in constant competition with each other and so eliminate diseased or unwanted cells.

18 Mar 2025

New Insights into RNA Editing Mechanisms for Autoimmune and Cancer Therapies

A research team led by Yang Gao from Rice University has made significant strides in understanding the molecular mechanisms of ADAR1, a protein that modulates ribonucleic acid (RNA) induced immune responses.

18 Mar 2025

Understanding How Tumor-Derived Extracellular Vesicles Enter Target Cells

Most cells in the body send out little messengers called extracellular vesicles that carry proteins, lipids, and other bioactive molecules to other cells, playing an important role in intercellular communication.

17 Mar 2025

Breakthrough Microscopy Sheds Light on the Dynamics of Biomolecular Condensates

Biomolecular condensates are shifting blobs in our cells that organize cellular matter. They are distinct molecular communities made of DNA, RNA and proteins that "condense" molecules to key locations, yet they frequently defy description.

17 Mar 2025

New Discovery in RNA Splicing Could Transform Treatment of Aggressive Cancers

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different versions of a film.

17 Mar 2025

Ultrasensitive Pathogen Detection Without Nucleic Acid Amplification

Rashid Bashir, a Bioengineering Professor and Dean of the Grainger College of Engineering oversaw a group of researchers in a project that produced new technology that provides quick, extremely sensitive detection of bacteria and other pathogens at low concentrations that are resistant to multiple drugs.

17 Mar 2025

Stanford Researchers Find a Molecule That Rivals Ozempic in Weight Loss

BRP emerges as a promising peptide for weight loss, activating appetite control pathways without triggering nausea, paving the way for safer obesity therapies.

17 Mar 2025

Mitochondria Found to Control DNA Repair Protein and Delay Inflammaging

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.

14 Mar 2025

Study Reveals How Syngap1 Gene Affects Touch-Based Perception in Mice

You may scarcely notice it, but much of what you do every day requires your brain to engage in perceptual learning.

14 Mar 2025

Bispecific antibodies for SARS-CoV-2 variant neutralization

Bispecific antibodies targeting multiple SARS-CoV-2 sites offer enhanced neutralization against emerging variants, advancing COVID-19 treatment strategies.

14 Mar 2025

SRS Microscopy Unlocks New Insights into Cellular Metabolism and Disease

Cellular metabolism plays a critical role in various physiological and pathological processes. High resolution imaging of intracellular metabolic activities is crucial for understanding many biological pathways, and for facilitating disease prognosis and treatment assessment.

14 Mar 2025