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Researchers identify new therapeutic targets for flaviviruses

In a recent study, Australian scientists used an original approach to resolve the 3D structure of flaviviruses with an unprecedented level of detail, identifying small molecules known as 'pocket factors' as new therapeutic targets.

2 Jun 2021

24 Hours of Life Science Online Conference

On June 2, 2021, JEOL will focus on advances in life science research using electron microscopy in its “24 Hours of Life Science” conference.

From JEOL USA, Inc. 21 May 2021

Natural molecule can effectively block the binding of human antibodies to SARS-CoV-2

Researchers have found that a natural molecule can effectively block the binding of a subset of human antibodies to SARS-CoV-2. The discovery may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus.

23 Apr 2021

Study reveals how some antibodies can effectively disable ebolaviruses

Some survivors of ebolavirus outbreaks make antibodies that can broadly neutralize these viruses--and now, scientists at Scripps Research have illuminated how these antibodies can disable the viruses so effectively. The insights may be helpful for developing effective therapies.

16 Apr 2021

Novel method to activate and visualize protein channels that keep bacteria alive

Almost all bacteria rely on the same emergency valves--protein channels that pop open under pressure, releasing a deluge of cell contents.

15 Apr 2021

Study discovers how some proteins ensure repair of errors introduced during DNA replication

Researchers have discovered how specific proteins ensure the rectification of errors introduced into the DNA when it replicates.

7 Apr 2021

Supercomputer simulations help uncover the mechanism for HIV replication

Viruses lurk in the grey area between the living and the nonliving, according to scientists. Like living things, they replicate but they don't do it on their own. The HIV-1 virus, like all viruses, needs to hijack a host cell through infection in order to make copies of itself.

1 Apr 2021

Study reveals how lipids and water molecules control 5-hydroxytryptamine receptors

Serotonin, or 5-hydroxytryptamine (5-HT), is a kind of neurotransmitter. 5-HT can regulate multifaceted physiological functions such as mood, cognition, learning, memory, and emotions through 5-HT receptors.

26 Mar 2021

Cryogenic electron microscopy helps visualize 3D structure of complex responsible for gene regulation

A research team has looked inside a human cell to visualize a multi-subunit machine that is responsible for controlling the expression of genes.

15 Mar 2021

Fluorescent chemical dye helps track specific motor protein within cells

A cell can stay alive only when it supplies all the required energy elements to its various organelles and these elements are formed in the Golgi apparatus.

8 Mar 2021

New models can optimize wastewater disinfection process, prevent spread of antibiotic resistance

For almost a century, advances in human healthcare have largely relied on the efficiency through which bacterial diseases can be treated.

3 Mar 2021

Detective work inside plant cells finds a key piece of the C4 photosynthesis puzzle

An impressive body of evidence published this week reveals the answer to a mystery that has puzzled plant scientists for more than 30 years.

3 Mar 2021

Scientists gain new insights into ribosome formation to identify potential drug targets

Ribosome formation is viewed as a promising potential target for new antibacterial agents. Researchers from Charité - Universitätsmedizin Berlin have gained new insights into this multifaceted process.

2 Mar 2021

DNA origami helps track gene-editing processes

The genetic scissors, known as CRISPR/Cas9, the finding that received a Nobel Prize in Chemistry, occasionally cut in places that they are not intended to target.

24 Feb 2021

Study reveals specialized mechanism for translation of mitochondrial genome into proteins

An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome.

23 Feb 2021

Using soil bacteria for antibiotic production

In this interview, AZoLifeSciences speaks to Dr. Christophe Corre about his latest research that investigated soil bacteria and how it could be used to produce antibiotics.

From The University of Warwick 19 Feb 2021

Cryogenic electron microscopy reveals shape of glutamate transporters involved in neurological diseases

An international research team has uncovered the shape of the glutamate transporter and helps explain how the human brain cells interact with each other.

18 Feb 2021

New technique reveals natural structure of large enzyme complex

A new technique has revealed the natural structure of specifically massive and complex enzymes.

11 Feb 2021

Scientists determine biological mechanism that may lead to more efficient antibiotics

Hormone-mimicking molecules that trigger the production of antibiotics in soil bacteria could present new opportunities for drugs that are right under our feet.

From The University of Warwick 5 Feb 2021

Study describes dynamic link between protein folding and misfolding

Correct, or native, protein folding is essential for correct protein function. Protein misfolding can lead to the formation of amyloid fibrils, and amyloidosis, which is implicated in various human neurodegenerative diseases, including Parkinson's, Alzheimer's, and Huntington's diseases.

From Osaka University 2 Feb 2021